Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy

Vargas–Roig, Laura M.; Gago, Francisco E.; Tello, Olga; Aznar, Juan C.; Ciocca, Daniel R.

doi:10.1002/(sici)1097-0215(19981023)79:5<468::aid-ijc4>3.0.co;2-z

Cited by 260 publications

(153 citation statements)

References 12 publications

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“…Figure 4b shows the colocalization of the two proteins in untreated MCF-7 cells. In a previous study, we have shown that Hsp27 protein is located mainly in the cytoplasm of the tumor cells, but that under stress conditions Hsp27 can be translocated to the nucleus (Vargas-Roig et al 1998). As expected, in non-stressed MCF-7 cells, Hsp27 was mainly found in the cytoplasm while PTEN was located in the cytoplasm and in the nuclei of the tumor cells.…”

Section: Resultssupporting

confidence: 70%

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Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN

Cayado-Gutiérrez

Moncalero

Rosales

et al. 2013

Cell Stress and Chaperones

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Section: Resultssupporting

confidence: 70%

“…Hsp27 (HSPB1) is usually over-expressed in breast cancers affecting the disease outcome and the sensitivity of tumors to chemotherapy and radiotherapy (Vargas-Roig et al 1998;Ciocca and Calderwood 2005;Ciocca et al 2010). Hsp27 is a molecular chaperone that can interact with other proteins.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN

Cayado-Gutiérrez

Moncalero

Rosales

et al. 2013

Cell Stress and Chaperones

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“…In addition to HSP90 inhibitors, many cytotoxic chemotherapeutic agents also potently activate Hsf1 and the HSR (43)(44)(45)(46). Interestingly, some cytotoxic chemotherapeutic agents are also known to promote osteoclast formation (13).…”

Section: Ethanol and Chemotherapeutic Agents Enhance Osteoclastmentioning

confidence: 99%

Molecular Stress-inducing Compounds Increase Osteoclast Formation in a Heat Shock Factor 1 Protein-dependent Manner

Chai

Kouspou

Lang

et al. 2014

Journal of Biological Chemistry

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Background: HSP90 inhibitors increase osteoclast formation and bone loss. Results: Altered Hsf1 activity impacts the ability of stress-inducing compounds to modulate osteoclast formation. Conclusion: Hsf1 plays an important role in stress-associated osteoclast formation, potentially via MITF. Significance: We identified a novel pathway whereby agents inducing stress can enhance osteoclast formation.

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“…Elevated expression of Hsp70 and Hsp90 in tumour cells has been detected in several cases [6,7]. In breast cancer, over-expression of Hsp70 has been correlated with metastasis and poor prognosis [5,8,20]. At least two factors contribute to this phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Mathematical modeling of heat shock protein synthesis in response to temperature change

Szymańska

Żylicz

2009

Journal of Theoretical Biology

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To cite this version:Zuzanna Szymańska, Maciej Zylicz. Mathematical modeling of heat shock protein synthesis in response to temperature change. Journal of Theoretical Biology, Elsevier, 2009, 259 (3) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A c c e p t e d m a n u s c r i p t AbstractOne of the most important questions in cell biology is how cells cope with rapid changes in their environment. The range of common molecular responses includes a dramatic change in the pattern of gene expression and the elevated synthesis of so called heat shock (or stress) proteins (HSPs). Induction of HSPs increases cell survival under stress conditions [9]. In this paper we propose a mathematical model of heat shock protein (HSP) synthesis induced by an external temperature stimulus. Our model consists of a system of nine nonlinear ordinary differential equations describing the temporal evolution of the key variables involved in the regulation of HSP synthesis. Computational simulations of our model are carried out for different external temperature stimuli. We compare our model predictions with experimental data for three different cases -one corresponding to heat shock, the second corresponding to slow heating conditions and the third corresponding to a short heat shock (lasting about 40 minutes). We also present our model predictions for heat shocks carried out up to different final temperatures and finally we present a new hypothesis concerning the molecular response to stress that explains some phenomena observed in experiments.

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Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy

Cited by 260 publications

References 12 publications

Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN

Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN

Molecular Stress-inducing Compounds Increase Osteoclast Formation in a Heat Shock Factor 1 Protein-dependent Manner

Mathematical modeling of heat shock protein synthesis in response to temperature change

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