Heavy metal and trace element concentrations in blood and follicular fluid affect ART outcome

Tolunay, Harun Egemen; Şükür, Yavuz Emre; Özkavukçu, Sinan; Seval, Mehmet Murat; Ateş, Can; Türksoy, Vugar Ali; Ecemiş, Tolga; Özmen, Batuhan; Berker, Bülent; Sönmezer, Murat

doi:10.1016/j.ejogrb.2016.01.001

Cited by 38 publications

(37 citation statements)

References 12 publications

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“…The successful rate of ART cycles can be affected by several internal as well as external factors (11,12). Oxidative stress is a state characterized by an imbalance between pro-oxidant molecules and antioxidant defenses and it plays a vital role in the pathogenesis of female infertility (13,14).…”

Section: Introductionmentioning

confidence: 99%

Melatonin Application in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis of Randomized Trials

Wang

et al. 2020

Front. Endocrinol.

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Objective: To study whether melatonin treatment can increase clinical pregnancy rate and live birth rate in assisted reproductive technology (ART) cycles. Methods: Literature searches were conducted to retrieve randomized trials that reported the effect of melatonin treatment on ART outcomes. Databases searched included PubMed, EMBASE, Cochrane Library, Web of Science, and Google Scholar. Results: Ten studies matched the inclusion criteria. Clinical pregnancy was reported in all of the included studies and live birth was reported in three studies. Melatonin treatment significantly increased the clinical pregnancy rate [OR = 1.43 (1.11, 1.86), power = 0.98, 10 RCTs, low-quality evidence] but not the live birth rate [OR = 1.38 (0.78, 2.46), power = 0.34, 3 RCTs, low-quality evidence]. Melatonin treatment increased the number of oocyte collected [SMD = 0.34 (0.01, 0.67), 7 RCTs, low-quality evidence], the number of maturated oocyte [SMD = 0.56 (0.27, 0.85), 7 RCTs, low-quality evidence], and the number of good quality embryo [MD = 0.36 (0.18, 0.55), 3 RCTs, low-quality evidence]. Melatonin treatment significantly increased the biochemical pregnancy rate [OR = 1.65 (1.14, 2.38), 6 RCTs, low-quality evidence] and had no significant effect on the miscarriage rate [OR = 1.28 (0.65, 2.51), 5 RCTs, low-quality evidence]. Conclusion: Melatonin treatment significantly increases the clinical pregnancy rate but not live birth rate in ART cycles. Melatonin treatment also increases the number of oocyte collected, maturated oocyte, and good quality embryo. No clear evidence suggested that melatonin treatment increased the adverse events in ART cycles. The actual findings may be compromised due to the wide heterogeneity of the included IVF patients, from PCOS to low ovarian reserve.

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Section: Introductionmentioning

confidence: 99%

Melatonin Application in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis of Randomized Trials

Wang

et al. 2020

Front. Endocrinol.

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“…Moreover, active smoking of the father is responsible for passive smoking for the mother (17) . Interestingly, heavy metals could enter the human body through respiratory system (6) . According to (18) , the level of exposure to metals in the smoke drawn from a single cigarette is small and likely not acutely toxic, but the accumulation of metals in the body over months, years, and decades of exposure is a health concern.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, passive and active smoking by women had been reported to be associated with delayed conception (31) . Although the CDC (28) reported that humans are exposed to toxic metals in trace concentrations through airborne pollution, and when presented in the blood or follicular fluid, they can have an effect on the reproductive health of women and consequently on the outcome of ICSI procedures (6) .…”

Section: Discussionmentioning

confidence: 99%

“…(5) Accumulation of heavy metals in the reproductive tissues of both women and men corroborates the likelihood of reproductive toxicity of heavy metals. (6) Likewise, an association had been reported between heavy metals (like As, Cd and Pb) and increased oxidative stress, cell apoptosis, endocrine disruption and epigenetic damage and through these mechanisms of toxicity, such elements could adversely affect outcomes of patients undergoing ICSI. (7) Follicular fluid is comprised of a blood plasma ultra-filtrate, with selective exclusion of high weight molecular proteins facilitated by the blood-follicle-barrier that fills the growing follicle and bathes a developing oocyte (8) .…”

Section: Introductionmentioning

confidence: 99%

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Effect of passive smoking on heavy metals concentration in blood and follicular fluid of patients on going ICSI

ElMohr¹,

Faris²,

Bakry³

et al. 2020

IJST

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Purpose: To assess the effects passive smoking and heavy metal concentrations in the blood and follicular fluid on assisted reproductive technology outcome.Methods: A prospective study was conducted between March 2017 and January 2018 in population consisted of 75 female patients undergoing an In vitro fertilization (IVF) cycle at Dr. Faris Medical center for Infertility and Human Reproduction located on Heliopolis, Cairo, Egypt; with unexplained infertility who underwent intracytoplasmic sperm injection (ICSI) using GnRH-antagonist protocol. Concentrations of three toxic metals Cadmium (Cd), Lead (Pb) and Arsenic (As) were measured both in blood sera and follicular fluid specimens. Patients were evaluated in two groups both undergoing ICSI; the first group consisted of patients who does not smoke or exposed to smoking (n=28) and the group passive smoker females (n=47). Results: These three heavy metals were significantly higher in serum and follicular fluid of passive smoking females (P<0.05). Also, higher concentrations of Cd, Pb and As were found in follicular fluid of passive smoking patients in comparison with non-smoker females. However, concentrations of Cd and Pb were not significantly different between both serum and follicular fluid. Conclusion: Passive smoking could affect levels of Cd, Pb and As in serum and follicular fluid of females undergoing Intra Cytoplasmic Sperm Injection (ICSI).

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“…[7][8][9][10][11][12][13][14][15][16][17][18] Three previous studies reported that Cu, Se, and/or Zn in FF were associated with improved pregnancy rates among study participants. [16][17][18] Conversely, toxic elements, especially Cd and Pb, in FF may adversely affect oocyte fertilization, 19 and lead to lower pregnancy rates. [10][11][12][13][14][15] Interestingly, some studies have suggested Cd levels in FF are associated with higher pregnancy rates among women undergoing IVF treatment.…”

Section: Introductionmentioning

confidence: 99%

Ultra-trace element analysis of human follicular fluid by ICP-MS/MS: pre-analytical challenges, contamination control, and matrix effects

Galusha

Haig

Bloom

et al. 2019

J. Anal. At. Spectrom.

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Heavy metal and trace element concentrations in blood and follicular fluid affect ART outcome

Cited by 38 publications

References 12 publications

Melatonin Application in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis of Randomized Trials

Melatonin Application in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis of Randomized Trials

Effect of passive smoking on heavy metals concentration in blood and follicular fluid of patients on going ICSI

Ultra-trace element analysis of human follicular fluid by ICP-MS/MS: pre-analytical challenges, contamination control, and matrix effects

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