Heat-Shock Proteins in Diagnosis and Treatment: An Overview of Different Biochemical and Immunological Functions

Milani, Alireza; Basirnejad, Marzieh; Bolhassani, Azam

doi:10.2217/imt-2018-0105

Cited by 47 publications

(37 citation statements)

References 229 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The third new result was that HSP60 was a novel antiviral protein against PRRSV replication (Figure ). It is known that HSP60 plays a significant role in chaperone activity and protein folding, and previous reports about the relationship between HSP60 and virus replication have shown that HSP60 could act as an important factor for viral replication . Here, we found that overexpression of HSP60 could inhibit PRRSV replication in MARC‐145 cells, and knockdown of HSP60 could promote PRRSV replication (Figure ), which indicated that HSP60 was an antiviral protein against PRRSV replication.…”

Section: Discussionsupporting

confidence: 60%

miR‐382‐5p promotes porcine reproductive and respiratory syndrome virus (PRRSV) replication by negatively regulating the induction of type I interferon

et al. 2020

View full text Add to dashboard Cite

Previous studies have indicated that inhibition of type I interferon production may be an important reason for porcine reproductive and respiratory syndrome virus (PRRSV) to achieve immune escape, revealing the mechanism of inhibiting the production of type I interferon will help design novel strategies for controlling PRRS. Here, we found that PRRSV infection upregulated the expression of miR-382-5p, which in turn inhibited polyI:C-induced the production of type I interferon by targeting heat shock protein 60 (HSP60), thus facilitating PRRSV replication in MARC-145 cells. Furthermore, we found that HSP60 could interact with mitochondrial antiviral signaling protein (MAVS), an important signal transduction protein for inducing production of type I interferon, and promote polyI:C-mediated the production of type I interferon in a MAVS-dependent manner. Finally, we also found that HSP60 could inhibit PRRSV replication in a MAVS-dependent manner, which indicated that HSP60 was a novel antiviral protein against PRRSV replication. In conclusion, the study demonstrated that miR-382-5p was upregulated during PRRSV infection and may promote PRRSV replication by negatively regulating the production of type I interferon, which also indicated that miR-382-5p and HSP60 might be the potential therapeutic targets for anti-PRRSV. K E Y W O R D S antiviral protein, HSP60, MAVS 4498 | CHANG et Al.

show abstract

Section: Discussionsupporting

confidence: 60%

miR‐382‐5p promotes porcine reproductive and respiratory syndrome virus (PRRSV) replication by negatively regulating the induction of type I interferon

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is out of the scope of this review to give details on these pathophysiological situations. They are described in recent essays and compilations related to its involvement in infections, neurodegenerative diseases, cardiac diseases, stroke, metabolic diseases, cancer, asthma, aging and others [3,14,51,52,53]. Below we will focus our attention on immune disorders in which HSPA8 defaults have been described.…”

Section: Hspa8 and Immune Disordersmentioning

confidence: 99%

HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates

Bonam

Ruff²,

Muller

2019

Cells

View full text Add to dashboard Cite

HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. It plays a crucial role in protein quality control, ensuring the correct folding and re-folding of selected proteins, and controlling the elimination of abnormally-folded conformers and of proteins daily produced in excess in our cells. HSPA8 is a crucial molecular regulator of chaperone-mediated autophagy, as a detector of substrates that will be processed by this specialized autophagy pathway. In this review, we shortly summarize its structure and overall functions, dissect its implication in immune disorders, and list the known pharmacological tools that modulate its functions. We also exemplify the interest of targeting HSPA8 to regulate pathological immune dysfunctions.

show abstract

“…HSP protect cancer cells from environmental and pharmacological stress factors and can interfere with cancer therapy. Several studies have demonstrated the relationship between HSP and drug resistance, as well as the possibility of their use as biomarkers for detecting tumors [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Polyallylamine Hydrochloride on Gene Expression and Karyotypic Stability of Multidrug Resistant Transformed Cells

Алексеенко

Шилина

Kozhukharova

et al. 2020

Cells

View full text Add to dashboard Cite

The synthetic polymer, polyallylamine hydrochloride (PAA), is found in a variety of applications in biotechnology and medicine. It is used in gene and siRNA transfer, to form microcapsules for targeted drug delivery to damaged and tumor cells. Conventional chemotherapy often does not kill all cancer cells and leads to multidrug resistance (MDR). Until recently, studies of the effects of PAA on cells have mainly focused on their morphological and genetic characteristics immediately or several hours after exposure to the polymer. The properties of the cell progeny which survived the sublethal effects of PAA and resumed their proliferation, were not monitored. The present study demonstrated that treatment of immortalized Chinese hamster cells CHLV-79 RJK sensitive (RJK) and resistant (RJKEB) to ethidium bromide (EB) with cytotoxic doses of PAA, selected cells with increased karyotypic instability, were accompanied by changes in the expression of p53 genes c-fos, topo2-α, hsp90, hsc70. These changes did not contribute to the progression of MDR, accompanied by the increased sensitivity of these cells to the toxic effects of doxorubicin (DOX). Our results showed that PAA does not increase the oncogenic potential of immortalized cells and confirmed that it can be used for intracellular drug delivery for anticancer therapy.

show abstract

Heat-Shock Proteins in Diagnosis and Treatment: An Overview of Different Biochemical and Immunological Functions

Cited by 47 publications

References 229 publications

miR‐382‐5p promotes porcine reproductive and respiratory syndrome virus (PRRSV) replication by negatively regulating the induction of type I interferon

miR‐382‐5p promotes porcine reproductive and respiratory syndrome virus (PRRSV) replication by negatively regulating the induction of type I interferon

HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates

Impact of Polyallylamine Hydrochloride on Gene Expression and Karyotypic Stability of Multidrug Resistant Transformed Cells

Contact Info

Product

Resources

About