This study numerically investigates liquid water dynamics in a novel hybrid sinusoidal flow channel of a proton exchange membrane fuel cell (PEMFC). The two-phase flow is examined using a three-dimensional, transient computational fluid dynamics (CFD) simulation employing the coupled level set and volume of fluid (VOF) method. Simulations for hybrid and non-hybrid sinusoidal flow channels, including a straight flow channel, are compared based on their water exhaust capacities and pressure drops. Additionally, the effects of inlet gas velocity, wall wettability, and droplet interaction in the flow channel on the dynamic behaviour of liquid water are investigated. Results reveal that the novel hybrid sinusoidal channel designs are consistent in terms of quicker water removal under varying hydrophilic wall conditions. Also, it is found that the liquid surface coverage, detachment, and removal rate depends on droplet proximity to the walls, inlet gas velocity, and wall contact angle. Also, the time a droplet makes contact with the side walls affect the discharge time. Additionally, there is an improvement in the gas velocity magnitude and vertical component velocity across the hybrid sinusoidal channel designs. Therefore, the unique geometric configuration of the proposed hybrid Design makes it a viable substitute for water management in PEMFC applications.