Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway

Zhang, Lan; Zeng, Hongliang; Jiang, Ling; Fu, Chuhan; Zhang, Yushan; Hu, Yibo; Zhang, Xiaolin; Li, Zhu; Zhang, Fan; Huang, Jinhua; Chen, Jing; Zeng, Qinghai

doi:10.1016/j.isci.2023.106749

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…The phosphatidylinositol signaling system (oas04070) controls melanocyte proliferation and differentiation [146]. The VEGF signaling pathway (oas04370) affects melanin synthesis [147]. Carotenoids produce yellow, orange, and red colors, and retrograde endocannabinoid signaling (oas04723) may be associated with carotenoid-based coloration [148].…”

Section: Go Terms and Pathways Associated With Non-white Woolmentioning

confidence: 99%

Whole Genome Resequencing Reveals Selection Signals Related to Wool Color in Sheep

Zhang,

Jin,

et al. 2023

Animals

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Wool color is controlled by a variety of genes. Although the gene regulation of some wool colors has been studied in relative depth, there may still be unknown genetic variants and control genes for some colors or different breeds of wool that need to be identified and recognized by whole genome resequencing. Therefore, we used whole genome resequencing data to compare and analyze sheep populations of different breeds by population differentiation index and nucleotide diversity ratios (Fst and θπ ratio) as well as extended haplotype purity between populations (XP-EHH) to reveal selection signals related to wool coloration in sheep. Screening in the non-white wool color group (G1 vs. G2) yielded 365 candidate genes, among which PDE4B, GMDS, GATA1, RCOR1, MAPK4, SLC36A1, and PPP3CA were associated with the formation of non-white wool; an enrichment analysis of the candidate genes yielded 21 significant GO terms and 49 significant KEGG pathways (p < 0.05), among which 17 GO terms and 21 KEGG pathways were associated with the formation of non-white wool. Screening in the white wool color group (G2 vs. G1) yielded 214 candidate genes, including ABCD4, VSX2, ITCH, NNT, POLA1, IGF1R, HOXA10, and DAO, which were associated with the formation of white wool; an enrichment analysis of the candidate genes revealed 9 significant GO-enriched pathways and 19 significant KEGG pathways (p < 0.05), including 5 GO terms and 12 KEGG pathways associated with the formation of white wool. In addition to furthering our understanding of wool color genetics, this research is important for breeding purposes.

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Section: Go Terms and Pathways Associated With Non-white Woolmentioning

confidence: 99%

Whole Genome Resequencing Reveals Selection Signals Related to Wool Color in Sheep

Zhang,

Jin,

et al. 2023

Animals

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Melanin-based plumage coloration and melanin content in organs in the barn owl

Roulin,

Dubey,

Ito

et al. 2023

J Ornithol

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Although the evolutionary ecology of melanin pigments and melanin-based coloration has been studied in great details, particularly in birds, little is known about the function of melanin stored inside the body. In the barn owl Tyto alba, in which individuals vary in the degree of reddish pheomelanin-based coloration and in the size of black eumelanic feather spots, we measured the concentration in melanin pigments in seven organs. The eyes had by far the most melanin then the skin, pectoral muscle, heart, liver, trachea, and uropygial gland. The concentration in eumelanin was not necessarily correlated with the concentration in pheomelanin suggesting that their production can be regulated independently from each other. Redder barn owls had more pheomelanin in the skin and uropygial gland than white owls, while owls displaying larger black feather spots had more eumelanin in the skin than small-spotted owls. More data are required to evaluate whether melanin-based traits can evolve as an indirect response to selection exerted on melanin deposition in organs.

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Microplastics and Skin Aging: Disruption of Barrier Function and Induction of Fibroblast Senescence

Ouyang,

Wu,

Zhao

et al. 2024

Experimental Dermatology

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Microplastics (MPs) have emerged as a major concern among contemporary pollutants, but there is still limited knowledge regarding their impact on skin function. To address this issue, we conducted a transcriptome analysis on skin tissue that had been exposed to polystyrene (PS), which is one of the most prevalent type of MPs that can be absorbed through the skin. The results of our study, obtained through functional enrichment analysis and the experiment of treating HaCaT with PS, revealed that PS may have an effect on skin barrier function, specifically the permeability barrier through inhibiting keratinocyte differentiation. Additionally, PS also induced dysfunction in the extracellular matrix (ECM). Mechanistically, we observed that PS induced fibroblasts senescence and increased the secretion of senescence‐related characteristics. Furthermore, the expression of core genes related to the ECM, such as COL1A1, COL1A2 and SPP1, was found to be down‐regulated in PS‐treated fibroblasts. Moreover, an in vitro experiment provided evidence of the involvement of PPARγ in PS‐induced fibroblast senescence. In conclusion, our study has identified PS as a causal factor for skin barrier dysfunction. Additionally, PS induces fibroblast senescence, leading to ECM dysfunction and contributing to skin aging. These findings further strengthen the understanding and management of the effects of MPs on skin health.

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Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway

Cited by 3 publications

References 47 publications

Whole Genome Resequencing Reveals Selection Signals Related to Wool Color in Sheep

Whole Genome Resequencing Reveals Selection Signals Related to Wool Color in Sheep

Melanin-based plumage coloration and melanin content in organs in the barn owl

Microplastics and Skin Aging: Disruption of Barrier Function and Induction of Fibroblast Senescence

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