To achieve acme heat transfer is our main disquiet in many heat transfer applications such as radiators, heat sinks and heat exchangers. Due to furtherance in technology, requirement for efficient systems have increased. Usually cooling medium used in these applications is liquid which carries away heat from system. Liquids have poor thermal conductivity as compared to solids. In order to improve the efficiency of system, cooling medium with high thermal conductivity should be used. Quest to improve thermal conductivity leads to usage of different methods, and one of them is addition of nanoparticles to base liquid. Application of nanofluids (a mixture of nanoparticles and base fluid) showed enhancement in heat transfer rate, which is not possible to achieve by using simple liquids. Different researchers used TiO 2 nanoparticles in different heat transfer applications to observe the effects. Addition of titanium oxide nanoparticles into base fluid showed improvement in the thermal conductivity of fluid. This chapter will give an overview of usage of titanium oxide nanoparticles in numerous heat transfer applications.