Modern lifestyle, industrialization and economy thrive on energy which is getting expensive overtime. Thermosyphon based systems are getting attraction for their promising heat transfer efficiency and zero energy utilization. Refrigerants having ozone depletion potential (ODP) and high Global Warming Potential (GWP) have been banned or under time bared permission under Montreal (1987) and Kyoto (1997) protocols. We have devolved a Refrigerant Parametric Quantification (RPQ) method for the choice of optimal refrigerant for density driven solar water heaters. A set of 29 refrigerants are simulated Using REFPROP under various temperature and pressure conditions. The optimal parameters of thermosyphon system are identified from governing equations, international environment safety protocols and open literature. The proposed RPQ method shows most appropriate refrigerant for given temperature range. In second part, the proposed system is simulated in TRNSYS using forced circulation method. In the end, a glass evacuated tube collector is developed and tested on the principal of thermosyphon, employing the best refrigerant emerged from simulation study.