Heavy Metal Mediated Progressive Degeneration and Its Noxious Effects on Brain Microenvironment

Murumulla, Lokesh; Bandaru, Lakshmi Jaya Madhuri; Challa, Suresh

doi:10.1007/s12011-023-03778-x

Cited by 15 publications

(7 citation statements)

References 165 publications

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“…In today's rapidly industrializing and modernizing world, heavy metal pollution has emerged as a well-recognized public health concern that impacts daily life, including food, water sources, air quality, and occupational exposure [58,59]. Excessive intake of heavy metals can lead to neurotoxicity and subsequent neurological disorders [60][61][62]. As previously mentioned, astrocytes play a pivotal role in maintaining homeostasis in the central nervous system and safeguarding neurons against various types of harm caused by heavy metal accumulation [7,61].…”

Section: Link Between Reactive Astrocytes and Environmental Elementsmentioning

confidence: 99%

“…This vulnerability manifests through distributions in blood-brain barrier integrity, elevated levels of ROS, pro-inflammatory factors, impairment of mitochondrial respiration, and abnormalities in glutamate and lipid metabolism. These effects have been demonstrated through numerous experiments conducted both in vivo and in vitro [60][61][62][63][64][65][66][67]. For instance, Shi Fan et al's study [63] involved exposing rats to drinking water containing lead acetate (PbAc) for nine continuous weeks, which impaired learning memory and exploratory abilities.…”

Section: Link Between Reactive Astrocytes and Environmental Elementsmentioning

confidence: 99%

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The Diverse Roles of Reactive Astrocytes in the Pathogenesis of Amyotrophic Lateral Sclerosis

Yang,

Liu,

Zhang

2024

Brain Sciences

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Astrocytes displaying reactive phenotypes are characterized by their ability to remodel morphologically, molecularly, and functionally in response to pathological stimuli. This process results in the loss of their typical astrocyte functions and the acquisition of neurotoxic or neuroprotective roles. A growing body of research indicates that these reactive astrocytes play a pivotal role in the pathogenesis of amyotrophic lateral sclerosis (ALS), involving calcium homeostasis imbalance, mitochondrial dysfunction, abnormal lipid and lactate metabolism, glutamate excitotoxicity, etc. This review summarizes the characteristics of reactive astrocytes, their role in the pathogenesis of ALS, and recent advancements in astrocyte-targeting strategies.

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Section: Link Between Reactive Astrocytes and Environmental Elementsmentioning

confidence: 99%

Section: Link Between Reactive Astrocytes and Environmental Elementsmentioning

confidence: 99%

The Diverse Roles of Reactive Astrocytes in the Pathogenesis of Amyotrophic Lateral Sclerosis

Yang,

Liu,

Zhang

2024

Brain Sciences

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“…However, although in individuals who are non-occupationally exposed to copper, toxicity of this trace element is rather rare, exposure to high levels of copper from contaminated air, water, and food, can cause adverse effects in humans. An excess or toxicity of copper has been associated with hepatic disorders, neurodegenerative changes, as well as other diseases, which may occur when the homeostasis of copper is disrupted [47][48][49][50] . One of the most known human disorders related to copper is Wilson's disease.…”

Section: Copper Toxicity In Humansmentioning

confidence: 99%

A Literature Review of the Environmental and Health Risks of Copper Foil Manufacturing Plants in Relation to a New Facility Planned in Catalonia, Spain

Domingo

2024

j. of environ. & earth. sci.

