Heat stress affects duodenal microbial community of indigenous yellow-feather broilers as determined by 16S rRNA sequencing

Liang, Zi-Long; Jin, Yongyan; Guo, Yan; Qiu, Sheng-Jian; Zhao, Yue; Zhao, Zhihui; Li, Wenchao

doi:10.1080/1828051x.2021.1970034

Cited by 6 publications

(4 citation statements)

References 52 publications

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“…As the main intestinal segment where Peyer’s patches are distributed, ileum plays a significant role in immune homeostasis by regulating gut microbiota through interactions involving IgA and epithelial barriers, enhancing disease resistance and environmental adaptability [ 106 – 109 ]. Additionally, the interactions between the host and the gut microbiome influences host metabolic processes and adaptability to diverse climates [ 110 – 116 ], underscoring the pivotal role of ileum in physiological resilience. In contrast, the spleen and stomach did not appear to have a specific role in the adaptation of domestic pigs to tropical, high-altitude, or frigid environments.…”

Section: Discussionmentioning

confidence: 99%

Whole-genome analysis reveals distinct adaptation signatures to diverse environments in Chinese domestic pigs

Wang,

Song,

Yao

et al. 2024

J Animal Sci Biotechnol

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Background Long-term natural and artificial selection has resulted in many genetic footprints within the genomes of pig breeds across distinct agroecological zones. Nevertheless, the mechanisms by which these signatures contribute to phenotypic diversity and facilitate environmental adaptation remain unclear. Results Here, we leveraged whole-genome sequencing data from 82 individuals from 6 domestic pig breeds originating in tropical, high-altitude, and frigid regions. Population genetic analysis suggested that habitat isolation significantly shaped the genetic diversity and contributed to population stratification in local Chinese pig breeds. Analysis of selection signals revealed regions under selection for adaptation in tropical (55.5 Mb), high-altitude (43.6 Mb), and frigid (17.72 Mb) regions. The potential functions of the selective sweep regions were linked to certain complex traits that might play critical roles in different geographic environments, including fat coverage in frigid environments and blood indicators in tropical and high-altitude environments. Candidate genes under selection were significantly enriched in biological pathways involved in environmental adaptation. These pathways included blood circulation, protein degradation, and inflammation for adaptation to tropical environments; heart and lung development, hypoxia response, and DNA damage repair for high-altitude adaptation; and thermogenesis, cold-induced vasodilation (CIVD), and the cell cycle for adaptation to frigid environments. By examining the chromatin state of the selection signatures, we identified the lung and ileum as two candidate functional tissues for environmental adaptation. Finally, we identified a mutation (chr1: G246,175,129A) in the cis-regulatory region of ABCA1 as a plausible promising variant for adaptation to tropical environments. Conclusions In this study, we conducted a genome-wide exploration of the genetic mechanisms underlying the adaptability of local Chinese pig breeds to tropical, high-altitude, and frigid environments. Our findings shed light on the prominent role of cis-regulatory elements in environmental adaptation in pigs and may serve as a valuable biological model of human plateau-related disorders and cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

Whole-genome analysis reveals distinct adaptation signatures to diverse environments in Chinese domestic pigs

Wang,

Song,

Yao

et al. 2024

J Animal Sci Biotechnol

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“…To address this, studies have reported that co-enzyme q10 protects the chicken primary myocardial cells against damage and apoptosis during in vivo heat stress by upregulating hsp70 expression and HSF1 binding activity ( Xu et al, 2017a ; Xu et al, 2017b ; Xu et al, 2019b ), and that co-enzyme q10 induced autophagy and suppressed the PI3K/AKT/mTOR signaling as a protective mechanism against heat stress ( Xu et al, 2019a ). Alongside this, several studies have employed the whole transcriptomics approach, as well as other RNA sequencing technology to investigate the effects of heat stress in poultry ( Saelao et al, 2018 ; Te Pas et al, 2019 ; Kim et al, 2021 ; Liang et al, 2021 ). With the advent of this tool, the molecular mechanisms that occur in distinct cells or tissues of various poultry species during heat stress exposure can be profiled, quantified, and comprehensively understood, thus presenting useful information to advance research in this field.…”

Section: Discussionmentioning

confidence: 99%

Global trends and research frontiers on heat stress in poultry from 2000 to 2021: A bibliometric analysis

Uyanga

Musa²,

Oke

et al. 2023

Front. Physiol.

