Heat stress triggers apoptosis by impairing NF-κB survival signaling in malignant B cells

Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury

“…17 More recently, 2 independent groups have demonstrated that MRTF-A deficiency attenuates tissue impairment and protects against myocardial infarction and cardiac hypertrophy. 18,19 Our data presented here allude to the notion that activation of MRTF-A underscores the maladaptation of endothelial cells in response to stress exerted by oxLDL, indicating endothelial-specific loss-of-function of MRTF-A would alleviate atherosclerotic injury. Future studies using tissue-specific knockout model of MRTF-A and high-output expression profiling may shed more light on the vascular pathophysiology of MRTF-A.…”

“…[15][16][17][18][19] Small interfering RNA (siRNA) sequences for MRTF-A were as follows: #1, 5'-GUGUCUUGGUGUAGUGUAA-3', #2, 5'-CUGCGUGCAUAUCAAGAACAA-3', #3, 5'-CAGGTGAAUUAUCCGAAAGUA-3'. siRNA sequences for SRF were as follows: #1, 5'-GCAGAGGGCAACUGACUUCAUUUGUG-3', #2, 5'-AUGUUUGCCAUGAGUAUUA-3', #3, 5'-GAAUGAGUGCCACUGGCUU-3'.…”

Two MicroRNAs Encoded within the Bovine Herpesvirus 1 Latency-Related Gene Promote Cell Survival by Interacting with RIG-I and Stimulating NF-κB-Dependent Transcription and Beta Interferon Signaling Pathways

“…Interestingly, dexamethasone, which stimulates BHV-1 reactivation from latency, impairs NF-B signaling (22,86). Heat stress stimulates HSV-1 in vivo reactivation from latency in mice (68) and, like dexamethasone, impairs NF-B signaling (5,63). Thus, there appears to be a link between disrupting NF-B signaling, inducing apoptosis, and increasing the incidence of reactivation from latency.…”

New developments in the pathology of malignant lymphoma: a review of the literature published from October 2009 to January 2010

“…Belardo et al [10] show that heat stress induces downregulation of NF-kappaB in B-cell lymphoma cells resulting in massive apoptosis via downregulation of cIAP-2; this mechanism does not occur in normal B cells.…”