Heat Production of Atherosclerotic Plaques and Inflammation Assessed by the Acute Phase Proteins in Acute Coronary Syndromes

Stefanadis, Christodoulos; Diamantopoulos, Leonidas; Dernellis, John; Economou, Emmanuel; Tsiamis, Eleftherios; Toutouzas, Konstantinos; Vlachopoulos, Charalambos; Toutouzas, Pavlos

doi:10.1006/jmcc.1999.1049

Cited by 102 publications

(77 citation statements)

References 23 publications

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“…Current thinking suggests systemic inflammation is associated with ischemic heart diseases, including AMI. 14,15) Previous some studies have demonstrated that CRP, an acute phase representative protein, is associated with various complications including cardiac events in AMI. 16,17) SAA, also an important acute phase inflammatory protein, has an expanded dynamic range with different kinetics compared with CRP and is reported to be a more sensitive indicator of inflammation in some noncardiovascular inflammatory conditions.…”

Section: Discussionmentioning

confidence: 99%

<b>The Etiology of ‘Smoker’s Paradox’ in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation</b>

Katayama¹,

Iwasaki²,

Sakoda³

et al. 2008

Int. Heart J.

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SUMMARYDespite increased risk for coronary artery disease and acute myocardial infarction (AMI), prior studies have found that smokers with AMI have lower mortality rates than nonsmokers, a phenomenon often termed 'smoker's paradox'. The present study was designed to examine the etiology of 'smoker's paradox', especially with respect to the association with inflammation.The subjects included 528 consecutive AMI patients who were admitted within 24 hours of onset and underwent successful coronary intervention. Of the 528 subjects, 232 (44%) were smokers.The cardiac mortality rates over a 6 month period was significantly lower in the smoking group than the nonsmoking group (3% versus 9%, P = 0.01). There were significantly more male patients in the smoking group, and the smoking group was significantly younger than the nonsmoking group (P < 0.0001). The value of high sensitivity C-reactive protein (hs-CRP) on admission and 24 hours after onset, and serum amyloid A protein (SAA) were significantly higher, and acute phase BNP was significantly lower (hs-CRP on admission 1.36 ± 1.03 mg/dL versus 0.75 ± 0.82 mg/dL, P = 0.02, hs-CRP at 24 hours 3.86 ± 4.32 mg/dL versus 2.90 ± 3.46 mg/dL, P = 0.008, SAA; 288 ± 392 µg/dL versus 176 ± 206 µg/dL, P < 0.05, BNP; 248 ± 342 pg/mL versus 444 ± 496 pg/mL, P = 0.0002) in the smoking group than in the nonsmoking group. The early ST-segment resolution rate was higher in the smoking group compared with the nonsmoking group (80% versus 66%, P = 0.003).The reason why smokers with AMI have lower mortality rates than nonsmokers, the so-called 'smoker's paradox', is believed to be because smoking induces inflammation and smokers may have less damage to microvascular function after primary percutaneous coronary intervention. (Int Heart J 2008; 49: 13-24) Key words: Myocardial infarction, Smoking, Inflammation EVEN though many epidemiologic studies have shown that cigarette smoking is associated with higher rates of myocardial infarction and death from coronary From the

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Section: Discussionmentioning

confidence: 99%

<b>The Etiology of ‘Smoker’s Paradox’ in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation</b>

Katayama¹,

Iwasaki²,

Sakoda³

et al. 2008

Int. Heart J.

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show abstract

“…19,20 Previous studies have demonstrated that CRP, an acute phase representative protein, is associated with various complications, including cardiac events 21 and left ventricular dysfunction 22 in AMI. We have reported that acutephase plasma SAA concentrations after successful direct PCI are closely related to major adverse complications, including mortality 23 and the present study demonstrates that SAA is a predictor of SAT after primary stenting.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Sub-Acute Stent Thrombosis in Acute Myocardial Infarction Patients Following Primary Coronary Stenting With Bare Metal Stent

Katayama

Nakashima

Takagi

et al. 2006

Circ J

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“…Reprinted with permission from Libby P et al 6 because a thermography catheter is clearly measuring heat arising from the plaque alone and not from other parts of the body. 16 Thermal techniques might potentially be combined with intravascular ultrasound or optical coherence tomography to provide both functional and anatomic information. 23 …”

Section: Temperature Heterogeneitymentioning

confidence: 99%

Inflammation as a Cardiovascular Risk Factor

2004

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Heat Production of Atherosclerotic Plaques and Inflammation Assessed by the Acute Phase Proteins in Acute Coronary Syndromes

Cited by 102 publications

References 23 publications

<b>The Etiology of ‘Smoker’s Paradox’ in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation</b>

<b>The Etiology of ‘Smoker’s Paradox’ in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation</b>

Predictors of Sub-Acute Stent Thrombosis in Acute Myocardial Infarction Patients Following Primary Coronary Stenting With Bare Metal Stent

Inflammation as a Cardiovascular Risk Factor

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Heat Production of Atherosclerotic Plaques and Inflammation Assessed by the Acute Phase Proteins in Acute Coronary Syndromes

Cited by 102 publications

References 23 publications

<b>The Etiology of &lsquo;Smoker&rsquo;s Paradox&rsquo; in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation</b>

<b>The Etiology of &lsquo;Smoker&rsquo;s Paradox&rsquo; in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation</b>

Predictors of Sub-Acute Stent Thrombosis in Acute Myocardial Infarction Patients Following Primary Coronary Stenting With Bare Metal Stent

Inflammation as a Cardiovascular Risk Factor

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Resources

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<b>The Etiology of ‘Smoker’s Paradox’ in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation</b>

<b>The Etiology of ‘Smoker’s Paradox’ in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation</b>