Chemical responses are investigated as a piece of the modern applications like hydrometallurgical industry, food processing, and polymer production. Numerous chemical responding structures consolidate homogeneous and heterogeneous response and it is especially eccentric. Hence, this paper explains how the hybrid nanoliquid flow is handy in accelerate the thermochemical possessions of the base fluid in existence of homogeneous-heterogeneous reactions. Here, three different types of hybrid nanoliquid used are copper-Al 2 O 3 / water, silver-Al 2 O 3 /water, and gold-Al 2 O 3 /water. Outcoming differential systems are resolved numerically by adopting fourth-order and fifth-order Runge-Kutta-Fehlberg method. To get better view of the topic, the flow field, temperature behavior, and concentration curves are investigated for particular estimations of critical elements. The results predict that gold-Al 2 O 3 / water nanoliquid has good impact of heat rate coefficient and further porosity parameter decelerates the velocity and accelerates the temperature of the hybrid nanofluid. K E Y W O R D S homogeneous-heterogeneous reactions, hybrid nanoliquid, numerical solutions, porous medium, stretching sheet