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Electrolytic copper foil (electoral) is a thin copper foil with a thickness of less than 10 µm, which is an essential component for the manufacture of electric batteries. More specifically, it is widely used to make cathode collectors in rechargeable lithium batteries. Over the next few years, the expected demand for electricity is very important. Therefore, there will be an evident need for new manufacturing plants of copper foil. In relation to this, as can happen with any industrial facility, oil manufacturing plants may pose potential environmental and health risks. These risks may affect the surrounding ecosystems, as well as the population living in the vicinity of the facilities. Contamination of air (particulate matter, SO2, NOx, VOCs), water (copper and other heavy metals), and soil (heavy metals and other harmful substances) is an issue of notable concern. In Mont-Roig del Camp (Catalonia, Spain), a new electoral is currently planned. Considering the social concern that this facility—the first one in Spain—has raised in the population of the area, the state-of-the-art electrolytic copper foil manufacturing plants are here reviewed. The scientific databases Scopus, PubMed and Google Scholar, as well as information obtained from different sources (Internet), were used. The most important conclusion of this review is that there is currently no information—available in scientific journals—on the characterization and evaluation of the environmental and health risks of this kind of facility. Anyhow, to minimize the potential negative environmental and health impacts of this planned elecfoil manufacturing plant, strict periodical controls, comprehensive environmental management systems, and relevant regulations are strongly recommended.

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Section: Introductionmentioning

confidence: 99%

“…These processes interact and promote the development of neuroin ammation. Heavy metal ions can bind to neuronal proteins, causing neuronal damage, neuroin ammation, and nervous system dysfunction [11,12].Additionally, they can stimulate the immune system to produce an in ammatory response, resulting in neuroin ammation [13,14]. Heavy metal exposure promotes the production of reactive oxygen species (ROS), which can attack cell components and cause cell damage and in ammation [15, 16].…”

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confidence: 99%

Uncovering the Relationship between Heavy Metal Exposure, Cognitive Function, and Dietary Inflammation Index in Elderly Americans from the National Health and Nutrition Examination Survey 2011-2014

Tang,

Shen,

Hong

2024

Preprint

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Background The consequences of heavy metal exposure on cognitive function in elderly adults have been recognized as primarily attributed to the inflammatory response. It is noteworthy that diet can either exacerbate or reduce the inflammatory response. Despite this, there has been limited study about the effects of diet on the relationship between heavy metal exposure and cognitive function. Methods A cross-sectional study was conducted utilizing data from the 2011–2014 NHANES survey to explore the role of the dietary inflammation index in the association between metal exposure and cognitive function in elderly adults. The study enrolled 1726 participants and generalized linear regression model(GLM), Bayesian kernel machine regression model(BKMR), weighted quantile sum regression(WQS), and quantile g-computation regression analysis(Qg-comp) was conducted to assess the impact of five heavy metals in blood on cognitive function under the anti-inflammatory and pro-inflammatory diet. Results The GLM analysis showed a positive correlation between selenium (Se) and both the instant recall test (IRT) and digit symbol substitution test (DSST), whether taken as continuous or quartile variables.Conversely, cadmium (Cd) was negatively associated with DSST. For IRT, Cd in the highest quartile was negatively associated compared to the lowest quartile. Subgroup analysis revealed the effects of Cd on IRT and DSST and Se on DSST under the pro-inflammatory diet. Furthermore, The BKMR analysis showed an inverted U-shaped curve with the negative effect of metal mixtures and DSST and a linearly negative trend with IRT in the pro-inflammatory diet. Among them, Cd was emphasized as the most potent risk factor, and Se was the most vital protective factor for IRT and DSST in WQS and Qg-comp analysis. Conclusions The study suggests that a high-quality diet could alleviate the adverse effects of Cd on IRT and DSST. Additionally, high Se levels improved IRT and DSST in the inflammatory diet. These findings provide valuable insights into the connection between diet, heavy metal exposure, and cognitive function in elderly adults.

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Heavy Metal Mediated Progressive Degeneration and Its Noxious Effects on Brain Microenvironment

Cited by 15 publications

References 165 publications

The Diverse Roles of Reactive Astrocytes in the Pathogenesis of Amyotrophic Lateral Sclerosis

The Diverse Roles of Reactive Astrocytes in the Pathogenesis of Amyotrophic Lateral Sclerosis

A Literature Review of the Environmental and Health Risks of Copper Foil Manufacturing Plants in Relation to a New Facility Planned in Catalonia, Spain

Uncovering the Relationship between Heavy Metal Exposure, Cognitive Function, and Dietary Inflammation Index in Elderly Americans from the National Health and Nutrition Examination Survey 2011-2014

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