Heat generation associated with synaptic transmission in the mammalian superior cervical ganglion

Kusano, Kazuo; Tasaki, Ichiji

doi:10.1002/jnr.490250214

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…Another established process, first observed by Abott et al (1958) is a heat production concomitant to the action potential followed by partial (45-85%) reabsorption of the heat (Howarth et al 1968(Howarth et al , 1979. Recent measurements made in the garfish olfactory nerves using synthetic pyroelectric polymers as heat sensors show that the thermal response also starts and peaks with the action potential resulting in a temperature rise by 23 µ • C (Tasaki et al 1989, Tasaki and Byrne 1987, 1991, Kusano and Tasaki 1990a, Tasaki and Iwasa 1981) (figure 6). Such heat release has also been observed during spreading depression (Tasaki and Byrne 1991).…”

Section: Heat Release and Phase-transitionmentioning

confidence: 99%

The ‘wet mind’: water and functional neuroimaging

Bihan¹

2007

Phys. Med. Biol.

294

267

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Functional neuroimaging has emerged as an important approach to study the brain and the mind. Surprisingly, although they are based on radically different physical approaches both positron emission tomography (PET) and magnetic resonance imaging (MRI) make brain activation imaging possible through measurements involving water molecules. So far, PET and MRI functional imaging have relied on the principle that neuronal activation and blood flow are coupled through metabolism. However, a new paradigm has emerged to look at brain activity through the observation with MRI of the molecular diffusion of water. In contrast with the former approaches diffusion MRI has the potential to reveal changes in the intrinsic water physical properties during brain activation, which could be more intimately linked to the neuronal activation mechanisms and lead to an improved spatial and temporal resolution. However, this link has yet to be fully confirmed and understood. To shed light on the possible relationship between water and brain activation, this introductory paper reviews the most recent data on the physical properties of water and on the status of water in biological tissues, and evaluates their relevance to brain diffusion MRI. The biophysical mechanisms of brain activation are then reassessed to reveal their intimacy with the physical properties of water, which may come to be regarded as the 'molecule of the mind'.

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Section: Heat Release and Phase-transitionmentioning

confidence: 99%

The ‘wet mind’: water and functional neuroimaging

Bihan¹

2007

Phys. Med. Biol.

294

267

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“…The methods of isolating sympathetic ganglia and preparing physiological saline and various test solutions are similar to those employed in our study of thermal responses of the SCG (Kusano and Tasaki, 1990). All the experiments were carried out at room temperature (22-24°C).…”

Section: Preparations Salines and Drugsmentioning

confidence: 99%

Mechanical changes associated with synaptic transmission in the mammalian superior cervical ganglion

Kusano

Tasaki

1990

J of Neuroscience Research

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Mechanical changes in the superior cervical ganglion (SCG) of the guinea pig, evoked by stimulating the pre- or postganglionic nerve, were determined by using a mechano-electric transducer. The mechanical change evoked by either one of these nerves was monophasic, an initial phase of rapid swelling (about 1 dyn/cm2) being followed by a slow relaxation. The mechanism of these mechanical changes was examined by treating the preparations with agents which are known to suppress or facilitate synaptic transmission in the SCG. Mechanical changes elicited by preganglionic nerve stimulation were suppressed by agents that reversibly block ganglionic transmission (Ca2(+)-free high Mg2+, d-tubocurarine, hexamethonium, TEA, TTX). On the other hand, agents which are known to facilitate synaptic transmission (high Ca2+) increased both the amplitude and the duration of swelling. In a Ba2(+)-containing medium, a large, long-lasting shrinkage of the ganglion was observed. It is suggested that the mechanical changes recorded in this study are associated with postsynaptic electro-genesis.

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Infrared Imaging of Brain Function

Gorbach

1993

Advances in Experimental Medicine and Biology

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Heat generation associated with synaptic transmission in the mammalian superior cervical ganglion

Cited by 5 publications

References 32 publications

The ‘wet mind’: water and functional neuroimaging

The ‘wet mind’: water and functional neuroimaging

Mechanical changes associated with synaptic transmission in the mammalian superior cervical ganglion

Infrared Imaging of Brain Function

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