Heat Shock Proteins in the Human Periodontal Disease Process

Ando, Tomohiro; Kato, Tsuyoshi; Ishihara, Kazuyuki; Ogiuchi, Hideki; Okuda, K

doi:10.1111/j.1348-0421.1995.tb02208.x

Cited by 69 publications

(59 citation statements)

References 19 publications

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“…Sera from ten healthy individuals did not react with A. actinomycetemcomitans GroEL, whereas sera from nine of 29 patients with periodontitis reacted strongly (Koga et al, 1993). Ando et al (1995) also demonstrated that serum from a periodontitis patient contained antibodies that reacted with A. actinomycetemcomitans, F. nucleatum, and P. nigrescens HSP60 and/or HSP70, suggesting that these proteins may be involved in the pathogenesis of periodontitis. Inbred strains of mice immunized with sonic extracts of A. actinomycetemcomitans showed a primary immune response against a 65-kDa protein, which is likely GroEL (Nitta and Ishikawa, 1993).…”

Section: (52) Hsps As Immunodominant Antigensmentioning

confidence: 92%

“…No reactions were found with samples from healthy control patients. Blood vessel endothelial cells, gingival basal cells, and infiltrated inflammatory cells from periodontitis patients also react with monoclonal anti-bovine brain HSP70 and monoclonal anti-human HSP60 antibodies (Ando et al, 1995). Tabeta et al (2000) reported that gingival tissue extracts from healthy or periodontitis patients contain antibodies to the GroEL protein of P. gingivalis.…”

Section: (51) Expression Of Hsps In Diseased Periodontal Tissuesmentioning

confidence: 99%

“…Ando et al (1995) reported that inflamed human gingival tissues from periodontitis patients reacted with monoclonal anti-bovine brain HSP70 and monoclonal anti-human HSP60 antibodies. No reactions were found with samples from healthy control patients.…”

Section: (51) Expression Of Hsps In Diseased Periodontal Tissuesmentioning

confidence: 99%

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Oral Microbial Heat-shock Proteins and Their Potential Contributions to Infections

Goulhen

Grenier

Mayrand

2003

Critical Reviews in Oral Biology & Medicine

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ABSTRACT:The oral cavity is a complex ecosystem in which several hundred microbial species normally cohabit harmoniously. However, under certain special conditions, the growth of some micro-organisms with a pathogenic potential is promoted, leading to infections such as dental caries, periodontal disease, and stomatitis. The physiology and pathogenic properties of micro-organisms are influenced by modifications in environmental conditions that lead to the synthesis of specific proteins known as the heat-shock proteins (HSPs). HSPs are families of highly conserved proteins whose main role is to allow micro-organisms to survive under stress conditions. HSPs act as molecular chaperones in the assembly and folding of proteins, and as proteases when damaged or toxic proteins have to be degraded. Several pathological functions have been associated with these proteins. Many HSPs of oral micro-organisms, particularly periodontopathogens, have been identified, and some of their properties-including location, cytotoxicity, and amino acid sequence homology with other HSPs-have been reported. Since these proteins are immunodominant antigens in many human pathogens, studies have recently focused on the potential contributions of HSPs to oral diseases. The cytotoxicity of some bacterial HSPs may contribute to tissue destruction, whereas the presence of common epitopes in host proteins and microbial HSPs may lead to autoimmune responses. Here, we review the current knowledge regarding HSPs produced by oral micro-organisms and discuss their possible contributions to the pathogenesis of oral infections.

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Section: (52) Hsps As Immunodominant Antigensmentioning

confidence: 92%

Section: (51) Expression Of Hsps In Diseased Periodontal Tissuesmentioning

confidence: 99%

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Oral Microbial Heat-shock Proteins and Their Potential Contributions to Infections

Goulhen

Grenier

Mayrand

2003

Critical Reviews in Oral Biology & Medicine

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“…Hsps play a significant role in pathogenesis of atherosclerosis and acute myocardial events (Ando, Kato, Ishihara, Ogiuchi & Okuda, 1995;Choi, et al, 2002;Ford et al 2006). …”

Section: Chronic Infections and Systemic Inflammatory Biomarkers Accmentioning

confidence: 99%

Association between acute myocardial infarction and periodontitis: A case-control study with north Indian population.

Sidhu¹

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“…Production of superantigens and of heat shock proteins (HSPs) is closely associated with changing host responses [1][2][3][6][7][8]21,22,26,27) . This study was designed to evaluate the significance of infections by M. salivarium and M. orale in HIV(‫)ם‬ patients.…”

Section: Mycoplasma Salivarium and Mycoplasma Oralementioning

confidence: 99%

Heat shock protein of Mycoplasma salivarium and Mycoplasma orale strains isolated from HIV-seropositive patients.

Chattin-Kacouris

Ishihara

Miura

et al. 2002

Bull. Tokyo Dent. Coll.

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It has been suggested that infection by some mycoplasma species can act as possible cofactors in the acceleration of immunodeficiency in HIV-infected patients. The present study was designed to examine infections by oral mycoplasma species in HIV-seropositive (HIV(‫))ם‬ patients. Mycoplasma salivarium and Mycoplasma orale were isolated from 59.5% and 16.7% of 42 HIV(‫)ם‬ patients, respectively. Non-M. salivarium and non-M. orale species were isolated from 40.5% of saliva samples from the HIV(‫)ם‬ group and 20.8% of those from 24 HIV-seronegative (HIV(‫))מ‬ subjects, respectively. Although the production of superantigen by human peripheral lymphocytes in the isolated mycoplasma species from HIV(‫)ם‬ and HIV ‫)מ(‬ subjects was evaluated, none of the examined mycoplasma strains, including ATCC strains of M.salivarium, M. orale, Mycoplasma buccae and Mycoplasma penetrans, were found to produce superantigen. Production of heat shock proteins (HSPs) by isolated mycoplasma strains was examined by immunoblotting using monoclonal antibodies against Helicobacter pylori HSP60. It was found that all the strains of M. salivarium, M.orale, and unidentified mycoplasma species isolated from HIV(‫)ם‬ and HIV(‫)מ‬ groups produced heat shock proteins. HSP production by oral mycoplasma may play a role in the immunomodulation of HIV(‫)ם‬ patients.

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Heat Shock Proteins in the Human Periodontal Disease Process

Cited by 69 publications

References 19 publications

Oral Microbial Heat-shock Proteins and Their Potential Contributions to Infections

Oral Microbial Heat-shock Proteins and Their Potential Contributions to Infections

Association between acute myocardial infarction and periodontitis: A case-control study with north Indian population.

Heat shock protein of Mycoplasma salivarium and Mycoplasma orale strains isolated from HIV-seropositive patients.

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