Heat stress-induced memory impairment is associated with neuroinflammation in mice

Lee, Wonil; Moon, Minho; Kim, Hyo Geun; Lee, Tae Hee; Oh, Myung Sook

doi:10.1186/s12974-015-0324-6

Cited by 124 publications

(141 citation statements)

References 52 publications

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“…Reductions in brain cell proliferation are widely known to be associated with stress-induced behavioral changes (McEwen and Magarinos, 2001), including cognitive behaviors (Lee et al, 2015). Whether there are additional behavioral consequences of this reduction in brain cell proliferation is not as well-studied, but evidence is beginning to emerge that changes in brain cell proliferation are also involved in anxiety- and depressive-like behaviors.…”

Section: Introductionmentioning

confidence: 99%

The prebiotics 3′Sialyllactose and 6′Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut–brain axis

Tarr

Galley

Fisher

et al. 2015

Brain, Behavior, and Immunity

248

174

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There are extensive bidirectional interactions between the gut microbiota and the central nervous system (CNS), and studies demonstrate that stressor exposure significantly alters gut microbiota community structure. We tested whether oligosaccharides naturally found in high levels in human milk, which have been reported to impact brain development and enhance the growth of beneficial commensal microbes, would prevent stressor-induced alterations in gut microbial community composition and attenuate stressor-induced anxiety-like behavior. Mice were fed standard laboratory diet, or laboratory diet containing the human milk oligosaccharides 3′Sialyllactose (3′SL) or 6′Sialyllactose (6′SL) for two weeks prior to being exposed to either a social disruption stressor or a non-stressed control condition. Stressor exposure significantly changed the structure of the colonic mucosa-associated microbiota in control mice, as indicated by changes in beta diversity. The stressor resulted in anxiety-like behavior in both the light/dark preference and open field tests in control mice. This effect was associated with a reduction in immature neurons in the dentate gyrus as indicated by doublecortin (DCX) immunostaining. These effects were not evident in mice fed milk oligosaccharides; stressor exposure did not significantly change microbial community structure in mice fed 3′SL or 6′SL. In addition, 3′SL and 6′SL helped maintain normal behavior on tests of anxiety-like behavior and normal numbers of DCX+ immature neurons. These studies indicate that milk oligosaccharides support normal microbial communities and behavioral responses during stressor exposure, potentially through effects on the gut microbiota-brain axis.

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Section: Introductionmentioning

confidence: 99%

The prebiotics 3′Sialyllactose and 6′Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut–brain axis

Tarr

Galley

Fisher

et al. 2015

Brain, Behavior, and Immunity

248

174

View full text Add to dashboard Cite

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“…Lee et al. () also reported that exposure to high temperature (43°C) for 7, 14 or 42 days impaired spatial working memory, assessed in Y‐maze, and long‐term memory, assessed by a novel object recognition task, in mice. In the present study, heat stress significantly impaired memory function in the HS‐exposed groups, indicated by slower acquisition and poor retention; however, RC significantly improved memory functions.…”

Section: Discussionmentioning

confidence: 96%

“…High temperature is an environmental stressor that induces several biochemical and behavioural changes (Gordon, ; Lee et al., ). Experimental and clinical evidence shows that exposure to a high temperature can result in cognitive impairment and memory loss, possibly through impairment in the brain structure and functions.…”

Section: Discussionmentioning

confidence: 99%

“…After acclimation, the rats were randomly assigned into two groups as follows: a control group ( n = 12) and a heat stress (HS) group ( n = 48). Animals in the HS group were subjected to heat stress once a day for 2 weeks (Lee, Moon, Kim, Lee, & Oh, ). The HS group was divided into four subgroups (HS, RC250, RC500 and RC1000) and treated with NS, 250, 500 and 1000 mg kg −1 RC extract 1 h before HS exposure by oral gavage, respectively.…”

Section: Methodsmentioning

confidence: 99%

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Rosa caninaL. methanolic extract prevents heat stress‐induced memory dysfunction in rats

