Heart-Type Fatty Acid Binding Protein: A Better Cardiac Biomarker than CK-MB and Myoglobin in the Early Diagnosis of Acute Myocardial Infarction

Pyati, Dr Anand K

doi:10.7860/jcdr/2015/15132.6684

Cited by 29 publications

(31 citation statements)

References 18 publications

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“…Interesting results were obtained for the studied biochemical necrosis biomarkers regarding sensitivity, specificity, positive and negative predictive value and accuracy. H-FABP measured on admission showed as high as 94.7% sensitivity, 100% specificity, 100% positive predictive value, 93.4% negative predictive value and 97% accuracy 33 . H-FABP is a sensitive marker for the detection of cardiovascular damage, but is not 100% cardiac-specific, because of its presence in tissues outside the heart.…”

Section: Discussionmentioning

confidence: 99%

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2017

IJPSR

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Section: Discussionmentioning

confidence: 99%

“…MI is one of the most serious challenges of contemporary cardiology. Among biochemical markers, H-FABP has a high potential as a marker for the early diagnosis of acute MI 33 .…”

Section: Discussionmentioning

confidence: 99%

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2017

IJPSR

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“…H-FABP is a small, cytosolic protein in the myocardium and has recently attracted major interest as a novel biomarker for myocardial ischemia24. We included this biomarker in our study to validate the occurrence of transient ischemia.…”

Section: Resultsmentioning

confidence: 99%

Highly Sensitive Detection of Minimal Cardiac Ischemia using Positron Emission Tomography Imaging of Activated Platelets

Ziegler

Alt

Paterson

et al. 2016

Sci Rep

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A reliable method for the diagnosis of minimal cardiac ischemia would meet a strong demand for the sensitive diagnosis of coronary artery disease in cardiac stress testing and risk stratification in patients with chest pain but unremarkable ECGs and biomarkers. We hypothesized that platelets accumulate early on in ischemic myocardium and a newly developed technology of non-invasive molecular PET imaging of activated platelets can thus detect minimal degrees of myocardial ischemia. To induce different degrees of minimal cardiac ischemia, the left anterior descending artery (LAD) was ligated for 10, 20 or 60 min. Mice were injected with a newly generated scFvanti-GPIIb/IIIa-64CuMeCOSar radiotracer, composed of a single-chain antibody that only binds to activated integrin GPIIb/IIIa (αIIbβIII) and thus to activated platelets, and a sarcophagine cage MeCOSar complexing the long half-life PET tracer copper-64. A single PET/CT scan was performed. Evans Blue/TTC staining to detect necrosis as well as classical serological biomarkers like Troponin I and heart-type fatty acid-binding protein (H-FABP) were negative, whereas PET imaging of activated platelets was able to detect small degrees of ischemia. Taken together, molecular PET imaging of activated platelets represents a unique and highly sensitive method to detect minimal cardiac ischemia.

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“…The concentration of plasma lp-PLA2 was determined by immunoturbidimetric assay with a NORMAN-2 scattering analyzer (Norman Biology Technology Co., Ltd. Nanjing, China). 17,18) The Lp-PLA2 test box was also produced by this company. All procedures were performed according to the manufacturer's protocol.…”

Section: )mentioning

confidence: 99%

Plasma Lipoprotein-Associated Phospholipase A2 Level Is an Independent Predictor of High Thrombus Burden in Patients With Acute ST-segment Elevation Myocardial Infarction

Zhang

et al. 2016

Int. Heart J.

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SummaryLipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent risk factor for plaque rupture and atherothrombotic events. However, the associations between serum Lp-PLA2 level and thrombus burden in ST-segment elevation myocardial infarction (STEMI) patients remain unknown.We consecutively enrolled 351 STEMI patients who underwent primary percutaneous coronary intervention (pPCI). Patients were assigned to a high thrombus burden (HTB) group (n = 230) and a low thrombus burden (LTB) group (n = 121). Baseline data were recorded during hospital admission. Plasma Lp-PLA2 concentration, coronary angiography results, and in-hospital mortality were measured. Plasma Lp-PLA2 level had a high correlation with thrombus burden score (TBS) before pPCI and it was found to be a significant independent predictor of HTB in STEMI patients (P < 0.05). Moreover, TBS, corrected thrombolysis in myocardial infarction (TIMI) frame count (cTFC), and plasma Lp-PLA2 level after pPCI in patients with HTB were significantly higher than those in patients with LTB (P < 0.05). Meanwhile, TIMI flow grade (TFG) and TIMI myocardial perfusion grade (TMPG) of HTB patients were markedly lower than those of LTB patients (P < 0.05). Additionally, correlations of plasma Lp-PLA2 level before pPCI with TFG before pPCI and TBS, cTFC, and TMPG after pPCI were modest (P < 0.05). However, the associations of plasma Lp-PLA2 level after pPCI with TFG, TBS, cTFC and TMPG were low (P < 0.05).These results demonstrated that the plasma Lp-PLA2 level before pPCI is an independent predictor of HTB in STEMI patients, resulting in modestly predicting blood flow and myocardial perfusion of the culprit artery. (Int Heart J 2016; 57: 689-696) Key words: Acute myocardial infarction S T-segment elevation myocardial infarction (STEMI) is the most serious type of coronary heart disease and has a high mortality. Accumulated data have indicated that coronary thrombosis in an infarct related artery (IRA) plays a significant role in the development of STEMI. Furthermore, high thrombus burden (HTB) in an IRA can lead to various conditions such as stent thrombosis, distal embolism, slowand non-reflow, and long-term mortality.1-3) Therefore, it is very important to find a good predictive factor of HTB so at an early point in time we can give these patients with HTB some more intensive medical therapy such as enhanced antiplatelet and anticoagulation therapy, despite the recent pharmacological and invasive developments (ie, glycoprotein IIb/IIIa antagonists and thrombectomy) used in primary percutaneous coronary intervention (pPCI) therapy. 3,4)The pathophysiology of STEMI involves inflammatory reaction, endothelium dysfunction, plaque rupture, platelet aggregation, and coagulation system activation. Inflammation plays an important role in the pathogenesis of plaque instability, and results in plaque rupture or erosion.5) Pathological and immunohistochemical staining in the ruptured plaques of patients who have died of AMI have shown a preponderance of inflammatory cell...

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Heart-Type Fatty Acid Binding Protein: A Better Cardiac Biomarker than CK-MB and Myoglobin in the Early Diagnosis of Acute Myocardial Infarction

Cited by 29 publications

References 18 publications

Untitled

Untitled

Highly Sensitive Detection of Minimal Cardiac Ischemia using Positron Emission Tomography Imaging of Activated Platelets

Plasma Lipoprotein-Associated Phospholipase A2 Level Is an Independent Predictor of High Thrombus Burden in Patients With Acute ST-segment Elevation Myocardial Infarction

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