Heat Shock Protein-70 Levels Are Associated With a State of Oxidative Damage in the Development of Bronchopulmonary Dysplasia

Hsiao, Chien‐Chou; Lee, Cheng‐Han; Yang, Rei‐Cheng; Chen, Jia-Yuh; Su, Tzu-Cheng; Chang, Yu-Jun; Lin, Ching‐Yuang; Tsai, Yu-Chen

doi:10.3389/fped.2021.616452

Cited by 8 publications

(11 citation statements)

References 29 publications

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“…8-OHdG is a biomarker of endogenous oxidative stress-related DNA damage ( 23 ). Hsiao et al ( 24 ) investigated the relationship between the 8-OHdG level in TA and BPD, reporting that the TA 8-OHdG level on postnatal day 28 was associated with BPD ( P < 0.05). In addition, 8-OHdG is considerably water soluble and is excreted in the urine without further metabolism ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study

Cui

Fu²

2022

Front. Pediatr.

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BackgroundThis study investigated whether 8-hydroxy-2’-deoxyguanosine (8-OHdG) and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in the urine could predict bronchopulmonary dysplasia (BPD) in preterm infants.MethodsThis prospective cohort study enrolled 165 preterm infants, of whom 70 developed BPD. We measured urinary 8-OHdG and NT-proBNP concentrations from day of life (DOL) 7 to 28. Then, we evaluated the prediction efficiency by receiver operating characteristic curves and assessed correlations between the two biomarkers. Finally, we identified the predictive risk factors for BPD by multivariable logistic regression.Results8-OHdG and NT-proBNP levels were significantly higher from DOL 7 to 28 in the BPD group than in the control group (P < 0.05). Additionally, the 8-OHdG level was positively correlated with the NT-proBNP level (r: 0.655–0.789, P < 0.001), and the 8-OHdG and NT-proBNP levels were positively correlated with mechanical ventilation duration and oxygen exposure time (r: 0.175–0.505, P < 0.05) from DOL 7 to 28. Furthermore, the 8-OHdG (DOL 14–28) and NT-proBNP (DOL 7–28) levels were significantly associated with BPD development (P < 0.05).ConclusionThe urine 8-OHdG concentrations from DOL 14 to 28 and NT-proBNP concentrations from DOL 7 to 28 may be practical non-invasive predictors of BPD development in preterm infants.

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Section: Discussionmentioning

confidence: 99%

Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study

Cui

Fu²

2022

Front. Pediatr.

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“…A decrease in the expression level of Hsp70 regardless of age is observed in such human diseases as pulmonary fibrosis, various types of "myopathies", cholesterol sphingolipids, sphingolipidoses, diabetes, obesity, etc. [133][134][135][136][137]. In these diseases, reduced levels of both HSF1 and various members of the Hsp70 family can be observed in adipose tissue, liver, muscle, neurons, and vascular beds of patients.…”

Section: Hsp70 As a Biomarker Of Pathological Processes And Diseasesmentioning

confidence: 99%

“…Therefore, the level of endogenous Hsp70 in cells is used, not only as a biomarker of various diseases but also to monitor the results of therapy for various human diseases [139,140]. In particular, Hsp70 levels have been used as a biomarker of prostate diseases and bronchopulmonary dysplasia (BPD) for targeted therapies [135,141]. Thus, it is known that Hsp70 levels are associated with a state of oxidative injury in the development of BPD [135].…”

Section: Hsp70 As a Biomarker Of Pathological Processes And Diseasesmentioning

confidence: 99%

“…In particular, Hsp70 levels have been used as a biomarker of prostate diseases and bronchopulmonary dysplasia (BPD) for targeted therapies [135,141]. Thus, it is known that Hsp70 levels are associated with a state of oxidative injury in the development of BPD [135]. Significant changes in Hsp70 levels in neuronal tissues have been reported in normal aging as well as in patients with neurodegenerative diseases accompanied by the formation of protein aggregates, including Alzheimer disease (AD), Parkinsonism, and amyotrophic lateral scle- and exogenous recHsp70 predominantly play an anti-inflammatory role, while membrane-bound Hsp70 may play a pro-inflammatory role.…”

