2020
DOI: 10.1167/tvst.9.13.33
|View full text |Cite
|
Sign up to set email alerts
|

Heartbeat-Induced Corneal Axial Displacement and Strain Measured by High Frequency Ultrasound Elastography in Human Volunteers

Abstract: Purpose The purpose of this study was to establish in vivo data acquisition and processing protocols for repeatable measurements of heartbeat-induced corneal displacements and strains in human eyes, using a high-frequency ultrasound elastography method, termed ocular pulse elastography (OPE). Methods Twenty-four volunteers with no known ocular diseases were recruited for this study. Intraocular pressure (IOP) and ocular pulse amplitude (OPA) were measured using a PASCAL… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
23
2

Year Published

2021
2021
2024
2024

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 15 publications
(25 citation statements)
references
References 52 publications
0
23
2
Order By: Relevance
“…To translate these measurements to truly quantitative results, we need to quantify the stress acting upon the cornea due to either compression or the ocular pulse in addition to the strain. One way to perform this assessment is by quantifying the IOP in vivo , which may be performed using dynamic contour tonometry ( 6 ). Measuring the change in IOP as a response to the compression OCE measurement or recording the change in IOP due to the ocular pulse could be useful in quantifying corneal stress and translating strain into a quantitative biomechanical parameter ( 15 ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…To translate these measurements to truly quantitative results, we need to quantify the stress acting upon the cornea due to either compression or the ocular pulse in addition to the strain. One way to perform this assessment is by quantifying the IOP in vivo , which may be performed using dynamic contour tonometry ( 6 ). Measuring the change in IOP as a response to the compression OCE measurement or recording the change in IOP due to the ocular pulse could be useful in quantifying corneal stress and translating strain into a quantitative biomechanical parameter ( 15 ).…”
Section: Discussionmentioning
confidence: 99%
“…Elastography has been demonstrably effective for in vivo assessment of corneal mechanical properties. Ultrasound elastography has been previously performed in humans using ultrasound surface wave elastography (USWE) and ocular pulse elastography (OPE) ( 5 , 6 ). However, ultrasonic shear wave techniques typically suffer from poor contrast and a low resolution that can limit their effectiveness for imaging the small, thin ocular tissues.…”
Section: Introductionmentioning
confidence: 99%
“…the ocular pulse). 35,36 The results from the current study may lay a foundation for future in vivo studies to better understand the biomechanical mechanisms in KC development and progression.…”
Section: Radialmentioning
confidence: 83%
“…Non-invasive OCE measurements are however still challenging in the eye and have essentially been limited to the cornea in human subjects in-vivo [ 24 ]. Compared to standard OCE which uses an external pulse source, our method relies on the natural cardiac pulsation to investigate tissue deformation, similarly to recent work reported on passive elastography in the cornea in humans [ 37 ] and in animal models [ 36 ]. While such method does not provide information on the elastic modulus (the force exerted on the tissue is unknown), it gives interesting insights on retinal tissue motion over the range of several seconds.…”
Section: Discussionmentioning
confidence: 99%
“…While the first study focuses on the analysis of mechanical shear wave propagation, the second study is based on the calculation of tissue deformation and strain using the LSM over time. In-vivo heartbeat induced corneal strain measurements were also recently demonstrated in human eye using ultrasound elastography [ 37 ]. Similarly, several human in-vivo studies using PhS-OCT also focused on the investigation of deformation in corneal or retinal tissue under pulsation.…”
Section: Introductionmentioning
confidence: 99%