Heat Shock Protein 70 Gene Polymorphisms in Japanese Patients with Aspirin-Exacerbated Respiratory Disease

Kikuchi, Kenta; Abe, Shyuzo; Kodaira, Kazumi; Yukawa, Tatsuo; Hozawa, Soichiro; Mochizuki, Hiroyuki; Kurosawa, Motohiro

doi:10.2310/jim.0b013e3182857d6c

Cited by 13 publications

(16 citation statements)

References 53 publications

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“…Finally, AERD patients demonstrated a significant variation in eosinophil count by HSP SNP genotype, whereas the aspirin tolerant group did not 71 . While the molecular mechanisms of HSP70 variation and eosinophilia in AERD were not investigated in this study, the authors suggest that, as a possible mechanism, because the HSP-encoding genes are located within the MHC III region 72 , the HSP70 SNPs may be in linkage with other SNPs within this region, which is also adjacent to TNF and that could functionally contribute to this association 71 .…”

Section: Update On the Genetics Of Aerdmentioning

confidence: 86%

“…In patients with AERD, compared to the aspirin tolerant group, frequency of the HSPA1B -179CT/TT genotype was higher than that of the CC genotype, and the GG genotype of the HSPA1B -1267GG was also higher than that of the GA/AA genotype; furthermore, frequency of the HSPA1B -179C/1267A haplotype was also higher in the AERD group vs. ATA and was associated with a significantly increased risk of AERD (OR 3.154; 95 CI 1.916–5.193) 71 . Finally, AERD patients demonstrated a significant variation in eosinophil count by HSP SNP genotype, whereas the aspirin tolerant group did not 71 . While the molecular mechanisms of HSP70 variation and eosinophilia in AERD were not investigated in this study, the authors suggest that, as a possible mechanism, because the HSP-encoding genes are located within the MHC III region 72 , the HSP70 SNPs may be in linkage with other SNPs within this region, which is also adjacent to TNF and that could functionally contribute to this association 71 .…”

Section: Update On the Genetics Of Aerdmentioning

confidence: 94%

“…To investigate the hypothesis that HSP70 variation contributes to AERD susceptibility, a recent study evaluated the association of two candidate HSP70 polymorphisms- HSPA1B -179C>T and HSPA1B -1267A>G (rs6457452 and rs1061581) in 102 asthmatics with AERD, 300 ATA, and 100 normal healthy controls, all of Japanese descent 71 . In patients with AERD, compared to the aspirin tolerant group, frequency of the HSPA1B -179CT/TT genotype was higher than that of the CC genotype, and the GG genotype of the HSPA1B -1267GG was also higher than that of the GA/AA genotype; furthermore, frequency of the HSPA1B -179C/1267A haplotype was also higher in the AERD group vs. ATA and was associated with a significantly increased risk of AERD (OR 3.154; 95 CI 1.916–5.193) 71 . Finally, AERD patients demonstrated a significant variation in eosinophil count by HSP SNP genotype, whereas the aspirin tolerant group did not 71 .…”

Section: Update On the Genetics Of Aerdmentioning

confidence: 99%

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Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease

Dahlin

Weiss

2016

Immunology and Allergy Clinics of North America

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Section: Update On the Genetics Of Aerdmentioning

confidence: 86%

Section: Update On the Genetics Of Aerdmentioning

confidence: 94%

Section: Update On the Genetics Of Aerdmentioning

confidence: 99%

See 1 more Smart Citation

Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease

Dahlin

Weiss

2016

Immunology and Allergy Clinics of North America

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“…Functional N-acetyltransferase and CYP2C polymorphisms have recently been analyzed in relation to metamizole metabolic profile [85 && ]. Associations with NERD have been also reported for SNPs in formyl peptide receptor 2, a high-affinity ligand receptor for lipoxins [86], heat shock protein 70 [87], and members of the rat sarcoma viral (RAS) oncogene family [88].…”

Section: Miscellaneous Associationsmentioning

confidence: 89%

Genetic basis of hypersensitivity reactions to nonsteroidal anti-inflammatory drugs

Gómez

Perkins²,

García‐Martín³

et al. 2015

Current Opinion in Allergy &Amp; Clinical Immunology

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The full genetic and molecular basis of clinical entities induced by NSAIDs hypersensitivity has yet to be uncovered, and despite commendable efforts over recent years, no clinically proven genetic markers currently exist for these disorders. It is clear that we will continue to find more about these reactions in the coming years, concurrently with improvements in technology and experimental techniques, and a precise definition of different phenotypes.

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“…However, conflicting results have been reported [7,8], and other genetic determinants remain to be identified. We have reported some new genetic aspects in Japanese patients with AERD [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Solute Carrier Family 6 Member 12 Gene Polymorphisms in Japanese Patients with Aspirin-Exacerbated Respiratory Disease

Kurosawa¹,

Yukawa²

2015

J Allergy Ther

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Background: Betaine/gamma-aminobutyric acid (GABA) signaling pathway in the airway epithelium has been revealed to play a critical role in bronchial asthma. To elucidate any genetic influence of the GABAergic in aspirinexacerbated respiratory disease (AERD), we investigated the association of solute carrier family 6 (neurotransmitter transporter, betaine/GABA) member 12 (SLC6A12) gene in Japanese patients with AERD.Methods: DNA specimens were obtained from 103 AERD patients, 300 patients with aspirin-tolerant asthma (ATA) and 100 normal controls. Allelic discrimination assay for two single nucleotides polymorphisms in SLC6A12 gene (rs499368 and rs557881) was carried out. Results:The minor allele frequencies in SLC6A12 intron 2 A>T genotype (rs49936) were higher in AERD patients than in normal controls, and that in SLC6A12 exon 4 T>C genotype (rs557881) were higher in AERD patients than in ATA patients and normal controls. The frequencies of the combined TC/CC genotype group of SLC6A12 exon 4 T>C were higher than those of the TT genotype in AERD patients compared with those in ATA patients (P=0.021; odds ratio, 1.724; 95% confidence interval, 1.087-2.732). In male patients with AERD, frequencies of the TC/CC genotype group were higher than those of the TT genotype compared with male patients with ATA (P = 0.010; odds ratio, 3.177; 95% confidence interval, 1.311-7.699). Forced expiratory volume in one second (percentage predicted) in AERD patients with the TC/CC genotype group of the SLC6A12 exon 4 T>C gene was lower than that in the patients with the TT genotype (P=0.039). Conclusion:This is the first Japanese study to investigate the SLC6A12 intron 2 A>T and SLC6A12 exon 4 T>C genotype polymorphisms in patients with AERD. Our findings suggest that the association between SLC6A12 intron 2 A>T and exon 4 T>C gene sequence variations might be implicated in the development of AERD in a Japanese population.

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Heat Shock Protein 70 Gene Polymorphisms in Japanese Patients with Aspirin-Exacerbated Respiratory Disease

Abstract: Our findings first suggest that the association between HSPA1B-179C>T and 1267A>G gene sequence variations might be implicated in the development of AERD.

Cited by 13 publications

References 53 publications

Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease

Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease

Genetic basis of hypersensitivity reactions to nonsteroidal anti-inflammatory drugs

Solute Carrier Family 6 Member 12 Gene Polymorphisms in Japanese Patients with Aspirin-Exacerbated Respiratory Disease

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