A 72-year-old man with type C cirrhosis was admitted to our hospital for refractory esophageal varices. Prophylactic endoscopic injection sclerotherapy (EIS) was performed twice in August 2000 for high-risk esophageal varices at an outside hospital. However, a therapeutic effect was not attained. Endoscopic finding revealed F1, Cb, RC (-) at the gastroesophageal junction to approximately a 5-cm oral site, and F3, Cb, RC (+) varices at the upper site from the 5-cm oral site of the gastroesophageal junction. Color flow images were obtained of the posterior branch of the left gastric vein and revealed an inflow-type perforating vein about a site 5 cm oral from the gastroesophageal junction. Color flow images of esophageal varices were detected with endoscopic color Doppler ultrasonography. Color flow images of out-flowingtype perforating veins were discerned in the middle esophagus. The vessel images of intramural esophageal varices were clearly delineated via an ultrasonic microprobe and showed a perforating vein with a diameter of 4 mm. We performed EIS with an attached balloon to occlude the out-flowing-type perforating veins with 5% ethanolamine oleate with iopamidol. Seven days after the first EIS, thromboses were observed in the intramural esophageal varices and in the inflow type-perforating veins via ultrasonic microprobe. We exchanged the hemodynamics of this esophageal variceal case with blockade of the inflow-type perforating vein. Next, we successfully performed EIS, and achieved the blockade of passageways, including the palisade veins. Forty days after EIS, endoscopic findings revealed disappearance of the esophageal varices.