Heartbeat: Improving acute myocardial infarction outcomes in women

Otto, Catherine M

doi:10.1136/heartjnl-2019-315000

Cited by 2 publications

(2 citation statements)

References 8 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results showed that there was no difference in the ventricular function between the study group and the model group before treatment, but the ventricular function in the study group was significantly higher than that in the model group and routine therapy group after treatment, suggesting that the combined treatment has better effect. Atorvastatin is a statin lipid-regulating drug (26), mainly acting on the liver, which can reduce the synthesis of cholesterol and has the effect of lowering blood lipid (27,28). Statins lipid-lowering drugs can improve the cardiac function of patients with acute myocardial infarction (29), and can be used for the treatment of the disorder of lipid metabolism in patients caused by acute myocardial infarction, which is beneficial to the treatment of acute myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

Atorvastatin combined with routine therapy on HIF-1, VEGF concentration and cardiac function in rats with acute myocardial infarction

Zhang

2020

Exp Ther Med

View full text Add to dashboard Cite

Effect of atorvastatin combined with routine therapy on the expression of hypoxia inducible factor (HIF-1) and vascular endothelial growth factor (VEGF) in rats with acute myocardial infarction (AMI) and its therapeutic effect were investigated. The rat models of acute myocardial infarction were established and divided into routine therapy, study, model, single drug and control group according to the treatment plan, with 10 cases in each group. Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentration of HIF-1 and VEGF in serum of rats before treatment (T0), and 3 days (T1), 5 days (T2) and 7 days (T3) after treatment, and the cardiac function was measured at the same time. The concentrations of HIF-1 and VEGF in serum of the study group and the routine therapy group after treatment were significantly higher than those before treatment. The concentrations of HIF-1 and VEGF in serum of model group at T0 were significantly lower than those at T3 (P<0.05). After treatment, the concentrations of HIF-1 and VEGF in serum of the study group were significantly higher than those of the routine therapy, the model and the control group (P<0.05). One week after administration, there were significant differences in the left ventricular function among the five groups (P<0.001). The left ventricular function in the study group was better than that in the routine therapy, model and control group. The levels of HIF-1 and VEGF in the serum of rats with myocardial infarction were negatively correlated with LVIDs and LVIDd, and positively correlated with LVEF% and LVFS%. In conclusion, atorvastatin combined with routine therapy can better reduce serum HIF-1 and VEGF levels and improve the left ventricular function in rats than routine therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Atorvastatin combined with routine therapy on HIF-1, VEGF concentration and cardiac function in rats with acute myocardial infarction

Zhang

2020

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Blood flow to the heart can become blocked due to the build-up of cholesterol and the formation of a blood clot in the heart's arteries. With cardiovascular events such as acute myocardial infarction, timing is essential in determining a patient's clinical outcome (Otto 2019). Evidence shows that shorter times between a myocardial infarction event and treatment are associated with lower mortality rates (Brunetti et al 2017).…”

Section: Cardiologymentioning

confidence: 99%

The potential socio-economic impact of telemedicine in Canada

2021

View full text Add to dashboard Cite

is a not-for-profit research organisation that helps improve policy and decision making through research and analysis. To learn more about RAND Europe, visit www.randeurope.org. Research IntegrityOur mission to help improve policy and decision making through research and analysis is enabled through our core values of quality and objectivity and our unwavering commitment to the highest level of integrity and ethical behaviour. To help ensure our research and analysis are rigorous, objective, and nonpartisan, we subject our research publications to a robust and exacting quality-assurance process; avoid both the appearance and reality of financial and other conflicts of interest through staff training, project screening, and a policy of mandatory disclosure; and pursue transparency in our research engagements through our commitment to the open publication of our research findings and recommendations, disclosure of the source of funding of published research, and policies to ensure intellectual independence. For more information, visit www.rand.org/about/principles. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.

show abstract

Heartbeat: Improving acute myocardial infarction outcomes in women

Cited by 2 publications

References 8 publications

Atorvastatin combined with routine therapy on HIF-1, VEGF concentration and cardiac function in rats with acute myocardial infarction

Atorvastatin combined with routine therapy on HIF-1, VEGF concentration and cardiac function in rats with acute myocardial infarction

The potential socio-economic impact of telemedicine in Canada

Contact Info

Product

Resources

About