Die-cutting tools have been widely applied in industrial production. However, different forms of failure on a blade, such as wear and fracture, can greatly reduce its service life. In this research, the die-cutting tool was selected as the object, a mixture of high speed steel powder and 304 stainless steel powder was coated as a gradient cladding layer onto the surface of AISI/SAE 1045 steel by laser cladding. The central composition design of the response surface methodology was adopted to establish a mathematical model between the pore area of the multi-layer, multi-track cladding, and its processing parameters: Laser Power (LP), Scanning Speed (SS), Gas Flow (GF), and Overlapping Rate (OR). This model was validated by variance analysis and inspection indicators. The actual experiment value by processing parameters optimization for achieving the smallest pore area showed a 4.41% error compared with the predicted value. The internal structure of the cladding layer is uniform. The defects, such as pores and cracks, meet the requirements. The wear resistance on the cutting edge is about 4.5 times compared with the substrate. The results provide a theoretical guidance for the controlling and prediction of the laser cladding forming quality on a two-dimensional gradient material and the optimization of the processing parameters.