Heat shock proteins 60 and 70 expression of cutaneous lichen planus: comparison with normal skin and psoriasis vulgaris*

Abstract

Significantly altered levels of HSP proteins were found in cutaneous LP lesions in comparison with normal skin and psoriasis, suggesting the role of HSPs in the pathogenesis of LP.

Expression of the heat shock protein-27 in the adult human scalp skin and hair follicle: Hair cycle–dependent changes

“…2,11,20 Moreover, the role of HSP27 in the keratinocyte cell growth and renewal is supported by the finding of altered expression of this protein in lichen planus, systemic lupus erythematosus, atopic dermatitis, and graft-versus-host disease. 21,22 The strong expression of HSP27 during anagen/ early catagen and its weak reactivity in the late catagen/telogen agrees with findings in the murine HF model 15 and suggests the involvement of HSP27 in HF cellular cycling events. 23 In murine HFs, there is an increased expression of HSP27 in the epithelial compartment during anagen VI and early catagen, and decreased expression during telogen.…”

Aberrant Expression and Secretion of Heat Shock Protein 90 in Patients with Bullous Pemphigoid

“…Cells of both epidermis and dermis constitutively express different Hsps, including Hsp90 [16], and some of them have been described to be upregulated in a variety of inflammatory skin conditions including UV-, hyperthermia- and heavy metal-provoked skin reactions [17]–[19], psoriasis [20], atopic dermatitis [21], systemic lupus erythematosus [22], lichen planus [23], Behçet’s disease [24], and graft-versus-host disease [25]. Except for mucous membrane pemphigoid, in which Hsp90 was found to be highly upregulated in the conjunctiva of affected patients [26], data on expression levels of this chaperone in autoimmune bullous skin diseases are lacking.…”

Heat shock protein 60: regulatory role on innate immune cells

“…It has become evident that extracellular HSPs act as potent intercellular signalling molecules that serve as danger signals to the innate immune system when expressed on or released by autologous cells, influencing a wide range of immune reactions [13,14]. In particular, immune responses directed against members of the HSP60, HSP70 and HSP90 families are implicated to contribute to the pathogenesis of a variety of tissue-specific autoimmune disorders, vascular diseases and inflammatory skin disorders [12,[15][16][17][18]. For members of the HSP60 family, which have been described as immunodominant molecules in various diseases, a potential immunoregulatory role in the development of tissuespecific autoimmune disorders such as rheumatoid arthritis and type 1 diabetes and in vascular diseases like arteriosclerosis has been suggested [19][20][21][22][23].…”