Heat-stress-induced damage to porcine small intestinal epithelium associated with downregulation of epithelial growth factor signaling1

Liu, F.; Yin, Jingdong; Du, Min; Yan, Peishi; Xu, Jianqin; Zhu, Xiaoyu; Yu, Jin

doi:10.2527/jas.2008-1624

Cited by 111 publications

(87 citation statements)

References 39 publications

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“…The gastro intestinal tract is particularly responsive to stressors like heat stress, which modify the normal and protective microbiota (Bailey et al, 2004) and decreased integrity of the intestinal epithelium (Lambert, 2009) which in turn can affect its barrier function and the absorption of nutrients, impairing productive performance of animals (Liu et al, 2009).…”

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confidence: 99%

Growth performance and gut health parameters of finishing broilers supplemented with plant extracts and exposed to daily increased temperature

Akbarian

Golian

Kermanshahi

et al. 2013

Span. j. agric. res.

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The effects of three plant extracts, i.e. lemon peel extract (LPE), orange peel extract (OPE) and Curcuma xanthorrhiza essential oil (CXEO), on the performance and gut health parameters of broilers exposed to high temperature was investigated. A total of 336 unsexed Ross 308 broilers were distributed to seven dietary treatments, a control diet and six diets containing 200 or 400 mg kg-1 feed of one of the three products between d 25-38 (12 chicks per pen, four replicates). To induce chronic heat stress, the temperature was increased to 34°C with 50% relative humidity for 5 h daily starting from d 28 until d 38. At d 38, four animals per pen were sampled for morphological characteristics (duodenum, jejunum and ileum) and microbial counts (ileo-cecal contents). Plant extracts did not affect the bird performance. The bursa weight of the control birds was lower (p<0.05) comparing to those fed 400 mg kg-1 OPE and 200 and 400 mg kg-1 CXEO diets. Feeding 400 mg kg-1 of LPE decreased the duodenal villus:crypt ratio compared to control and 200 mg kg-1 OPE fed birds. Plant extracts did not have effect on ileal histo-morphology. Feeding with 400 mg kg-1 of LPE and CXEO caused a decrease in coliform counts in ileum and feeding of 400 mg kg-1 CXEO diet decreased coliform counts in caecum compared to control birds (p<0.05). These results elucidate that CXEO, OPE and LPE might modify some microbial and intestinal traits, but without beneficial effect on performance of broilers under heat stress.

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confidence: 99%

Growth performance and gut health parameters of finishing broilers supplemented with plant extracts and exposed to daily increased temperature

Akbarian

Golian

Kermanshahi

et al. 2013

Span. j. agric. res.

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“…6,7,13 furthermore, the expression of micrornas in rat small intestine was negatively correlated with their predicted gene targets during heat stress. 12 Heat stress triggers complex tissue and cellular responses, including not only physiological and biochemical compensation but also altered gene expression.…”

Section: Figmentioning

confidence: 94%

“…6 this injury to intestinal epithelial cells may disrupt the intestinal barrier and reduce absorptive function.…”

Section: Figmentioning

confidence: 99%

“…4 During this reduction in blood flow, the epithelial tissue of the small intestine can experience ischemic and hypoxic conditions, resulting in tissue damage, which can in turn lead to diarrhea and an increased risk of morbidity and mortality. [5][6][7] although there is substantial literature on the effects of heat stress on the small intestine of various animals, the molecular mechanisms underlying its pathophysiology remain to be defined. Heat stress has been shown to result in a complex cellular response, including alterations in gene expression and biochemical adaptations.…”

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Microarray Analysis of Gene Expression Profiles of Rat Small Intestine in Response to Heat Stress

Wang

Hou

et al. 2011

SLAS Discovery

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Ambient temperature is a critical factor that affects biological organisms in many ways. In this study, the authors investigated gene expression changes in rat small intestine in response to heat stress. Male Sprague-Dawley rats were randomly divided into control and heat-stressed groups. Both groups were housed at 25 °C, although the heat-stressed group was also subjected to 40 °C for 2 h each day for 10 successive days. Rats were sacrificed 1, 3, 6, and 10 days after heat treatment, and sections of their small intestine epithelial tissue were excised for morphological examination and microarray analyses. The rat rectal and body surface temperatures and serum cortisol levels were all significantly increased after heat treatment (p < 0.05). The jejuna were significantly damaged by 3 days after heat treatment began. Microarray analysis showed that 422 genes were differentially expressed, of which 290 genes were significantly upregulated and 132 genes were significantly downregulated. Subsequent bioinformatics analyses revealed that the differentially expressed genes were mainly related to stress, immune regulation, and metabolism processes. The bioinformatics analysis of the differentially expressed genes should be beneficial to further investigations on the underlying mechanisms involved in heat stress–induced damage in the small intestine.

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“…and Mader, T.L., 1997;Hubbard, K.G. et al, 1999) or issues with growth and reproduction (Forbes, J.M., 2007), (Fuquay, J.W., 1981), (Liu, F. et al, 2009). Most of these studies have focused on usingbody temperature (Tb) or panting levels as measures of heat stress.…”

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confidence: 99%

Statistical Considerations When Using Hysteresis to Estimate Internal Heat Load in Dairy Cows

Maynes¹,

Parkhurst²

2012

Conference on Applied Statistics in Agriculture

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Water is often used to manage heat stress in dairy cattle. Sprinklers are often placed over the feed bunk or used while cattle are waiting to be milked, however in this experiment cattle were given control over water with a cow-activated shower. Previous studies have focused on how wetting can lower body temperature or reduce respiration rates. An alternative way to investigate this management practice is to examine internal heat loads. Internal heat load can be quantified by fitting a hysteresis loop to daily field data. The hysteresis loop is formed by a phase diagram of body temperature versus an environmental input. Internal heat load is the area inside the loop.The area can be estimated using a number of environmental measures. In this paper three environmental measures are considered: ambientair temperature, the temperature-humidity index and the heat-load index. The two stage harmonic least squares methodis used to estimate internal heat load. Then a Bayesian MCMC model is used to predict internal heat load using the environmental inputs and test the effectiveness of allowing shower access on internal heat load reduction. Voluntary use of a shower reduces internal heat load and the strength of this effect increases with the degree of the heat challenge.

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Heat-stress-induced damage to porcine small intestinal epithelium associated with downregulation of epithelial growth factor signaling1

Cited by 111 publications

References 39 publications

Growth performance and gut health parameters of finishing broilers supplemented with plant extracts and exposed to daily increased temperature

Growth performance and gut health parameters of finishing broilers supplemented with plant extracts and exposed to daily increased temperature

Microarray Analysis of Gene Expression Profiles of Rat Small Intestine in Response to Heat Stress

Statistical Considerations When Using Hysteresis to Estimate Internal Heat Load in Dairy Cows

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