Heat Shock Proteins in Stress in Teleosts

Mohanty, Bimal Prasanna; Mahanty, Arabinda; Mitra, Tandrima; Sc, Parija; Mohanty, Sasmita

doi:10.1007/978-3-319-74715-6_4

Cited by 39 publications

(24 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, previous studies demonstrated that the excess production of HSPs increased TNFα, IL-1β, and IL-12 levels (Lehner et al, 2000;Mohanty et al, 2018;Panjwani et al, 2002). Collectively, the results of this study indicated that ammonia exposure induced a significant immune response in the body of large-scale loach.…”

Section: F I G U R Esupporting

confidence: 67%

High concentrations of environmental ammonia induced changes in large‐scale loach (Paramisgurnus dabryanus) immunity

Zhang

Shang

Wang

et al. 2021

Ecology and Evolution

View full text Add to dashboard Cite

show abstract

Section: F I G U R Esupporting

confidence: 67%

High concentrations of environmental ammonia induced changes in large‐scale loach (Paramisgurnus dabryanus) immunity

Zhang

Shang

Wang

et al. 2021

Ecology and Evolution

View full text Add to dashboard Cite

show abstract

“…Small heat-shock proteins (sHSPs) are found in both humans and fish, with ten sHSPs identified in humans and an additional three sHSPs identified in zebrafish [30]. Most of the thirteen sHSPs are expressed during zebrafish development, including hspb9 and hspb11 [30,88]. In our analysis, we found that expression of hspb9 and hspb11 correlated with the phenotypic outcomes to propoxur exposure.…”

Section: Discussionmentioning

confidence: 69%

Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11

Shields

Hales

Ranspach

et al. 2019

Toxics

View full text Add to dashboard Cite

Recent studies suggest that organophosphates and carbamates affect human fetal development, resulting in neurological and growth impairment. However, these studies are conflicting and the extent of adverse effects due to pesticide exposure warrants further investigation. In the present study, we examined the impact of the carbamate insecticide propoxur on zebrafish development. We found that propoxur exposure delays embryonic development, resulting in three distinct developmental stages: no delay, mild delay, or severe delay. Interestingly, the delayed embryos all physically recovered 5 days after exposure, but behavioral analysis revealed persistent cognitive deficits at later stages. Microarray analysis identified 59 genes significantly changed by propoxur treatment, and Ingenuity Pathway Analysis revealed that these genes are involved in cancer, organismal abnormalities, neurological disease, and hematological system development. We further examined hspb9 and hspb11 due to their potential roles in zebrafish development and found that propoxur increases expression of these small heat shock proteins in all of the exposed animals. However, we discovered that less significant increases were associated with the more severely delayed phenotype. This raises the possibility that a decreased ability to upregulate these small heat shock proteins in response to propoxur exposure may cause embryos to be more severely delayed.

show abstract

“…Lactate is a product of anaerobic glycolysis activated under deficient oxygen supply [25], and its concentration was determined to disclose the possible local occlusions of the hemolymph flow caused by the microcapsules. HSP70 are considered by many authors as a sensitive biomarker that responds to a variety of stressors, including toxic effects and hypoxia [46,47,48]. GST activity and lactate concentrations monitored for two weeks, as well as HSP70 concentration evaluated for one week, showed no reaction (all p > 0.15) to the injections (Figure 4).…”

Section: Resultsmentioning

confidence: 99%

Application of PEG-Covered Non-Biodegradable Polyelectrolyte Microcapsules in the Crustacean Circulatory System on the Example of the Amphipod Eulimnogammarus verrucosus

et al. 2019

View full text Add to dashboard Cite

Layer-by-layer assembled microcapsules are promising carriers for the delivery of various pharmaceutical and sensing substances into specific organs of different animals, but their utility in vivo inside such an important group as crustaceans remains poorly explored. In the current study, we analyzed several significant aspects of the application of fluorescent microcapsules covered by polyethylene glycol (PEG) inside the crustacean circulatory system, using the example of the amphipod Eulimnogammarus verrucosus. In particular, we explored the distribution dynamics of visible microcapsules after injection into the main hemolymph vessel; analyzed the most significant features of E. verrucosus autofluorescence; monitored amphipod mortality and biochemical markers of stress response after microcapsule injection, as well as the healing of the injection wound; and finally, we studied the immune response to the microcapsules. The visibility of microcapsules decreased with time, however, the central hemolymph vessel was confirmed to be the most promising organ for detecting the spectral signal of implanted microencapsulated fluorescent probes. One million injected microcapsules (sufficient for detecting stable fluorescence during the first hours after injection) showed no toxicity for six weeks, but in vitro amphipod immune cells recognize the PEG-coated microcapsules as foreign bodies and try to isolate them by 12 h after contact.

show abstract

Heat Shock Proteins in Stress in Teleosts

Cited by 39 publications

References 94 publications

High concentrations of environmental ammonia induced changes in large‐scale loach (Paramisgurnus dabryanus) immunity

High concentrations of environmental ammonia induced changes in large‐scale loach (Paramisgurnus dabryanus) immunity

Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11

Application of PEG-Covered Non-Biodegradable Polyelectrolyte Microcapsules in the Crustacean Circulatory System on the Example of the Amphipod Eulimnogammarus verrucosus

Contact Info

Product

Resources

About