Heat Shock Proteins and Cardiovascular Disease

Zilaee, Marzie; Ferns, Gordon A.; Ghayour‐Mobarhan, Majid

doi:10.1016/b978-0-12-800263-6.00002-1

Cited by 27 publications

(13 citation statements)

References 236 publications

(282 reference statements)

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“…ERMs also act as a scaffold and interact with Rho-GDI-1, G␣ 13 protein, and FAK, which may modulate RhoA signaling and AJ function (26). Members of the stress-inducible small heat shock protein family (HSP) also regulate actin polymerization in vitro (164). Interestingly, depletion of moesin but not radixin markedly attenuated thrombin-induced increases in endothelial barrier permeability, cytoskeletal rearrangements, paracellular gap formation, and accumulation of phospho-myosin light chain.…”

Section: Endothelial Scaffoldsmentioning

confidence: 99%

Novel regulators of endothelial barrier function

Mehta

Ravindran

Kuebler

2014

American Journal of Physiology-Lung Cellular and Molecular Phys

109

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Endothelial barrier function is an essential and tightly regulated process that ensures proper compartmentalization of the vascular and interstitial space, while allowing for the diffusive exchange of small molecules and the controlled trafficking of macromolecules and immune cells. Failure to control endothelial barrier integrity results in excessive leakage of fluid and proteins from the vasculature that can rapidly become fatal in scenarios such as sepsis or the acute respiratory distress syndrome. Here, we highlight recent advances in our understanding on the regulation of endothelial permeability, with a specific focus on the endothelial glycocalyx and endothelial scaffolds, regulatory intracellular signaling cascades, as well as triggers and mediators that either disrupt or enhance endothelial barrier integrity, and provide our perspective as to areas of seeming controversy and knowledge gaps, respectively.

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Section: Endothelial Scaffoldsmentioning

confidence: 99%

Novel regulators of endothelial barrier function

Mehta

Ravindran

Kuebler

2014

American Journal of Physiology-Lung Cellular and Molecular Phys

109

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“…160 Heat shock proteins (HSPs) are molecular chaperones which are essential for cell survival. 161 Hypoxia was reported to markedly increase the expression of several HSPs in human saphenous vein and the internal mammary artery from patients undergoing coronary artery bypass surgery. A 6 h period of oxygen deprivation resulted in elevated levels of HSP60, and HSP72 and of HSP73 in the saphenous vein.…”

Section: Ex Vivo Human Studiesmentioning

confidence: 99%

Hypoxia in Atherogenesis

Ferns

Heikal

2016

Angiology

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The anoxemia theory proposes that an imbalance between the demand for, and supply of, oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now substantial evidence that there are regions within the atherosclerotic plaque in which profound hypoxia exists; this may fundamentally change the function, metabolism and responses of many of the cell types found within the developing plaque and whether the plaque will evolve into a stable or unstable phenotype. Hypoxia is characterized in molecular terms by the stabilization of hypoxia inducible factor (HIF)-1α; a subunit of the hetero-dimeric nuclear transcriptional factor HIF-1; a master regulator of oxygen homeostasis.HIF-1 expression is localized to perivascular tissues, inflammatory macrophages and smooth muscle cells adjacent to the necrotic core of atherosclerotic lesions, and regulates several genes that are important to vascular function including vascular endothelial growth factor (VEGF), nitric oxide synthase (NOS), endothelin-1 and erythropoietin (EPO). This review summarizes the effects of hypoxia on the functions of cells involved in atherogenesis, and the evidence for its potential importance from experimental models and clinical studies.

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“…Niezwykle interesująca wydaje się też idea, mogąca mieć zastosowanie w przyszłości u ludzi, by poprzez terapeutyczne wywoływanie stanu tolerancji na autoantygeny HSP hamować proces aterogenezy (tzw. szczepionka na miażdżycę) [52][53][54][55][56][57][58].…”

Section: Aspekty Kardiologiczneunclassified

Selected novel aspects in pathogenesis of lupus erythematosus – interdisciplinary view

Kalińska-Bienias¹,

Foroncewicz²,

Bienias³

et al. 2016

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StreSzczenieToczeń rumieniowaty to choroba autoimmunizacyjna charakteryzują-ca się złożonymi zaburzeniami immunologicznymi, dotyczącymi odpowiedzi humoralnej i komórkowej. Pomimo intensywnie prowadzonych badań wiele procesów patologicznych dotyczących tej choroby jest wciąż niewyjaśnionych. W badaniach interdyscyplinarnych nad etiopatogenezą tocznia rumieniowatego i jego powikłań szczególne zainteresowanie w ostatnim czasie dotyczy białek szoku termicznego, przeciwciał skierowanych przeciwko tym białkom oraz galektyny 3. Zagadnienia te są intensywnie badane nie tylko przez dermatologów i reumatologów, lecz także kardiologów (w aspekcie powikłań sercowo-naczyniowych) i nefrologów (w aspekcie toczniowej choroby nerek). W pracy przedstawiono aktualny stan wiedzy dermatologicznej, nefrologicznej i kardiologicznej na ten temat. AbStrActLupus erythematosus is an autoimmune disease characterized by complex immune disturbances concerning humoral and cell-mediated immune responses. Despite intensive research, many pathological processes regarding this disorder remain unexplained. During interdisciplinary investigations on the etiology of lupus and its complications special interest has recently been referred to heat-shock proteins, antibodies directed against such proteins and galectin-3. These issues are extensively studied not only by dermatologists and rheumatologists, but also by cardiologists (in terms of cardiovascular complications) and nephrologists (in terms of lupus nephritis). This study presents the current state of dermatological, nephrological and cardiological knowledge on this topic. toczeń rumieniowaty skórny, toczeń rumieniowaty układowy, białka szoku termicznego, galektyna 3, patogeneza.

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Heat Shock Proteins and Cardiovascular Disease

Cited by 27 publications

References 236 publications

Novel regulators of endothelial barrier function

Novel regulators of endothelial barrier function

Hypoxia in Atherogenesis

Selected novel aspects in pathogenesis of lupus erythematosus – interdisciplinary view

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