Mathematically study mass transfer phenomena involving chemical reactions in the flow of Sisko Ferro nanofluids through the porous surface. Three ferronano particles, manganese-zinc ferrite (Mn1/2Zn1/2Fe2O4), cobalt ferrite (CoFe2O4), and nickel–zinc ferrite (Ni–Zn Fe2O4) are considered with water (H2O) and ethylene glycol (C2H6O2) as base liquids. Appropriate resemblance transitions are used to convert the governing system of a nonlinear PDE to a linear ODE. The Runge–Kutta method, as extended by the shooting technique, is used to accomplish the reduction governing equations. The effects of various associated parameters on fluid concentration and mass transfer rate are investigated: magnetic criterion (M), Siskofluid material factor (A), Solid volume fraction (ϕ) for nanofluids, permeability parameter (Rp), Chemical reaction criterion (γ), Brownian motion factor (Nb), and Thermophoretic parameters (Nt). The current findings indicate that the diffusion proportion of Sisko Ferronanofluid Ni–Zn Fe2O4–H2O and CoFe2O4–H2O is higher than that of Ni–Zn Fe2O4–C2H6O2 and CoFe2O4–C2H6O2 respectively but it is opposite in the case of Mn–Zn ferrite. The comparison study was carried out to validate the precision of the findings.