2022
DOI: 10.3389/fimmu.2022.947789
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Heat shock proteins and viral infection

Abstract: Heat shock proteins (HSPs) are a kind of proteins which mostly found in bacterial, plant and animal cells, in which they are involved in the monitoring and regulation of cellular life activities. HSPs protect other proteins under environmental and cellular stress by regulating protein folding and supporting the correctly folded structure of proteins as chaperones. During viral infection, some HSPs can have an antiviral effect by inhibiting viral proliferation through interaction and activating immune pathways … Show more

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Cited by 37 publications
(41 citation statements)
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“…Thus, on the one hand, the increased content of endogenous Hsp70 on the cell membrane observed in many forms of cancer can hinder successful anti-cancer therapy, on the other hand, administration of recHsp70 in Margulis' laboratory and several other groups had a significant therapeutic effect both in vitro when used on various cancer cells and in vivo in pilot experiments [173][174][175][176], where injections of recombinant human Hsp70 were made directly into tumors of volunteers [176]. In their study of melanoma cells, this group showed that injection of recombinant Hsp70 triggers extracellular transport of its endogenous homolog in soluble form and as EVs (extracellular vesicles), that penetrate neighboring cells, resulting in a dramatic reduction in the growth rate of cancer cells [177]. In another study on carcinoma cases, the patients were injected with dendritic cells containing hsp70 mRNA induced by electroporation, and a positive effect was also observed in several patients [178].…”
Section: The Use Of Recombinant Hsp70 In Model Experiments and Clinic...mentioning
confidence: 99%
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“…Thus, on the one hand, the increased content of endogenous Hsp70 on the cell membrane observed in many forms of cancer can hinder successful anti-cancer therapy, on the other hand, administration of recHsp70 in Margulis' laboratory and several other groups had a significant therapeutic effect both in vitro when used on various cancer cells and in vivo in pilot experiments [173][174][175][176], where injections of recombinant human Hsp70 were made directly into tumors of volunteers [176]. In their study of melanoma cells, this group showed that injection of recombinant Hsp70 triggers extracellular transport of its endogenous homolog in soluble form and as EVs (extracellular vesicles), that penetrate neighboring cells, resulting in a dramatic reduction in the growth rate of cancer cells [177]. In another study on carcinoma cases, the patients were injected with dendritic cells containing hsp70 mRNA induced by electroporation, and a positive effect was also observed in several patients [178].…”
Section: The Use Of Recombinant Hsp70 In Model Experiments and Clinic...mentioning
confidence: 99%
“…Intensive research on the role of endogenous and recombinant Hsp70 in aging, as well as in a variety of diseases and pathologies in model animals and humans resulted in the description of a variety of factors and signaling pathways with which Hsp70 interacts in carrying out its protective functions. Numerous excellent reviews are describing the functions of Hsp70 under normal conditions and after stress [5,24,126,141,144,177]. Therefore, in this section, we will only briefly discuss the known properties of Hsp70 that can be used in the therapy of some human diseases.…”
Section: Molecular Mechanisms Underlying Protective Effects Of Hsp70 ...mentioning
confidence: 99%
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“… 14 Heat shock proteins (HSP) such as HSP 40, HSP 70, and HSP 90 have been extensively studied in this area, and they are involved in various stages of viral infection. 15 HSPs play a vital role in the lifecycle of proteins, including protein folding and refolding, transport, degradation, assembly, activity regulation, and translocation, as well as the depolymerisation of protein aggregates. 15 The interaction of viral proteins with HSPs can change the apoptosis pathways in which they are involved, making it easier to activate caspase cascades and induce apoptosis to release viruses while evading the immune system.…”
Section: Neurodegenerative Mechanisms Associated With Viral Infectionmentioning
confidence: 99%
“…The heat shock proteins (Hsps), which not only facilitate protein folding, assembly, transportation, but also assist misfolded proteins to refold into functional states and degrade impaired proteins, are crucial in maintaining cellular homeostasis (Hu, Yang et al, 2022). Based on these salient characteristics, Hsps, including Hsp70 family, are often usurped by viruses to benefit their own survival (Zhang & Yu, 2022). Hsp70 family is highly conserved upon sequence and structure.…”
Section: Introductionmentioning
confidence: 99%