2017
DOI: 10.3390/ijms18122709
|View full text |Cite
|
Sign up to set email alerts
|

Heat Shock Proteins in Vascular Diabetic Complications: Review and Future Perspective

Abstract: Heat shock proteins (HSPs) are a large family of proteins highly conserved throughout evolution because of their unique cytoprotective properties. Besides assisting protein refolding and regulating proteostasis under stressful conditions, HSPs also play an important role in protecting cells from oxidative stress, inflammation, and apoptosis. Therefore, HSPs are crucial in counteracting the deleterious effects of hyperglycemia in target organs of diabetes vascular complications. Changes in HSP expression have b… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
54
0

Year Published

2019
2019
2021
2021

Publication Types

Select...
5
2
1

Relationship

0
8

Authors

Journals

citations
Cited by 58 publications
(54 citation statements)
references
References 152 publications
(186 reference statements)
0
54
0
Order By: Relevance
“…This in vitro study provided an alternative explanation for the mechanism underlying adiponectin action. Given that the alteration of HSP60 protein levels have been demonstrated in diabetic complications and functionally related to hyperglycemia-induced cell injury [19], our findings will also advance our insights into basic mechanisms of HSP60 function.…”
Section: Resultsmentioning
confidence: 69%
See 2 more Smart Citations
“…This in vitro study provided an alternative explanation for the mechanism underlying adiponectin action. Given that the alteration of HSP60 protein levels have been demonstrated in diabetic complications and functionally related to hyperglycemia-induced cell injury [19], our findings will also advance our insights into basic mechanisms of HSP60 function.…”
Section: Resultsmentioning
confidence: 69%
“…On the other hand, serum HSP60 has been recognized as a potent inductor of proinflammatory mediators in various cells indulging innate immune cells, skeletal muscle, cardiomyocytes, and adipocytes [11,[15][16][17]. Furthermore, the high levels of serum HSP60 have been found in the individuals with adjuvant arthritis and atherosclerosis [18,19].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…PTPRN2 encodes a major islet autoantigen in T1D, which plays an important role in insulin secretion in response to glucose stimuli by accumulating normal levels of insulin-containing vesicles and preventing its degradation [Lee, 2019]. HSPD1 is considered a pro-or anti-apoptotic regulator of apoptosis, depending on the circumstances [Aluksanasuwan et al, 2017], whose high-levels have been associated with diabetes as well as increased expression of inflammatory genes and release of pro-inflammatory cytokines [Blasi et al, 2012;Bellini et al, 2017]. In the TC analysis using the personalised approach, case-control pairs 2, 7, 9 and 10 differentially down-regulated only the PTPRN2 gene; pair 3 down-regulated only the HSPD1 gene; and pair 8 down-regulated HSPD1, but up-regulated PTPRN2.…”
Section: Identifying Differentially Expressed Genesmentioning
confidence: 99%
“…has been recognized as a potent inductor of proinflammatory mediators in various cells indulging innate immune cells, skeletal muscle, cardiomyocytes, and adipocytes [11,[15][16][17]. Furthermore, the high levels of serum HSP60 have been found in the individuals with adjuvant arthritis and atherosclerosis [18,19].…”
mentioning
confidence: 99%