Heat-induced phase separation of alkali chloride–HFIP–water mixtures

Hexafluoroisopropanol as a Low‐Boiling Extraction Solvent for 5‐Hydroxymethylfurfural Production

“…To investigate HFIP/water mixtures containing electrolytes, 5 mL of HFIP was mixed with 5 mL of water containing different concentrations of the electrolyte. As the electrolyte, NaCl was chosen because of the results obtained previously by us and Takamuku et al …”

“…Thus, NaCl was able to separate a mixture of water and HFIP with a definite ratio of 90:10 by volume from the HFIP phase. This incomplete separation of water and HFIP by NaCl may be explained by hydrogen‐bonding interactions of HFIP with water that cannot be completely suppressed by NaCl …”

“…In contrast, the volume of water in the lower HFIP-richp hase decreased upon increasing NaCl from 40 %a t3 0gL À1 to 20 %a t 300 gL À1 .T hus,NaCl was able to separate amixture of water and HFIP with ad efinite ratio of 90:10 by volume from the HFIP phase.T his incomplete separationo fw ater and HFIP by NaCl may be explained by hydrogen-bonding interactions of HFIP with water that cannot be completely suppressed by NaCl. [16] Thes alting out effect in this mixture did not lead to complete separation of HFIP from water, whichh as to be kept in mind.B ecause phase separation stagnated at higher NaCl concentrations,1 00 gL À1 NaCl was usedi nf uture experiments.…”

“…This was also studied in detail for the MIBK and 1‐butanol systems in recent work, which showed that this effect was rather complex . In the case of the HFIP system, this effect causes water to separate from the HFIP‐rich phase to form a HFIP‐poor, salt‐rich phase . Until now, there have not been any investigations into the use of HFIP in HMF synthesis or the use of HFIP as an extraction solvent in general.…”

“…[15] In the case of the HFIP system,t his effect causes water to separate from the HFIP-rich phase to form aH FIP-poor, salt-rich phase. [16] Until now,t here have not been any investigations into the use of HFIP in HMF synthesis or the use of HFIP as an extractionsolvent in general.…”