Section: Hsp70 As a Biomarker Of Pathological Processes And Diseasesmentioning

confidence: 99%

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The Role of Hsp70 in Adaptation to Adverse Conditions and Its Possible Medical Application

Evgen’ev¹,

Onikienko²,

Chuvakova³

et al. 2023

Front. Biosci. (Landmark Ed)

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In the present era of global warming and dramatically increased environmental pollution posing a threat to animal life, the understanding and manipulation of organisms' resources of stress tolerance is apparently a question of survival. Heat stress and other forms of stressful factors induce a highly organized response of organisms at the cellular level where heat shock proteins (Hsps) and in particular Hsp70 family of chaperones are among the major players in the protection from the environmental challenge. The present review article summarizes the peculiarities of the Hsp70 family of proteins protective functions being a result of many millions of years of adaptive evolution. It discusses the molecular structure and specific details of hsp70 gene regulation in various organisms, living in diverse climatic zones, with a special emphasis on the protective role of Hsp70 in adverse conditions of the environment. The review discusses the molecular mechanisms underlying Hsp70-specific properties that emerged in the course of adaptation to harsh environmental conditions. This review also includes the data on the anti-inflammatory role of Hsp70 and the involvement of endogenous and recombinant Hsp70 (recHsp70) in proteostatic machinery in various pathologies including neurodegenerative ones such as Alzheimer's and Parkinson's diseases in rodent model organisms and humans in vivo and in vitro. Specifically, the role of Hsp70 as an indicator of disease type and severity and the use of recHsp70 in several pathologies are discussed. The review discusses different roles exhibited by Hsp70 in various diseases including the dual and sometimes antagonistic role of this chaperone in various forms of cancer and viral infection including the SARS-Cov-2 case. Since Hsp70 apparently plays an important role in many diseases and pathologies and has significant therapeutic potential there is a dire need to develop cheap recombinant Hsp70 production and further investigate the interaction of externally supplied and endogenous Hsp70 in chaperonotherapy.

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“…Our previous study showed that LA tissue exhibited greater levels of oxidative stress and atrial fibrosis compared to RA in reduced ejection fraction HF rats measured by echocardiography [ 36 ]. The RA has a greater expression of heat shock protein 70, which may result in a cytoprotective effect against oxidative stress and, consequently, lower levels of fibrogenesis [ 79 , 80 ]. Hepcidin is an antimicrobial protein that controls iron metabolism in mammals [ 141 ].…”

Section: Mechanisms Contributing To the Regional Diversities Of Atrial Fibrogenesismentioning

confidence: 99%

Regional Diversities in Fibrogenesis Weighed as a Key Determinant for Atrial Arrhythmogenesis

et al. 2021

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Atrial fibrosis plays a key role in atrial myopathy, resulting in the genesis of atrial fibrillation (AF). The abnormal distribution of fibrotic tissue, electrical coupling, paracrine interactions, and biomechanical–electrical interactions have all been suggested as causes of fibrosis-related arrhythmogenesis. Moreover, the regional difference in fibrogenesis, specifically the left atrium (LA) exhibiting a higher arrhythmogenesis and level of fibrosis than the right atrium (RA) in AF, is a key contributor to atrial arrhythmogenesis. LA fibroblasts have greater profibrotic cellular activities than RA fibroblasts, but knowledge about the regional diversity of atrial regional fibrogenesis remains limited. This article provides a comprehensive review of research findings on the association between fibrogenesis and arrhythmogenesis from laboratory to clinical evidence and updates the current understanding of the potential mechanism underlying the difference in fibrogenesis between the LA and RA.

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Heat Shock Protein-70 Levels Are Associated With a State of Oxidative Damage in the Development of Bronchopulmonary Dysplasia

Cited by 8 publications

References 29 publications

Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study

Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study

The Role of Hsp70 in Adaptation to Adverse Conditions and Its Possible Medical Application

Regional Diversities in Fibrogenesis Weighed as a Key Determinant for Atrial Arrhythmogenesis

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