Tabatabaei

Sadigh‐Eteghad

Farokhi-Sisakht

et al. 2019

Experimental Physiology

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New Findings What is the central question of this study?Heat stress has harmful effects on the brain structure and synaptic density via induction of oxidative stress and neuroinflammation, which result in neuronal damage in the hippocampus and thereby cognitive impairments. In this study, we investigate the effect of Rosa canina treatment on cognitive function in heat stress‐exposed rats and its underlying mechanisms. What is the main finding and its importance?We show that R. canina improves cognitive deficits induced by heat stress by attenuation of oxidative stress and neuroinflammation and by upregulation of synaptic proteins in the hippocampus. Abstract The aim of the study was to evaluate the effects of aqueous methanolic extract of Rosa canina (RC) dried fruits on oxidative stress, inflammation, synaptic degeneration and memory dysfunction induced by heat stress (HS) in rats. Sixty adult male Wistar rats were randomly divided into five groups as follows: the control group received normal saline (NS); the HS group was exposed to heat stress (43°C) for 15 min once a day for 2 weeks; and HS+R groups were exposed to heat stress and received one of three doses (250, 500 or 1000 mg kg−1) of RC methanolic extract for 2 weeks. A passive avoidance test and a Y‐maze test were performed to assess learning and memory. The levels of reactive oxygen species were assessed. The serum cortisol concentration and hippocampal total antioxidant capacity, superoxide dismutase and glutathione peroxidase were also detected using spectrophotometry. The protein expressions of c‐Fos, heat‐shock protein‐70, tumour necrosis factor‐α, growth‐associated protein 43, post‐synaptic density‐95 and synaptophysin were evaluated in the hippocampal tissue. The results showed that RC significantly improved cognitive dysfunction induced by HS, which was accompanied by downregulation of tumour necrosis factor‐α and upregulation of growth‐associated protein 43 and synaptophysin proteins in the hippocampus of HS‐exposed rats. Furthermore, RC significantly attenuated serum cortisol concentrations and upregulated heat shock protein‐70 and c‐Fos in the hippocampus. In addition, the administration of RC attenuated reactive oxygen species levels and enhanced antioxidant defense in the hippocampus. These findings indicate that RC attenuated the deleterious effect of HS on cognition through its antioxidant properties and by enhancing synaptic function and plasticity.

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“…Previous investigations indicated that minocycline decreases respiratory depression, reward and tolerance caused by morphine in animal models and also apoptosis in the luminar spinal cord and cerebral cortex of rats . Moreover, memory improvement property of minocycline had already been indicated in animal models of Alzheimer and heat stress‐induced memory impairment …”

Section: Discussionmentioning

confidence: 99%

Effect of pretreatment with intracerebroventricular injection of minocycline on morphine‐induced memory impairment in passive avoidance test: Role of P‐CREB and c‐Fos expression in the dorsal hippocampus and basolateral amygdala regions

Hamidkhaniha

Bashiri

Omidi

et al. 2019

Clin Exp Pharma Physio

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Summary Minocycline as a member of the tetracycline family is a lipophilic broad‐spectrum antibiotic, which can display some non‐antibiotic properties such as antioxidant, antiapoptosis, neuroprotection and modulation of pharmacological traits of drugs of abuse (ie, reward, sensitization and/or analgesia). Thus, the aim of the present study was to investigate the effect of intracerebroventricular (ICV) injection of minocycline on morphine‐induced memory impairment and motor function in male Wistar rats. The behavioural responses were measured by a passive avoidance test for evaluating memory, and in the open field for studying motor function. Furthermore, the expression of Phospho‐cAMP response element‐binding protein (P‐CREB) and c‐Fos were assessed using immunohistochemistry in the dorsal hippocampus and basolateral amygdala (BLA). Our results showed that morphine dose‐dependently impairs memory consolidation, but not motor function. Maximum effect was achieved with morphine at dose of 5 mg/kg. Pretreatment with ICV injection of minocycline (50 μg/rat) prevented morphine‐induced memory impairment, but there was no effect on motor function. The results of immunohistochemistry analysis demonstrated that morphine decreased expression of P‐CREB positive cells compared to saline control group in the BLA, but not in the dorsal hippocampus. On the other hand, pretreatment of animals with ICV injection of minocycline increased the expression of P‐CREB in both brain areas. Moreover, there was no significant change in the expression of c‐Fos positive cells in above‐mentioned regions. In summary, our results indicated that pretreatment with ICV injection of minocycline prevented morphine‐induced memory impairment and increased P‐CREB expression in the dorsal hippocampus and BLA, which may explain its memory improvement property.

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Heat stress-induced memory impairment is associated with neuroinflammation in mice

Cited by 124 publications

References 52 publications

The prebiotics 3′Sialyllactose and 6′Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut–brain axis

The prebiotics 3′Sialyllactose and 6′Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut–brain axis

Rosa caninaL. methanolic extract prevents heat stress‐induced memory dysfunction in rats

Effect of pretreatment with intracerebroventricular injection of minocycline on morphine‐induced memory impairment in passive avoidance test: Role of P‐CREB and c‐Fos expression in the dorsal hippocampus and basolateral amygdala regions

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