Heat exchange and temperature calculation in thick-film semiconductor gas sensor systems

Giberti, A; Benetti, Michele; Carotta, M.C.; Guidi, V.; Malagù, C.; Martinelli, G.

doi:10.1016/j.snb.2007.07.129

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…All sensors were fired to a temperature of 650 • C and worked at a temperature set to 450 • C to activate the semiconductor layer, allowing chemoresistivity to occur. As shown in the literature [9,10,12], this high temperature does not affect substantially the analyte's composition nor the laminarity of the flux entering the sensing chambers. The sensors listed above were chosen according to their capability of recognizing tumor markers, which was assessed in previous research by using standard pure gases, feces [5], and blood [9].…”

Section: Scent B1 Devicementioning

confidence: 53%

Colorectal Cancer Study with Nanostructured Sensors: Tumor Marker Screening of Patient Biopsies

et al. 2020

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Despite the great progress in screening techniques and medical treatments, colorectal cancer remains one of the most widespread cancers in both sexes, with a high death rate. In this work, the volatile compounds released from human colon cancer tissues were detected by a set of four different chemoresistive sensors, made with a nanostructured powder of metal-oxide materials, inserted into an innovative patented device. The sensor responses to the exhalation of a primary cancer sample and of a healthy sample (both of the same weight, collected during colorectal surgery from the intestine of the same patient) were statistically analyzed. The sensors gave reversible, reproducible, and fast responses for at least one year of continuous use, making them quite superior in respect to the existing diagnostic methods. Preliminary results obtained using principal component analysis of the sensor responses to samples removed from 13 patients indicate that the nanostructured sensors employed in this study were able to distinguish between healthy and tumor tissue samples with coherent responses (the discrimination power of the most sensitive sensor was about 17%), highlighting a strong potential for clinical practice.

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Section: Scent B1 Devicementioning

confidence: 53%

Colorectal Cancer Study with Nanostructured Sensors: Tumor Marker Screening of Patient Biopsies

et al. 2020

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“…All the sensors used here worked at the temperature of 450 °C to fully activate the sensing layer and maximize the sensor detection capabilities [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Tin, Titanium, Tantalum, Vanadium and Niobium Oxide Based Sensors to Detect Colorectal Cancer Exhalations in Blood Samples

et al. 2021

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User-friendly, low-cost equipment for preventive screening of severe or deadly pathologies are one of the most sought devices by the National Health Services, as they allow early disease detection and treatment, often avoiding its degeneration. In recent years more and more research groups are developing devices aimed at these goals employing gas sensors. Here, nanostructured chemoresistive metal oxide (MOX) sensors were employed in a patented prototype aimed to detect volatile organic compounds (VOCs), exhaled by blood samples collected from patients affected by colorectal cancer and from healthy subjects as a control. Four sensors, carefully selected after many years of laboratory tests on biological samples (cultured cells, human stools, human biopsies, etc.), were based here on various percentages of tin, tungsten, titanium, niobium, tantalum and vanadium oxides. Sensor voltage responses were statistically analyzed also with the receiver operating characteristic (ROC) curves, that allowed the identification of the cut-off discriminating between healthy and tumor affected subjects for each sensor, leading to an estimate of sensitivity and specificity parameters. ROC analysis demonstrated that sensors employing tin and titanium oxides decorated with gold nanoparticles gave sensitivities up to 80% yet with a specificity of 70%.

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“…The variety of sensors chosen lays upon the will to verify if chemoresistive sensors can detect variations as a whole technology, or if only some particular semiconductors can be used for screening/detection purposes, and to visualize possible correlations between their response behaviors. Further details in the sensors' functioning, the differences between the various semiconductor materials, and their characterizations can be found in literature [1][2][3][4][5][6][7][33][34][35][36][37][38][39][40][41][42][43][44][45]. The responses are standardly defined as the average value between three output voltages measured by the sensor from the same sample, as shown in the following formula [6]:…”

Section: Sensors Technologymentioning

confidence: 99%

Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples

Landini

Anania

Astolfi

et al. 2020

Sensors

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Preventive screening does not only allow to preemptively intervene on pathologies before they can harm the host; but also to reduce the costs of the intervention itself; boosting the efficiency of the NHS (National Health System) by saving resources for other purposes. To improve technology advancements in this field; user-friendly yet low-cost devices are required; and various applications for gas sensors have been tested and proved reliable in past studies. In this work; cell cultures and blood samples have been studied; using nanostructured chemoresistive sensors; to both verify if this technology can reliably detect tumor markers; and if correlations between responses from tumor line metabolites and the screening outcomes on human specimens could be observed. The results showed how sensors responded differently to the emanations from healthy and mutant (for cells) or tumor affected (for blood) samples, and how those results were consistent between them, since the tumoral specimens had higher responses compared to the ones of their healthy counterparts. Even though the patterns in the responses require a bigger population to be defined properly; it appeared that the different macro-groups between the same kind of samples are distinguishable from some of the sensors chosen in the study; giving promising outcomes for further research.

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Heat exchange and temperature calculation in thick-film semiconductor gas sensor systems

Cited by 6 publications

References 8 publications

Colorectal Cancer Study with Nanostructured Sensors: Tumor Marker Screening of Patient Biopsies

Colorectal Cancer Study with Nanostructured Sensors: Tumor Marker Screening of Patient Biopsies

Tin, Titanium, Tantalum, Vanadium and Niobium Oxide Based Sensors to Detect Colorectal Cancer Exhalations in Blood Samples

Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples

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