Heat Shock Protein HSP70 in Oxidative Stress in Apnea Patients

Мадаева, Ирина; Курашова, Н. А.; Семенова, Н. В.; Ухинов, Э. Б.; Колесников, С. И.; Колесникова, Л. И.

doi:10.1007/s10517-020-04957-9

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…Cao et al have demonstrated that in vitro exposure of neonatal rat pulmonary microvascular endothelial cells (PMVECs) to hypoxia upregulated HSP70 expression levels compared to cells maintained under normal oxygen conditions 43 . In addition, Madaeva et al demonstrated a direct relationship between oxidative stress levels and HSP70 expression in apneic patients 44 . Hypoxia also induces HSP70 expression in many organs, including the heart, liver, and intestine 45 – 49 .…”

Section: Discussionmentioning

confidence: 98%

Forensic application of epidermal expression of HSP27 and HSP70 for the determination of wound vitality in human compressed neck skin

Zhang

Ishida

Ishigami

et al. 2023

Sci Rep

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Estimating the age and vitality of human skin wounds is essential in forensic practice, and the use of immunohistochemical parameters in this regard remains a challenge. Heat shock proteins (HSPs) are evolutionarily conserved universal proteins that protect biological systems from various types of stress. However, its importance in forensic pathology for determining wound activation in neck compression skin remains unclear. The expression of HSP27 and HSP70 in neck skin samples was immunohistochemically examined to understand its forensic applicability in determining wound vitality. Skin samples were obtained from 45 cases of neck compression (hanging, 32 cases; strangulation, 10 cases; manual strangulation, 2 cases; other, 1 case) during forensic autopsies; intact skin from the same individual was used as a control. HSP27 expression was detected in 17.4% of keratinocytes in the intact skin samples. In the compressed region, the frequency of HSP27 expression in keratinocytes was 75.8%, which was significantly higher than that in intact skin. Similarly, HSP70 expression was 24.8% in intact skin samples and 81.9% in compressed skin samples, significantly higher in compressed skin than in intact skin samples. This increase in case compression cases may be due to the cell defence role of HSPs. From a forensic pathology perspective, the immunohistochemical examination of HSP27 and HSP70 expression in neck skin could be considered a valuable marker for diagnosing traces of antemortem compression.

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Section: Discussionmentioning

confidence: 98%

Forensic application of epidermal expression of HSP27 and HSP70 for the determination of wound vitality in human compressed neck skin

Zhang

Ishida

Ishigami

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Cao et al have demonstrated that in vitro exposure of neonatal rat pulmonary microvascular endothelial cells (PMVECs) to hypoxia upregulated HSP70 expression levels compared to cells maintained under normal oxygen conditions (54). In addition, Madaeva et al demonstrated a direct relationship between oxidative stress levels and HSP70 expression in apneic patients (55). Hypoxia also induced HSP70 expression in many organs, including heart, liver, and intestine (56-60).…”

Section: Discussionmentioning

confidence: 99%

Forensic application of epidermal expression of HSP27 and HSP70 for the determination of wound vitality in human compressed neck skin

Zhang

Ishida

Ishigami

et al. 2022

Preprint

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Estimating the age and vitality of human skin wounds is essential for forensic practice, and the use of immunohistochemical parameters for the same remains a challenge. Heat shock proteins (HSPs) are evolutionarily conserved, universal systems that protect the biological system from various types of stress. However, its importance in forensic pathology in determining wound activation of neck compression skin remains unclear. To understand the forensic applicability in determining wound vitality, the expression of HSP27 and HSP70 in neck skin samples was examined immunohistochemically. Skin samples were obtained from 45 cases of neck compression (hanging, 32 cases; strangulation, 10 cases; manual strangulation, two cases; other, one case) during forensic autopsies; intact skin from the same individual was used as a control. HSP27 expression was detected in 17.4% of keratinocytes in intact skin samples. In the compressed region, the frequency of HSP27 expression in keratinocytes was 75.8%, which was significantly higher than that in intact skin. Similarly, the frequency of HSP70 expression was 24.8% in intact skin and 81.9% in compressed skin, which was significantly higher in compressed skin than in intact skin. This increase in case compression cases may be due to the cell defense role of HSPs. From a forensic pathology perspective, immunohistochemical examination of HSP27 and HSP70 expression in neck skin can be seen as a valuable marker for diagnosing traces of prenatal compression.

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“…At present, many studies have proved that many HSPs are closely related to oxidative stress. For example, the expression of HSP70 is directly related to the intensity of oxidative stress in patients with apnea [180] . The overexpression of HSP22 can reduce the rate of oxidative phosphorylation and high superoxide production induced by mitochondrial hypoxia, thus playing a protective role on the oxidative stress caused by cardiac ischemia [181] .…”

Section: Hspsmentioning

confidence: 99%

Lignans are the main active components of Schisandrae Chinensis Fructus for liver disease treatment: a review

Fu,

Dai,

et al. 2024

Food Science and Human Wellness

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As a traditional Chinese herbal medicine, Schisandrae Chinensis Fructus (SC) has been used in medicine and food industry due to its health care and therapeutic effects. Over the past 20 years, the use of SC and its active ingredient lignans in the prevention and treatment of liver diseases has been increasing, and their hepatoprotective effects has increased the interest of the public and academia. Therefore, in the present work, we first determined the effectiveness of SC in the treatment of liver diseases such as metabolic associated fatty liver disease, alcoholic liver disease, cholestatic liver disease and acute liver injury. Subsequently, the pharmacological effects and molecular mechanisms of lignans, the active components of SC, for liver disease treatment were comprehensively summarized for the first time. The results showed that the lignans in SC could achieve hepatoprotective effects by regulating lipid metabolism, anti-fibrosis, anti-inflammation, anti-oxidation, anti-tumor and regulating bile acid metabolism. The mechanism mainly involved adenosine 5'-monophosphate-activated protein kinase, endoplasmic reticulum stress, sterol regulatory element binding protein 1c, autophagy, transforming growth factor-β, mitogen-activated protein kinase, microRNA, nuclear factor kappa-B, nuclear factor erythroid-2-related factor 2, heat shock proteins and pregnane X receptor signaling pathways. These results can lay a scientific foundation for the development of hepatoprotective drugs or functional foods from SC/lignans.

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Heat Shock Protein HSP70 in Oxidative Stress in Apnea Patients

Cited by 7 publications

References 11 publications

Forensic application of epidermal expression of HSP27 and HSP70 for the determination of wound vitality in human compressed neck skin

Forensic application of epidermal expression of HSP27 and HSP70 for the determination of wound vitality in human compressed neck skin

Forensic application of epidermal expression of HSP27 and HSP70 for the determination of wound vitality in human compressed neck skin

Lignans are the main active components of Schisandrae Chinensis Fructus for liver disease treatment: a review

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