Heat-sensitive microbubbles for intraoperative assessment of cancer ablation margins

Huang, Jiwei; Xu, Jigeng; Xu, Ronald X.

doi:10.1016/j.biomaterials.2009.11.008

Cited by 65 publications

(50 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some PFC compounds have relatively low boiling points and readily evaporate upon stimulation by external energy sources. They have been used to fabricate droplets, bubbles, or capsules at micro and nano sizes in various applications of image guided therapy and controlled drug delivery [22][23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound mediated destruction of multifunctional microbubbles for image guided delivery of oxygen and drugs

Chang

Zhang

et al. 2016

Ultrasonics Sonochemistry

Self Cite

View full text Add to dashboard Cite

We synthesized multifunctional activatible microbubbles (MAMs) for ultrasound mediated delivery of oxygen and drugs with both ultrasound and fluorescence imaging guidance. Oxygen enriched perfluorocarbon (PFC) compound was encapsulated in liposome microbubbles (MBs) by a modified emulsification process. DiI dye was loaded as a model drug. The ultrasound targeted microbubble destruction (UTMD) process was guided by both ultrasonography and fluorescence imaging modalities. The process was validated in both a dialysis membrane tube model and a porcine carotid artery model. Our experiment results show that the UTMD process effectively facilitates the controlled delivery of oxygen and drug at the disease site and that the MAM agent enables ultrasound and fluorescence imaging guidance of the UTMD process. The proposed MAM agent can be potentially used for UTMD-mediated combination therapy in hypoxic ovarian cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Ultrasound mediated destruction of multifunctional microbubbles for image guided delivery of oxygen and drugs

Chang

Zhang

et al. 2016

Ultrasonics Sonochemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…When used as cavitation nuclei, phase-shift NDs a number of therapeutic applications, such as the targeted delivery of therapeutic agents (Rapoport et al 2010), enhanced HIFU therapy for cancer treatment (Zhang and Porter 2010), and gas embolotherapy, in which gas MBs selectively formed from liquid droplets are used to prevent blood flow to tumors (Qamar et al 2010). Additional applications for phase-shift NDs potentially lie in ultrasound molecular imaging, phase aberration correction, and intraoperative assessment of cancer ablation margins produced by thermal techniques (Haworth et al 2008;Huang et al 2010b;Sheeran et al 2013). Here, we compare how flowing phase-shift NDs and lipid-shelled MBs affect cavitation during FUS exposures.…”

Section: Comparison Of Cavitation With Flowing Polymer Mbs and Lipid-mentioning

confidence: 99%

Cavitation-Enhanced Thermal Effects and Applications

Zhang

Wan

Haar

2015

Cavitation in Biomedicine

View full text Add to dashboard Cite

“…[1][2][3][4][5][6] These microand nanoparticles are commonly prepared by a double emulsion process that encapsulates therapeutic and imaging cargos in a shell structure following a two-step procedure involving either water/oil/water or oil/water/oil phases. [7][8][9][10] However, the encapsulation efficiency of a double emulsion process heavily relies on the interfacial characteristics of the core/shell materials. For many hydrophilic drugs, it is difficult to achieve a high encapsulation rate.…”

Section: Introductionmentioning

confidence: 99%

Experimental design and instability analysis of coaxial electrospray process for microencapsulation of drugs and imaging agents

Zhang

et al. 2013

J. Biomed. Opt

View full text Add to dashboard Cite

Abstract. Recent developments in multimodal imaging and image-guided therapy requires multilayered microparticles that encapsulate several imaging and therapeutic agents in the same carrier. However, commonly used microencapsulation processes have multiple limitations such as low encapsulation efficiency and loss of bioactivity for the encapsulated biological cargos. To overcome these limitations, we have carried out both experimental and theoretical studies on coaxial electrospray of multilayered microparticles. On the experimental side, an improved coaxial electrospray setup has been developed. A customized coaxial needle assembly combined with two ring electrodes has been used to enhance the stability of the cone and widen the process parameter range of the stable cone-jet mode. With this assembly, we have obtained poly(lactide-co-glycolide) microparticles with fine morphology and uniform size distribution. On the theoretical side, an instability analysis of the coaxial electrified jet has been performed based on the experimental parameters. The effects of process parameters on the formation of different unstable modes have been studied. The reported experimental and theoretical research represents a significant step toward quantitative control and optimization of the coaxial electrospray process for microencapsulation of multiple drugs and imaging agents in multimodal imaging and image-guided therapy.

show abstract

Heat-sensitive microbubbles for intraoperative assessment of cancer ablation margins

Cited by 65 publications

References 34 publications

Ultrasound mediated destruction of multifunctional microbubbles for image guided delivery of oxygen and drugs

Ultrasound mediated destruction of multifunctional microbubbles for image guided delivery of oxygen and drugs

Cavitation-Enhanced Thermal Effects and Applications

Experimental design and instability analysis of coaxial electrospray process for microencapsulation of drugs and imaging agents

Contact Info

Product

Resources

About