Heat-Generating Mn0.5Zn0.5Fe2O4/MWCNTs nanocomposites for enhancing hyperthermia efficacy in magnetic hyperthermia applications

Shen, Kaiming; Yan, Yuanyuan; Gao, Wei; Li, Haojie; Chen, Wanyi; He, Zhiping; Li, Lixian

doi:10.1016/j.jallcom.2022.166806

Cited by 12 publications

(10 citation statements)

References 49 publications

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“…The magnetocaloric effect exhibits an initial increasing trend followed by a significant decrease. Previous studies have shown that both MZFC-2 and MZFC-4 exhibit good magnetothermal effects . Based on the findings of this paper, the photothermal conversion effect of MZFC-4 is significantly better than that of MZFC-2.…”

Section: Resultssupporting

confidence: 61%

“…Previous studies have shown that both MZFC-2 and MZFC-4 exhibit good magnetothermal effects. 64 Based on the findings of this paper, the photothermal conversion effect of MZFC-4 is significantly better than that of MZFC-2. Therefore, MZFC-4 was selected as the optimal sample for magnetothermalphotothermal synergistic therapy in the following experiments.…”

Section: Photothermal and Magneticmentioning

confidence: 66%

“…Our previous published work showed that using doped carbon nanotubes can improve the magnetocaloric effect, but with the continuous increase of MWCNTs. The magnetocaloric effect exhibits an initial increasing trend followed by a significant decrease.…”

Section: Resultsmentioning

confidence: 98%

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Multiwalled Carbon Nanotubes Decorated with Mn_0.5Zn_0.5Fe₂O₄ Nanoparticles for Magneto-Photothermal Cancer Therapy

Shen

Yan

Xue

et al. 2023

ACS Appl. Nano Mater.

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Alternative cancer treatments such as photothermal therapy (PTT) and magnetic hyperthermia (MHT) techniques have been studied to show promising potential as supplementary modalities. However, such techniques have their own limitations; for instance, highly concentrated intratumoral injections of magnetic nanoparticles are required to compensate their low specific loss power under safe and low magnetic field intensity for the MHT, while the PTT has limitations in the treatment of deep-seated tumors due to low light penetration. Here, the decoration of the multi-walled carbon nanotube (MWCNT) surface by magnetic nanoparticles (≈8.5 nm) was achieved by a hydrothermal method and the development of MWCNT/Mn0.5Zn0.5Fe2O4 (MZFC) hybrids for magneto-photothermal dual-mode cancer therapy. The obtained specific loss power of the MZFC hybrids is found to be at least 1 order of magnitude higher, with improvement from ∼19 W/g to 225 W/g, under the excitation of both an AMF with a magnetic field intensity of 6.4 kA/m and a frequency of 300 kHz and a simultaneous NIR laser of 0.5 W/cm2 irradiation. The synergistic utilization of the photothermal and magnetic properties of MZFC effectively diminishes the required magnetic field amplitude and NIR laser power density. Our in vitro cell experiments confirmed that the thermal effects mediated by the MZFC after endocytosis delivered enhanced cytotoxicity in the presence of dual excitation of NIR laser and AMF. These findings indicate that MZFC nanohybrids possess significant potential as targeted nanoheating agents for hyperthermia applications.

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Section: Resultssupporting

confidence: 61%

Section: Photothermal and Magneticmentioning

confidence: 66%

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Multiwalled Carbon Nanotubes Decorated with Mn_0.5Zn_0.5Fe₂O₄ Nanoparticles for Magneto-Photothermal Cancer Therapy

Shen

Yan

Xue

et al. 2023

ACS Appl. Nano Mater.

