Heat Shock Proteins: Endogenous Modulators of Ferroptosis

Kang, Rui; Tang, Daolin

doi:10.1007/978-3-030-26780-3_4

Cited by 5 publications

(2 citation statements)

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“…Heat shock proteins (Hsps) are stress-responsive molecular chaperones, which uphold proper protein folding in response to external and internal stresses [6]. Based on their molecular size, these proteins can be classified into six subfamilies, i.e., Hsp100, Hsp90, Hsp70, Hsp60, Hsp40 and Hsp20 [7]. Among these, Hsp100 family is also known as ClpB due its capacity for promoting proteolysis of casein (caseinolytic protease B proteins).…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic and expression dynamics of tomato ClpB/Hsp100 gene under heat stress

et al. 2021

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Heat shock proteins (Hsps) are stress-responsive molecular chaperones, which uphold proper protein folding in response to external and internal stresses. The Hsp100 gene family plays a substantial role in thermos-tolerance of plants. This study investigated evolutionary relationship and expression of ClpB/Hsp100 gene family in tomato under heat stress. Six SlHsp100 genes were identified using bioinformatics tools. In silico sub-cellular localization indicated that of these 6 ClpB/Hsp100 members, 4 are found in chloroplast, 1 in mitochondria and 1 in the cytoplasm. For evolutionary study, 36 SlHsp100 genes were included in the phylogenetic tree showing a hierarchical clustering shared by the members of the kingdoms Plantae, Archaea, Chromista, Fungi and Bacteria. A total 4 pairs of orthologous and 5 pairs of paralogous genes were identified. Functional divergence between different Hsp100 clusters showed considerable functional homology. Thermo-tolerance measured in terms of cell viability, cell membrane stability and pollen viability indicated that it was paralleled by thermal resistance of Hsps. Reverse transcriptase polymerase chain reaction was used to analyze gene expression in leaves of five-week-old tomato seedlings following exposure to heat stress (45°C) and control (25°C). Chloroplastic LeHSP110/ClpB gene was upregulated in all tomato genotypes after exposure to heat stress highlighting the crucial role of this gene family in acquired thermo-tolerance.

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Section: Introductionmentioning

confidence: 99%

Phylogenetic and expression dynamics of tomato ClpB/Hsp100 gene under heat stress

et al. 2021

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“…C-Myc regulates cysteine dioxygenase type 1 (CDO1) [ 69 ], the inhibition of which restores the activity of GPx4 [ 70 ]. Anti-apoptotic protein HSP-70 is involved in rendering resistance to multiple types of regulated cell death [ 71 , 72 ] and was shown to sustain damage from increased levels of ROS and lipid peroxides [ 73 ]. Enzymatic oxidation of cytochrome c, on the other hand, promotes ferroptosis caused i.a.…”

Section: Gallium Salts Complexes and Nanoparticlesmentioning

confidence: 99%

Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings

Bartos

Sikora

2023

IJMS

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Ferroptosis was first reported as a separate modality of regulated cell death in 2008 and distinguished under its current name in 2012 after it was first induced with erastin. In the following decade, multiple other chemical agents were researched for their pro- or anti-ferroptotic properties. Complex organic structures with numerous aromatic moieties make up the majority of this list. This review fills a more overlooked niche by gathering, outlining and setting out conclusions regarding less prominent cases of ferroptosis induced by bioinorganic compounds and reported on within the last few years. The article contains a short summary of the application of bioinorganic chemicals based on gallium, several chalcogens, transition metals and elements known as human toxicants used for the purpose of evoking ferroptotic cell death in vitro or in vivo. These are used in the form of free ions, salts, chelates, gaseous and solid oxides or nanoparticles. Knowledge of how exactly these modulators promote or inhibit ferroptosis could be beneficial in the context of future therapies aimed against cancer or neurodegenerative diseases, respectively.

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