“…Moreover, increased expression of Grp78 gene after fertilization also indicated its major role as a molecular chaperone during developmental days in fish. Developmental regulation of many Hsps genes such as Hsp90α, Hsp90β, and Hsp47 was observed in zebrafish previously (Basu et al 2002). Constitutive expression of Grp78 gene in several important tissues emphasized its importance in regulating ER Fig.…”
“…Moreover, increased expression of Grp78 gene after fertilization also indicated its major role as a molecular chaperone during developmental days in fish. Developmental regulation of many Hsps genes such as Hsp90α, Hsp90β, and Hsp47 was observed in zebrafish previously (Basu et al 2002). Constitutive expression of Grp78 gene in several important tissues emphasized its importance in regulating ER Fig.…”
“…Heat-shock proteins are well known to protect organisms from the detrimental effects by stressors [27,28]. However, synthesis of heat shock proteins is energy demanding [29], and the synthetic substrate is at the expense of other cellular proteins [30].…”
“…It is well known that the releasing of heat-shock proteins is to protect organisms from the detrimental effects by stressors [34,35]. However, synthesis of heat shock proteins is energy demanding [36], and the synthetic substrate is at the expense of other cellular proteins [37].…”
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