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Background: Heat stress remains a major environmental factor affecting poultry production. With growing concerns surrounding climate change and its antecedent of global warming, research on heat stress in poultry has gradually gained increased attention. Therefore, this study aimed to examine the current status, identify the research frontiers, and highlight the research trends on heat stress in poultry research using bibliometric analysis.Methods: The literature search was performed on the Web of Science Core Collection database for documents published from 2000 to 2021. The documents retrieved were analyzed for their publication counts, countries, institutions, keywords, sources, funding, and citation records using the bibliometric app on R software. Network analysis for co-authorship, co-occurrence, citation, co-citation, and bibliographic coupling was visualized using the VOSviewer software.Results: A total of 468 publications were retrieved, and over the past two decades, there was a gradual increase in the annual number of publications (average growth rate: 4.56%). China had the highest contribution with respect to the number of publications, top contributing authors, collaborations, funding agencies, and institutions. Nanjing Agricultural University, China was the most prolific institution. Kazim Sahin from Firat University, Turkey contributed the highest number of publications and citations to heat stress in poultry research, and Poultry Science was the most productive and the most cited journal. The top 10 globally cited documents mainly focused on the effects of heat stress, alleviation of heat stress, and the association between heat stress and oxidative stress in poultry. All keywords were grouped into six clusters which included studies on “growth performance”, “intestinal morphology”, “heat stress”, “immune response”, “meat quality”, and “oxidative stress” as current research hotspots. In addition, topics such as; “antioxidants”, “microflora”, “intestinal barrier”, “rna-seq”, “animal welfare”, “gene expression”, “probiotics”, “feed restriction”, and “inflammatory pathways” were identified for future research attention.Conclusion: This bibliometric study provides a detailed and comprehensive analysis of the global research trends on heat stress in poultry over the last two decades, and it is expected to serve as a useful reference for potential research that will help address the impacts of heat stress on poultry production globally.

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“…As the undertaker of respiration, the role played by the lung in the process of adapting to various environments was well studied. Numerous investigations have demonstrated that interactions between the host and its microbiome can effectively modulate host adaptability [94][95][96][97][98][99][100] and that host genetic selection can affect gut microbiome composition [101,102]. We, therefore, hypothesize that gut-speci c regulatory elements indirectly regulate gut microbiome composition during pig environmental adaptations.…”

Section: Chromatin State Annotation and Cis-regulatory Mutationsmentioning

confidence: 99%

Whole-genome analysis reveals distinct adaptation signatures to diverse environments in Chinese domestic pigs

Wang,

Song,

Yao

et al. 2024

Preprint

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Background:Long-term natural and artificial selection resulted in many genetic footprints within the genomes of pig breeds across distinct agroecological zones. Nevertheless, the mechanisms of how these signatures contribute to phenotypic diversity and facilitate environmental adaptation remain unclear. Results: Here, we leveraged whole-genome sequencing data of 82 individuals from six domestic pig breeds originating in tropical, frigid, and high-altitude regions. Population genetic analysis suggested that environmental adaptations significantly contributed to population stratification in Chinese local pig breeds. Analysis of selection signals identified regions under selection for tropical adaptation (55.5 Mb), high-altitude adaptation (43.6 Mb), and frigid adaptation (17.72 Mb). The potential functions of the selective sweep regions were linked to certain complex traits that might play critical roles in different geographic environments, including fat coverage in frigid environments and blood indicators in tropical and high-altitude environments. Candidate genes under selection were significantly enriched in the biological pathways involved in environmental adaptations. These pathways contained blood circulation, protein degradation, and inflammation for tropical adaptation; heart and lung development, hypoxia response, and DNA damage repair for high-altitude adaptation; andthermogenesis, cold-induced vasodilation (CIVD), and cell cycle for frigid adaptation. By examining the chromatin state of the selection signatures, we detected the lung and ileum as two critically functional tissues for environmental adaptations. Finally, we unveiled a mutation (chr1: G246,175,129A) in cis-regulatory regions of ABCA1 as a plausible promising variant for tropical adaptation. Conclusions: In this study, we conducted a genome-wide exploration of the genetic mechanisms underlying the tropical, frigid, and high-altitude adaptability of Chinese local pig breeds. Our findings shed light on the prominent role of cis-regulatory elements in impacting environmental adaptation in pigs and may serve as a vital biomodel on human plateau-related disorders and cardiovascular diseases.

show abstract

Heat stress affects duodenal microbial community of indigenous yellow-feather broilers as determined by 16S rRNA sequencing

Cited by 6 publications

References 52 publications

Whole-genome analysis reveals distinct adaptation signatures to diverse environments in Chinese domestic pigs

Whole-genome analysis reveals distinct adaptation signatures to diverse environments in Chinese domestic pigs

Global trends and research frontiers on heat stress in poultry from 2000 to 2021: A bibliometric analysis

Whole-genome analysis reveals distinct adaptation signatures to diverse environments in Chinese domestic pigs

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