Heavy metal blood concentrations in association with sociocultural characteristics, anthropometry and anemia among Kenyan adolescents

Ashley‐Martin, Jillian; Iannotti, Lora; Lesorogol, Carolyn; Hilton, Charles E.; Olungah, Charles Owuor; Zava, Theodore; Needham, Belinda L.; Cui, Yuhan; Brindle, Eleanor; Straight, Bilinda

doi:10.1080/09603123.2021.1929871

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…In recent years, mounting evidence from individual reports has revealed that TM exposure increases the risk of anemia (e.g. Ashley-Martin et al 2021 ; Bayhan et al 2017 ; Choi et al 2017 ; Lopez-Rodriguez et al 2017 ; Shen et al 2019 ; Yadav et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?

2022

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The kidney is the main organ that senses changes in systemic oxygen tension, but it is also the key detoxification, transit and excretion site of transition metals (TMs). Pivotal to oxygen sensing are prolyl-hydroxylases (PHDs), which hydroxylate specific residues in hypoxia-inducible factors (HIFs), key transcription factors that orchestrate responses to hypoxia, such as induction of erythropoietin (EPO). The essential TM ion Fe is a key component and regulator of the hypoxia–PHD–HIF–EPO (HPHE) signaling axis, which governs erythropoiesis, angiogenesis, anaerobic metabolism, adaptation, survival and proliferation, and hence cell and body homeostasis. However, inadequate concentrations of essential TMs or entry of non-essential TMs in organisms cause toxicity and disrupt health. Non-essential TMs are toxic because they enter cells and displace essential TMs by ionic and molecular mimicry, e. g. in metalloproteins. Here, we review the molecular mechanisms of HPHE interactions with TMs (Fe, Co, Ni, Cd, Cr, and Pt) as well as their implications in renal physiology, pathophysiology and toxicology. Some TMs, such as Fe and Co, may activate renal HPHE signaling, which may be beneficial under some circumstances, for example, by mitigating renal injuries from other causes, but may also promote pathologies, such as renal cancer development and metastasis. Yet some other TMs appear to disrupt renal HPHE signaling, contributing to the complex picture of TM (nephro-)toxicity. Strikingly, despite a wealth of literature on the topic, current knowledge lacks a deeper molecular understanding of TM interaction with HPHE signaling, in particular in the kidney. This precludes rationale preventive and therapeutic approaches to TM nephrotoxicity, although recently activators of HPHE signaling have become available for therapy.

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Section: Introductionmentioning

confidence: 99%

Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?

2022

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“…Some epidemiological studies have investigated the adverse effects of lead exposure during early periods of development on child growth. Some studies reported a negative association [ 21 , 22 , 23 , 24 , 25 ] between lead and child growth outcomes while other studies found no associations [ 26 , 27 , 28 , 29 , 30 ]. Existing evidence comes from studies that have been carried out in well-resourced countries, where regulations to control and eliminate lead are in place.…”

Section: Introductionmentioning

confidence: 99%

Lead Exposure in Infancy and Subsequent Growth in Beninese Children

Ahmadi

Botton

Zoumenou

et al. 2022

Toxics

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Studies suggest that elevated postnatal blood lead levels (BLLs) are negatively associated with child growth. This study aimed to investigate the associations of childhood BLLs at age one year and growth outcomes at age six years (n = 661) in a cohort of children in Allada, Benin. The growth outcomes studied are weight-for-age Z-score (WAZ), height-for-age Z-score (HAZ), BMI-for-age Z-score (BMIZ), weight-for-height Z-score (WHZ), head circumference (HC), growth velocities, underweight, stunting, and wasting. Multivariable regression models examined the associations between BLLs and growth outcomes, with adjustment for potential confounders. The geometric mean BLLs was 59.3 μg/L and 82% of children had BLLs >35 μg/L at the age of 12.8 months. After adjusting for confounding factors, no overall association was found between BLL quartiles and HAZ, WAZ, BMIZ, WHZ, growth velocities, wasting, and underweight. However, boys in the highest quartile had a 1.02 cm lower HC (95% CI: [−1.81, −0.24]) as compared to the lowest quartile. Furthermore, an increased odds of being stunted was observed in children in the highest quartile of exposure compared to the first (OR: 2.43; 95% CI: [1.11–5.33]) which remained statistically significant only among girls in sex-specific strata. Blood lead was found to be associated with an increased risk of childhood stunting and a lower head circumference in a resource-limited setting.

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“…Some epidemiological studies have investigated the adverse effects of lead exposure during early periods of development on child growth. Some studies reported a negative association [18][19][20][21][22] between lead and child growth outcomes, while other studies found no associations [23][24][25][26][27]. Existing evidence come from studies that have been carried out in well-resourced countries where regulations to control and eliminate lead are in place.…”

Section: Introductionmentioning

confidence: 99%

Lead Exposure in Infancy and Subsequent Childhood Growth

Ahmadi¹,

Botton²,

Zoumenou³

et al. 2022

Preprint

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Studies suggest that elevated postnatal blood lead levels (BLLs) are negatively associated with child growth. This study aimed to investigate associations of childhood BLLs at age one-year and growth outcomes at age six-years (n=661) in a cohort of children in Allada, Benin. The growth outcomes studied are weight-for-age Z-score (WAZ), height-for-age Z-score (HAZ) and BMI-for-age Z-score (BMIZ), head circumference (HC), underweight, stunting, and wasting. Multivariable regression models examined associations between blood lead levels, growth outcomes with adjustment for potential confounders. The geometric mean BLLs was 59.3 μg/L and 82% of children had BLLs &gt;35 μg/L at one year. After adjusting for confounding factors, no association was found between BLLs quartiles and HAZ, WAZ, BMIZ, and height and weight growth velocities. However, boys in the highest quartile had 1.02 cm lower HC (95% CI: [-1.81, -0. 24]) as compared to those in the lowest quartile with a dose-response trend across quartiles (Ptrend =0.02). Furthermore, an increased risk of being stunted was observed in children in the highest quartile of exposure compared to the first (OR: 2.43; 95% CI: [1.11 – 5.33]) with a dose-response trend (Ptrend =0.03). Blood lead was found to be associated with an increased risk of childhood stunting and lower head circumference in a resource-limited setting.

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Heavy metal blood concentrations in association with sociocultural characteristics, anthropometry and anemia among Kenyan adolescents

Cited by 7 publications

References 41 publications

Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?

Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?

Lead Exposure in Infancy and Subsequent Growth in Beninese Children

Lead Exposure in Infancy and Subsequent Childhood Growth

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