Heat Shock Protein 70 Gene Polymorphisms in Sudden Sensorineural Hearing Loss

Abstract

Background: Heat shock proteins protect cells and tissues against different types of damage. Previous studies have revealed that the serum level of heat shock protein 70 (HSP70) increases in sudden sensorineural hearing loss (SSNHL) patients. We hypothesized that genetic variants of the HSP70 gene are associated with susceptibility to SSNHL. Methods: We conducted a case-control study with 160 SSNHL cases and 178 controls. Three tagging single nucleotide polymorphisms (SNPs) were selected. The genotypes were determined using TaqMan technology. Hardy-Weinberg equilibrium was tested for each SNP, and genetic effects were evaluated according to three inheritance modes. A haplotype analysis was also performed. Results: All three SNPs were in Hardy-Weinberg equilibrium. The CT genotype of rs2075800 exhibited an adjusted odds ratio of 0.59 (95% confidence interval 0.37–0.94; p = 0.027). The T allele of SNP rs2075800 was associated with SSNHL under the dominant model (p = 0.019; odds ratio 0.59). Haplotype analysis of the three SNPs demonstrated that the haplotype TGC (rs2075800/rs1043618/rs2763979) was statistically significant (p = 0.0137). Conclusions: These results suggest that HSP70 gene polymorphisms influence the susceptibility to the development of SSNHL in the Taiwanese population.

Association between Macrophage Migration Inhibitory Factor Gene Variation and Response to Glucocorticoid Treatment in Sudden Sensorineural Hearing Loss

“…According to the literature [Chien et al, 2012;Um et al, 2013], other genes might also have an impact on the presence of SSNHL, emphasizing that more studies are necessary to learn about the precise pathogenesis of SSNHL.…”

“…Although the etiology and pathogenesis of SSNHL are not known, various causes including viral infection, vascular disease and autoimmunity have been anticipated as the primary cause of the disease [Chien et al, 2012;Um et al, 2013]. However, it has so far been difficult to attribute one particular mechanism to individual cases.…”

“…Several pieces of evidence support the involvement of genetic factors in the presence of SSNHL as a complex multifactorial disease. The genetic markers attributed to SSNHL include prothrombin G20210A variant, factor V Leiden G1691A substitution and methylenetetrahydrofolate reductase (MTHFR) C677 polymorphisms [Chien et al, 2012]. Although the onset of disease is mostly in the elderly, it can occur at various ages [Weiss et al, 2014] and an incidence of 5-20 cases in 100,000 individuals each year has been estimated for the disease prevalence [Xenellis et al, 2006].…”

Genetic Polymorphisms and Susceptibility to Sudden Sensorineural Hearing Loss: A Systematic Review

“…Gross et al [Gross et al, 2008] found that the serum anti-HSP70 antibody and antiphospholipid antibody were significantly higher than the normal level in patients with SSNHL and the prognosis of SSNHL patients with positive anti-HSP70 antibody was better than that of negative patients, which indicated that HSP70 gene mutation may be associated with SSNHL. Subsequently, Chien et al [2012] described a significant association between one SNPs of HSP70 genes (rs2075800) and SSNHL. After haplotype analysis for three SNPs of HSP70 genes (rs2075800*, rs1043618, rs2763979), the haplotype TGC was found obviously different between healthy people and SSNHL patients.…”

“…In the past 20 years, a series of disease susceptibility genes, such as MTHFR, ITGB3, PRKCH, and HSP70, have been identified in SSNHL [Ballesteros et al, 2012;Chien et al, 2012;Shu et al, 2015;Uchida et al, 2011], indicating that the genetic factor may play a significant role in patients with SSNHL. Since most of these studies have a relatively small sample size and commonly use particular ethnic groups as research objects, the result is hard to extrapolate to the general population.…”