Heat shock factor-independent heat control of transcription of the CTT1 gene encoding the cytosolic catalase T of Saccharomyces cerevisiae

Wieser, Rotraud; Adam, Gerhard; Wagner, Alina; Schüller, Christoph; Marchler, Gabriele H.; Ruis, Helmut; Krawiec, Z.; Biliński, T

doi:10.1016/s0021-9258(18)98912-x

Cited by 135 publications

(10 citation statements)

References 42 publications

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“…Previous studies have shown that high temperature induces H 2 O 2 defenses in a wide variety of organisms, including bacteria (Engelmann et al, 1995; Mossialos et al, 2006), yeasts (Deegenaars and Watson, 1997; Mitchell et al ., 2009; Wieser et al, 1991), plants (Hu et al, 2021; Nishizawa et al, 2006; Panchuk et al, 2002), cnidarians (Dash and Phillips, 2012), and human HeLa cells (Pallepati and Averill-Bates, 2010). Many of those examples could represent instances of enhancer sensing.…”

Section: Discussionmentioning

confidence: 99%

Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature

Servello

Fernandes

Eder

et al. 2022

Preprint

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Hydrogen peroxide is the most common reactive chemical that organisms face on the microbial battlefield. The rate with which hydrogen peroxide damages biomolecules required for life increases with temperature, yet little is known about how organisms cope with this temperature-dependent threat. Here, we show that Caenorhabditis elegans nematodes use temperature information perceived by sensory neurons to cope with the temperature-dependent threat of hydrogen peroxide produced by the pathogenic bacterium Enterococcus faecium. These nematodes preemptively induce the expression of specific hydrogen peroxide defenses in response to perception of high temperature by a pair of sensory neurons. These neurons communicate temperature information to target tissues expressing those defenses via an insulin/IGF1 hormone. This strategy, which we call “enhancer sensing,” is the first example of a multicellular organism inducing their defenses to a chemical when they sense an inherent enhancer of the reactivity of that chemical.

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Section: Discussionmentioning

confidence: 99%

Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature

Servello

Fernandes

Eder

et al. 2022

Preprint

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“…30,66 The mechanism of resistance of heat-shocked cells to oxidants is not known; however, transcription of the CTT1 gene is elevated by heat-shock, via STRE elements. 147 Therefore, the combination of increased catalase activity, the heat-shock-protein-encoding genes and other STRE-regulated genes may explain the observed resistance. In support of this idea, yeast lacking Cta1, Ctt1, Cu/ZnSOD, MnSOD and cytochrome c peroxidase were found to be less thermotolerant than wild-type cells, while over-expression of these genes conferred a degree of protection towards lethal heat-shock.…”

Section: Heat-shock Responsementioning

confidence: 99%

Oxidative stress responses of the yeastSaccharomyces cerevisiae

Jamieson

1998

Yeast

663

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All aerobically growing organisms suffer exposure to oxidative stress, caused by partially reduced forms of molecular oxygen, known as reactive oxygen species (ROS). These are highly reactive and capable of damaging cellular constituents such as DNA, lipids and proteins. Consequently, cells from many different organisms have evolved mechanisms to protect their components against ROS. This review concentrates on the oxidant defence systems of the budding yeast Saccharomyces cerevisiae , which appears to have a number of inducible adaptive stress responses to oxidants, such as H2 O2 , superoxide anion and lipid peroxidation products. The oxidative stress responses appear to be regulated, at least in part, at the level of transcription and there is considerable overlap between them and many diverse stress responses, allowing the yeast cell to integrate its response towards environmental stress. © 1998 John Wiley & Sons, Ltd.

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“…Among the many environmental stress response genes that were upregulated in the evolved strain H7, CTT1 that encodes cytosolic catalase T was up-regulated by 5.37-fold in H7, compared to the reference strain. Cytosolic catalase T is known to have a role in protection from oxidative damage caused by H 2 O 2 ( Wieser et al, 1991 ). Another adaptation that is most likely associated with heat pretreatment dependent adaptation was observed in the stress-regulatory transcription factors Msn2 and Msn4.…”

Section: Discussionmentioning

confidence: 99%

Physiological and Molecular Characterization of an Oxidative Stress-Resistant Saccharomyces cerevisiae Strain Obtained by Evolutionary Engineering

et al. 2022

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Oxidative stress is a major stress type observed in yeast bioprocesses, resulting in a decrease in yeast growth, viability, and productivity. Thus, robust yeast strains with increased resistance to oxidative stress are in highly demand by the industry. In addition, oxidative stress is also associated with aging and age-related complex conditions such as cancer and neurodegenerative diseases. Saccharomyces cerevisiae, as a model eukaryote, has been used to study these complex eukaryotic processes. However, the molecular mechanisms underlying oxidative stress responses and resistance are unclear. In this study, we have employed evolutionary engineering (also known as adaptive laboratory evolution – ALE) strategies to obtain an oxidative stress-resistant and genetically stable S. cerevisiae strain. Comparative physiological, transcriptomic, and genomic analyses of the evolved strain were then performed with respect to the reference strain. The results show that the oxidative stress-resistant evolved strain was also cross-resistant against other types of stressors, including heat, freeze-thaw, ethanol, cobalt, iron, and salt. It was also found to have higher levels of trehalose and glycogen production. Further, comparative transcriptomic analysis showed an upregulation of many genes associated with the stress response, transport, carbohydrate, lipid and cofactor metabolic processes, protein phosphorylation, cell wall organization, and biogenesis. Genes that were downregulated included those related to ribosome and RNA processing, nuclear transport, tRNA, and cell cycle. Whole genome re-sequencing analysis of the evolved strain identified mutations in genes related to the stress response, cell wall organization, carbohydrate metabolism/transport, which are in line with the physiological and transcriptomic results, and may give insight toward the complex molecular mechanisms of oxidative stress resistance.

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Heat shock factor-independent heat control of transcription of the CTT1 gene encoding the cytosolic catalase T of Saccharomyces cerevisiae

Cited by 135 publications

References 42 publications

Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature

Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature

Oxidative stress responses of the yeastSaccharomyces cerevisiae

Physiological and Molecular Characterization of an Oxidative Stress-Resistant Saccharomyces cerevisiae Strain Obtained by Evolutionary Engineering

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