Heat shock protein 27 and gross cystic disease fluid protein 15 play critical roles in molecular apocrine breast cancer

Liu, Xiaozhen; Feng, Changyun; Liu, Junjun; Zhao, Lin; Liu, Jian; Zhang, Wei; Liu, Ning; Niu, Yun

doi:10.1007/s13277-015-4712-4

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…We have previously stated that MABC was associated with a serious of increased risk of malignant breast cancer, including higher histological grade, tumor stage, and pTNM stage [11]. Our findings from this study supplemented the conclusion that MABC tumors metastasized earlier than nonMABC.…”

Section: Discussionsupporting

confidence: 86%

Early versus late distant metastasis and adjuvant chemotherapy alone versus both radiotherapy and chemotherapy in molecular apocrine breast cancer

et al. 2016

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As a new subtype of breast cancer, molecular apocrine breast cancer (MABC) is estrogen receptor (ER) and progesterone receptor (PR) negative expression, but androgen receptor (AR) positive expression. The prognostic significance and clinical biological behavior of MABC have remained unclear up to now. This study aimed to analysis the distant metastasis behavior and response to adjuvant radiotherapy and chemotherapy of MABC subgroup. The report showed that there were significant differences between early and late distant metastasizing tumors with respect to Ki67, epidermal growth factor receptor 2 (HER2) and vascular endothelial growth factor (VEGF) expressions by a retrospective analysis consisting of 410 invasive breast cancer patients, which included 205 MABC and 205 nonMABC cases. MABC subgroup metastasized earlier than nonMABC subgroup, and MABC showed a tendency for a higher metastasis rate in lung, liver and brain, but lower in bone. HER2-positive or VEGF-positive tumors were more inclined to develop bone metastasis within MABC subgroup. The survival rate was superior for patients undergone both adjuvant radiotherapy and chemotherapy than those undergone chemotherapy alone in nonMABC subgroup, but there was no significant difference in MABC subgroup. Our data suggested that MABC subgroup seemed to develop distant metastasis earlier than nonMABC subgroup, and patients with MABC indicated poor prognosis. This study might also provide a foundation for helping patients receive reasonable treatments according to molecular subtype.

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Section: Discussionsupporting

confidence: 86%

Early versus late distant metastasis and adjuvant chemotherapy alone versus both radiotherapy and chemotherapy in molecular apocrine breast cancer

et al. 2016

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“…ER, PR and HER2 are commonly used for diagnosing process and choosing appropriate treatment options for particular types of breast cancer. However, AR detected in 100% of ACs is an emerging potential target for accurate diagnosis and targeted treatment [6].…”

Section: Discussionmentioning

confidence: 99%

Apocrine breast carcinoma as an extremely rare breast cancer subtype – histopathological characteristics

Maksimiuk

Budzik

Sobiborowicz

et al. 2019

Nowotwory. Journal of Oncology

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Apocrine carcinoma (AC) is a distinctive and rare type of malignancy, counted for 0.3-4% of all breast cancer cases. It does not have a particular clinical or radiological features, although it is characterized by the apocrine morphology, estrogen receptor-negative and androgen receptor-positive profile. In the present study, among 1122 patients with breast cancer only 5 of them were diagnosed with apocrine carcinoma (0.4%). All patients were above 50 years old (51-63, mean: 57). Tumor size varied from 1.4 cm to 3.8 cm with a mean size of 2.4 cm, while mean size of all 1122 studied cases counted for 1.9 cm. Two tumors were classified as high-grade (G3), 2 as G2, and 1 as G1. Four tumors out of 5 did not affect lymph nodes (pN0 stage), whereas 1 was classified as pN2 with 9/19 regional lymph nodes affected. This observation was consistent with the whole studied group, in which pN0 stage made up the largest percentage. Presented results suggest that AC is less frequent in premenopausal patients. AC tends to present as invasive malignancy without nodal involvement and is usually characterized by relatively less aggressive biological behavior compared to other histological types of breast cancer. Due to the fact that AC is definitely a rare type of breast cancer, modern medicine has still limited treatment options to offer. Further research needs to be conducted in order to develop target therapies for this carcinoma.

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“… 33 – 35 With respect to cancer therapy, elevated Hsp27 levels in breast, ovarian, pancreatic, colon, and bladder cancers are associated with poor prognosis. 36 – 43 In addition, Hsp27 overexpression has been linked to resistance to chemotherapeutic agents in lung, prostate, breast, pancreas, and colon cancers. 44 – 52 …”

Section: Introductionmentioning

confidence: 99%

The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation

Boyd,

Majumder,

Stiban

et al. 2023

Cell Reports

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Heat shock protein 27 and gross cystic disease fluid protein 15 play critical roles in molecular apocrine breast cancer

Cited by 4 publications

References 33 publications

Early versus late distant metastasis and adjuvant chemotherapy alone versus both radiotherapy and chemotherapy in molecular apocrine breast cancer

Early versus late distant metastasis and adjuvant chemotherapy alone versus both radiotherapy and chemotherapy in molecular apocrine breast cancer

Apocrine breast carcinoma as an extremely rare breast cancer subtype – histopathological characteristics

The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation

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