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“…Mn-Zn ferrite (Mn 1-x Zn x Fe 2 O 4 ) has recently been discovered to have the advantages of high saturation magnetization intensity, good biocompatibility, and low toxicity, and has been widely concerned with and studied in magnetic hyperthermia for cancer [1][2][3]. The heat generation mechanism of ferrite primarily includes electromagnetic energy consumption [4], which includes eddy current loss (P e ), hysteresis loss (P h ), and residual loss (P c ).…”

Section: Introductionmentioning

confidence: 99%

The Correlation Between the Temperature Control Effect and Thermoelectric Properties of CNTs/Mn-Zn Ferrite Composites

Zhang

2023

J. Phys.: Conf. Ser.

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Mn-Zn ferrite has been widely used in cancer therapy. In this paper, CNTs/Mn-Zn ferrite composites with different CNT contents were synthesized using the co-precipitation process and then sintered into bulk materials by SPS. The nanoparticles have good heating and temperature control effects under an alternating magnetic field. Furthermore, the sintered composites have thermoelectric properties. The correlation between the temperature control mechanism and the thermoelectric properties of manganese zinc ferrite for thermotherapy is investigated.

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“…To achieve the desired effect there is a need to overcome the major obstacle of developing magnetic nanoparticles with a high specific absorption rate (SAR) which operates within a safe tolerance field. 5,6 Previous studies have focused on the optimization of singledomain magnetic nanoparticle properties, such as by tuning the shape, size, composition, and magnetic anisotropy to enhance their efficiency in MHT. [7][8][9] The improved magnetic properties of ferrimagnetic iron oxide nanoparticles have resulted in a significant improvement of SAR values, increasing them from approximately ∼10 to ∼1000 W g −1 .…”

Section: Introductionmentioning

confidence: 99%

Hollow spherical Mn_0.5Zn_0.5Fe₂O₄ nanoparticles with a magnetic vortex configuration for enhanced magnetic hyperthermia efficacy

Shen,

Li,

Tan

et al. 2023

Nanoscale

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Heat-Generating Mn0.5Zn0.5Fe2O4/MWCNTs nanocomposites for enhancing hyperthermia efficacy in magnetic hyperthermia applications

Cited by 12 publications

References 49 publications

Multiwalled Carbon Nanotubes Decorated with Mn_0.5Zn_0.5Fe₂O₄ Nanoparticles for Magneto-Photothermal Cancer Therapy

Multiwalled Carbon Nanotubes Decorated with Mn_0.5Zn_0.5Fe₂O₄ Nanoparticles for Magneto-Photothermal Cancer Therapy

The Correlation Between the Temperature Control Effect and Thermoelectric Properties of CNTs/Mn-Zn Ferrite Composites

Hollow spherical Mn_0.5Zn_0.5Fe₂O₄ nanoparticles with a magnetic vortex configuration for enhanced magnetic hyperthermia efficacy

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Heat-Generating Mn0.5Zn0.5Fe2O4/MWCNTs nanocomposites for enhancing hyperthermia efficacy in magnetic hyperthermia applications

Cited by 12 publications

References 49 publications

Multiwalled Carbon Nanotubes Decorated with Mn0.5Zn0.5Fe2O4 Nanoparticles for Magneto-Photothermal Cancer Therapy

Multiwalled Carbon Nanotubes Decorated with Mn0.5Zn0.5Fe2O4 Nanoparticles for Magneto-Photothermal Cancer Therapy

The Correlation Between the Temperature Control Effect and Thermoelectric Properties of CNTs/Mn-Zn Ferrite Composites

Hollow spherical Mn0.5Zn0.5Fe2O4 nanoparticles with a magnetic vortex configuration for enhanced magnetic hyperthermia efficacy

Contact Info

Product

Resources

About

Multiwalled Carbon Nanotubes Decorated with Mn_0.5Zn_0.5Fe₂O₄ Nanoparticles for Magneto-Photothermal Cancer Therapy

Multiwalled Carbon Nanotubes Decorated with Mn_0.5Zn_0.5Fe₂O₄ Nanoparticles for Magneto-Photothermal Cancer Therapy

Hollow spherical Mn_0.5Zn_0.5Fe₂O₄ nanoparticles with a magnetic vortex configuration for enhanced magnetic hyperthermia efficacy