From July 1980 to December 1985, 124 patients underwent isolated aortic valve replacement with the Carpentier‐Edwards pericardial bioprosthesis. The mean age of the patients was 64.9 ± 13.1 years. All patients but one (0.7%) were followed for an average of 5.52 ± 0.21 years after the operation and follow‐up totaled to 677 patient‐years. There were six early deaths (30‐day mortality of 4.8%) and 25 late deaths (3.7% ± 0.7% patient‐year). After 9 years the actuarial survival rate was 64% ± 14%. Six patients died of valve‐related deaths (three anticoagulant‐related hemorrhage, one endocarditis, one thromboembolic complication, and one sudden death) for an actuarial rate of 95% ± 5% patients free of valve‐related death at 9 years. Valve‐related complications included five thromboembolic episodes (0.7% ± 0.3% patient‐year), eight anticoagulant‐related hemorrhagic complications (1.2% ± 0.4% patient‐year), and two reoperations (0.3% ± 0.2% patient‐year). After 9 years, freedom from thromboembolic events was 96% ± 4%, that from anticoagulant‐related hemorrhage was 93% ± 5%, and that from reoperation was 98% ± 2%. There was no structural deterioration of the valve. We conclude that the Carpentier‐Edwards pericardial prosthesis has a low incidence of valve‐related complication and mortality within the 9‐year time frame of this study.