Heat-Treated Emulsions with Cross-Linking Bovine Serum Albumin Interfacial Films and Different Dextran Surfaces: Effect of Paclitaxel Delivery

Qi, Jianing; Huang, Chong; He, Fei; Yao, Ping

doi:10.1002/jps.23468

Cited by 13 publications

(19 citation statements)

References 35 publications

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“…After 120 days of storage, all the emulsions were homogeneous in appearance, their D h values did not change significantly, indicating that all the emulsions had long-term physical stability. It is reasonable that the emulsions had good stability because the droplets were protected and stabilized by the crosslinked interfacial film and were dispersed in aqueous solutions by the conjugated dextran chains as reported previously (Qi et al., 2013 ; Wang et al., 2016 ).…”

Section: Resultssupporting

confidence: 64%

“…BD/PRO complex was used as emulsifier to produce @BD/PRO. After emulsification at pH 6.0, the produced emulsion was heat-treated at 90 °C for 1 h to cause BSA denaturation and gelation, consequently to form crosslinked oil–water interfacial film (Qi et al., 2013 ; Wang et al., 2016 ). The heat treatment did not result in the PRO degradation and conformation change, verified by Figure S1 of Supplementary material , which shows the identical CD spectra of the individual PRO aqueous solution before and after the heat treatment.…”

Section: Resultsmentioning

confidence: 99%

“…BD was prepared by Maillard reaction as reported previously (Qi et al., 2013 ; Wang et al., 2016 ). Briefly, BSA and dextran were dissolved together in deionized water with a feed-molar ratio of BSA to dextran 1:6 (weight ratio of BSA to dextran 1:0.9); the mixed solution was adjusted to pH 8.0 and then lyophilized.…”

Section: Methodsmentioning

confidence: 99%

“…Herein, we introduced PRO into BSA–dextran conjugate (BD) emulsion to increase the absorption in intestines and thus increase the oral bioavailability as well as therapeutic efficacy of the encapsulated hydrophobic drug. BD was produced by a nontoxic Maillard reaction (Qi et al., 2013 ; Wang et al., 2016 ), which links the reducing end carbonyl group of dextran to the amino group of BSA. BD is negatively charged in pH 6 solution, and therefore can bind with positively charged PRO, forming electrostatic complex BD/PRO.…”

Section: Introductionmentioning

confidence: 99%

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Protamine and BSA–dextran complex emulsion improves oral bioavailability and anti-tumor efficacy of paclitaxel

Bao

Yao

2020

Drug Delivery

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Food protein and polysaccharide complex emulsions are safe carriers of hydrophobic drugs and nutrients. To improve oral bioavailability and therapeutic/healthy efficacy of hydrophobic drugs and nutrients, herein, protamine (PRO), a cationic cell-penetrating peptide, was introduced into protein and polysaccharide complex emulsion. The electrostatic complex of PRO and BSA–dextran conjugate (BD) produced by Maillard reaction was used as emulsifier to produce oil-in-water emulsion (@BD/PRO). The BSA molecules were crosslinked at the oil–water interface by a heat treatment and the PRO chains were simultaneously anchored in the interface. BD emulsion (@BD) without PRO was produced for comparation. Paclitaxel (PTX), a hydrophobic antineoplastic drug, was encapsulated in the emulsions with 99% loading efficiency and 6.4% loading capacity. The emulsions had long-term stability. The bioavailability and H22 tumor inhibition efficacy of PTX@BD/PRO were 40% and 70% higher than those of PTX@BD, respectively, after oral administration in the mice. More importantly, orally administrated PTX@BD/PRO had the same anti-tumor efficacy as intravenously injected commercial PTX injection. No abnormality was observed in the main organs of the mice after consecutive oral administration of PTX@BD/PRO. This study indicates that @BD/PRO is an excellent carrier of hydrophobic drugs/nutrients and is suitable for long-term oral administration.

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Section: Resultssupporting

confidence: 64%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protamine and BSA–dextran complex emulsion improves oral bioavailability and anti-tumor efficacy of paclitaxel

Bao

Yao

2020

Drug Delivery

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“…It was observed that the conjugates form a BSA film at the oil/water interface with the dextran shell, the latter acted as a steric barrier retaining the loaded curcumin by preventing its 443 diffusion into the aqueous phase, latter would have been facilitated by the carrier-acting ethanol 444 otherwise. At BSA concentration of 15 mg/mL in the aqueous phase, the curcumin loading efficiency was higher than 99% (Qi, et al, 2013;Wang, et al, 2016). Xu, Wang, & Yao (2017) used a similar oil mixture (90% MCT and 10% ethanol (v/v)) and observed similar behaviour for casein-soy soluble polysaccharide (CN/SSPS) conjugate-stabilized emulsions at pH 3-4.5, at this pH the protein and the polysaccharide carried opposite charges forming a rather integrated interfacial film via electrostatic interactions (Table 3).…”

mentioning

confidence: 93%

Recent advances in emulsion-based delivery approaches for curcumin: From encapsulation to bioaccessibility

Araiza‐Calahorra

Akhtar

Sarkar

2018

Trends in Food Science & Technology

357

162

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Background Curcumin has been widely acknowledged for its health-promoting effects. However, its application is often limited by its poor water solubility and biochemical/ structural degradation during physiological transit that restricts its bioavailability. Emulsion based approaches have attracted the most research attention to encapsulate curcumin and improve its stability, bioaccessibility and bioavailability. Scope and approach This review summarizes the recent advances in application of different oil-in-water emulsion-based approaches, such as, conventional emulsions (surfactants-, protein-and protein-polysaccharidestabilized emulsions), nanoemulsions, and Pickering emulsions that have been specifically used to deliver curcumin. Particular emphasis is given to factors affecting curcumin solubility, change in crystalline structure of curcumin upon dispersion and encapsulation efficiency. Changes in the droplet size and emulsion stability during in vitro oral-to-gastrointestinal digestion are discussed, with clear 34 focus on the bioaccessibility of the encapsulated curcumin. 35 36 Key findings and conclusions 37 Key factors that influence curcumin delivery include emulsion droplet size, oil composition, volume fraction, dispersion conditions of curcumin in the oil phase and the type of interfacial materials. Nanoemulsions have been the preferred choice for delivery of curcumin up to now. Although scarce in literature, emulsions stabilized by edible Pickering particles as shown by recent evidence are effective in protecting curcumin in an in vitro gastrointestinal setting due to their high coalescence stability. Further studies with emulsions stabilized by food-grade particles and accurate tracking of the physiological fate (in vitro to human trials) of different emulsion-based delivery vehicles are essential for rational designing of curcumin-rich functional foods with high bioaccessibility.

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Nanomedicine: Principles, properties, and regulatory issues

Mazahir

Bhogale

Palai

et al. 2023

Smart Polymeric Nano-Constructs in Drug Delivery

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Heat-Treated Emulsions with Cross-Linking Bovine Serum Albumin Interfacial Films and Different Dextran Surfaces: Effect of Paclitaxel Delivery

Cited by 13 publications

References 35 publications

Protamine and BSA–dextran complex emulsion improves oral bioavailability and anti-tumor efficacy of paclitaxel

Protamine and BSA–dextran complex emulsion improves oral bioavailability and anti-tumor efficacy of paclitaxel

Recent advances in emulsion-based delivery approaches for curcumin: From encapsulation to bioaccessibility

Nanomedicine: Principles, properties, and regulatory issues

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