Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction

Paithankar, Jagdish Gopal; Saini, Sanjay; Dwivedi, Shiwangi; Sharma, Anurag; Chowdhuri, D. Kar

doi:10.1016/j.chemosphere.2020.128350

Cited by 391 publications

(140 citation statements)

References 196 publications

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“…Heavy metals and metalloids are usually elements with a density higher than 5 g cm −3 (Tchounwou et al, 2012). Heavy elements displaying potential arrest on organisms growth, development, and productivity are classified as toxic heavy metals and metalloids (Järup, 2003;Clemens and Ma, 2016;Nguyen et al, 2021;Paithankar et al, 2021). The major threats to human health and the environment from heavy metals and metalloids are attributing to exposure to arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg; Järup, 2003).…”

Section: Introductionmentioning

confidence: 99%

Molecular Interaction and Evolution of Jasmonate Signaling With Transport and Detoxification of Heavy Metals and Metalloids in Plants

et al. 2021

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An increase in environmental pollution resulting from toxic heavy metals and metalloids [e.g., cadmium (Cd), arsenic (As), and lead (Pb)] causes serious health risks to humans and animals. Mitigation strategies need to be developed to reduce the accumulation of the toxic elements in plant-derived foods. Natural and genetically-engineered plants with hyper-tolerant and hyper-accumulating capacity of toxic minerals are valuable for phytoremediation. However, the molecular mechanisms of detoxification and accumulation in plants have only been demonstrated in very few plant species such as Arabidopsis and rice. Here, we review the physiological and molecular aspects of jasmonic acid and the jasmonate derivatives (JAs) in response to toxic heavy metals and metalloids. Jasmonates have been identified in, limiting the accumulation and enhancing the tolerance to the toxic elements, by coordinating the ion transport system, the activity of antioxidant enzymes, and the chelating capacity in plants. We also propose the potential involvement of Ca2+ signaling in the stress-induced production of jasmonates. Comparative transcriptomics analyses using the public datasets reveal the key gene families involved in the JA-responsive routes. Furthermore, we show that JAs may function as a fundamental phytohormone that protects plants from heavy metals and metalloids as demonstrated by the evolutionary conservation and diversity of these gene families in a large number of species of the major green plant lineages. Using ATP-Binding Cassette G (ABCG) transporter subfamily of six representative green plant species, we propose that JA transporters in Subgroup 4 of ABCGs may also have roles in heavy metal detoxification. Our paper may provide guidance toward the selection and development of suitable plant and crop species that are tolerant to toxic heavy metals and metalloids.

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Section: Introductionmentioning

confidence: 99%

Molecular Interaction and Evolution of Jasmonate Signaling With Transport and Detoxification of Heavy Metals and Metalloids in Plants

et al. 2021

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“…Cd-related liver and brain toxicity has been described in humans ingesting a diet containing 1 mg kg −1 (body weight)/day or 70 mg/day Cd, respectively [ 14 ]. Cadmium can also cause damage to the liver and brain, leading to high blood pressure and even cancer [ 14 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…As an abiotic stress factor, Cd can affect the growth and development of plants to varying degrees [ 14 ]. When Cd in the environment exceeds a certain concentration, it will stimulate oxidative stress in plants, induce lipid peroxidation, and increase the accumulation of reactive oxygen species (ROS), leading to oxidative damage [ 20 , 24 , 25 , 26 ]. In addition, Cd can also cause slower plant growth, decreased chlorophyll content, yellow leaves, and slower photosynthetic rate.…”

Section: Introductionmentioning

confidence: 99%

Research on the Mechanisms of Plant Enrichment and Detoxification of Cadmium

Yang

Zheng

Tan

et al. 2021

Biology

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The heavy metal cadmium (Cd), as one of the major environmentally toxic pollutants, has serious impacts on the growth, development, and physiological functions of plants and animals, leading to deterioration of environmental quality and threats to human health. Research on how plants absorb and transport Cd, as well as its enrichment and detoxification mechanisms, is of great significance to the development of phytoremediation technologies for ecological and environmental management. This article summarises the research progress on the enrichment of heavy metal cadmium in plants in recent years, including the uptake, transport, and accumulation of Cd in plants. The role of plant roots, compartmentalisation, chelation, antioxidation, stress, and osmotic adjustment in the process of plant Cd enrichment are discussed. Finally, problems are proposed to provide a more comprehensive theoretical basis for the further application of phytoremediation technology in the field of heavy metal pollution.

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“…Higher concentrations of HMs in agricultural soil account for many structural and physiological disorders that can affect the performance of many agricultural plants (Waheed et al, 2021). When consumed by humans, HMs exposed human cell to oxidative stress that lead to cardiovascular disease, developmental and neurological disorders, infertility, diabetes, and renal failure (Paithankar et al, 2021). The two most important resources; soil and water, which human's lives depend on are now the major carrier of HM contaminants.…”

Section: Introductionmentioning

confidence: 99%

Heavy Metals in Food Crops: Ideal Sources and Roles of Urban Agriculture in Facilitating Their Consumption- A Review

Abdullahi¹,

Igwe²,

Dandago³

et al. 2021

FJS

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The qualities of agricultural soil and water are diminishing continuously due to the rigorous anthropogenic activities currently stocking the soil with a lot of toxic chemicals including heavy metals. Heavy metals are highly persistent and non-biodegradable, control of their contamination is very tricky to handle. Their presence in soil and water is detrimental to food crops and humans. Various sources of heavy metals contaminants and the role of urban food production on human heavy metal contamination were discussed.Heavy metals have their way into the soil and food crops through wastewater irrigation and production in contaminated soil. The habitual heavy metals contamination sources for food crops are wastewater irrigation, abuse of agrochemicals, production in the contaminated field, atmospheric deposit when foods are exposed to contaminated air, and unethical mining activities. Agricultural soil in urban and peri-urban areas are heavily contaminated with heavy metal due to various anthropogenic activities. Wastewater irrigation intensify the contamination by supplying the soil with more heavy metals. The heavy metals are passed to food during production and subsequently to humans after consumption.

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Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction

Cited by 391 publications

References 196 publications

Molecular Interaction and Evolution of Jasmonate Signaling With Transport and Detoxification of Heavy Metals and Metalloids in Plants

Molecular Interaction and Evolution of Jasmonate Signaling With Transport and Detoxification of Heavy Metals and Metalloids in Plants

Research on the Mechanisms of Plant Enrichment and Detoxification of Cadmium

Heavy Metals in Food Crops: Ideal Sources and Roles of Urban Agriculture in Facilitating Their Consumption- A Review

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