Heavy metal poisoning: management of intoxication and antidotes

Rusyniak, Daniel E.; Arroyo, Anna Maria; Acciani, Jennifer; Froberg, Blake; Kao, Louise; Furbee, Brent

doi:10.1007/978-3-7643-8338-1_11

Cited by 34 publications

(29 citation statements)

References 184 publications

(228 reference statements)

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“…Essential elements toxicity occurs when concentrations are either too low or too high. For other elements, such as arsenic, mercury, lead and thallium, there are no physiological concentrations that are beneficial, and these elements only have the potential to cause toxicity (Rusyniak et al 2010). For instance, several toxic elements have been associated with impaired human semen quality and sperm DNA integrity at relatively low levels .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Seasonal Variability of Toxic and Essential Elements in Urine Analyzed by Inductively Coupled Plasma Mass Spectrometry

et al. 2016

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Human exposure to elements is a process difficult to control and monitor. Studies on this topic usually rely on single spot urine sample to assess exposure, with the risk of ignoring variability over a longer period. In this work, we measured the urinary excretion of toxic and essential elements during 1 year with the overall goal of exploring the variability caused by seasonality on their concentration. Seven participants were recruited, and first morning urines were collected three times for each season, during November, January, April and July. Participants followed the same balanced diet during the week of collection. We then monitored nineteen essential and toxic elements in urines by inductively coupled plasma mass spectrometry. Unsupervised multivariate statistical analysis separated samples collected during summer from the ones collected during other seasons. Twelve elements had a significant seasonal variation (ANOVA test, p \ 0.05) and their levels resulted increased during summer. These elements were both contaminants, such as Ni, Hg, Cd and Tl, and essential elements such as Se and Cu. However, none of these elements was detected at toxic concentration. In this study, we point out for the first time the variability of urine element concentration due to seasonality and we propose that the season of collection should be considered when providing urinary reference values of elements.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Seasonal Variability of Toxic and Essential Elements in Urine Analyzed by Inductively Coupled Plasma Mass Spectrometry

et al. 2016

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“…Extended exposure to these elements causes their retention and internal imbalances within the body, which consequently starts using them as substitutes for essential elements; Pb can substitute for calcium (Ca), Cd readily substitutes for Zn, and aluminum (Al) may substitute for almost all trace elements (Weber and Konieczyński 2003). HMs accumulated in tissues disrupt a vast array of metabolic processes by altering the pro-oxidant/antioxidant balance (bind to free sulfhydryl groups resulting in inhibition of glutathione metabolism) and interfering with the activity and function of several enzymes and hormones (Rusyniak et al 2010). In turn, disruption of the metabolism of carbohydrates, proteins, amino acids, lipids, neurotransmitters, and hormones increases susceptibility to infections; adversely affects the central nervous system, memory, and reproductive system; and results in mutagenesis, toxicity to skin, bones and teeth, kidney damage, and liver dysfunction (Mukke and Chinte 2012).…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of heavy metals in medicinal plants collected from environmentally diverse locations in India for use in a novel phytopharmaceutical product

Sadhu

Upadhyay

Singh

et al. 2015

Environ Monit Assess

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It is important to monitor the quality of the phytopharmaceutical product as its therapeutic potential depends on standardized delivery of active ingredients present in the botanical source. Minimal presence of toxic impurities like heavy metals (HMs) is warranted to ensure product safety and prevent hazardous health impacts. In the present study, conducted as part of the development of a novel phytopharmaceutical product, the chemical profile of 13 heavy metals (Fe, Cu, Mn, Zn, Ni, Co, Mo, V, Cr, As, Pb, Hg, and Cd) was studied in the whole plant, fruit, and rhizome of Bacopa monnieri, Hippophae rhamnoides, and Dioscorea bulbifera, respectively, from environmentally diverse regions in India. Most samples had HM profiles within permissible limits as established by regulatory authorities, with the exception of Cd and Hg in low-altitude regions. This study indicates geographical regions in India suitable for procuring raw materials to develop and manufacture phytopharmaceutical products.

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“…The main demerit of LucFF is, unlike fluorescent reporter proteins, it does not allow to develop live cell assays and is restricted to a single data point in each experiment. 20 The automation is hindered because of the step required for the addition of substrate for the LucFF assay. Moreover, the signal associated with luminescence measurement is transient, and it is very critical to measure just after the addition of the substrate.…”

Section: Discussionmentioning

confidence: 99%

Development of a Cell-Free Optical Biosensor for Detection of a Broad Range of Mercury Contaminants in Water: A Plasmid DNA-Based Approach

et al. 2019

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Mercury (Hg) is one of the main water contaminants worldwide. In this study, we have developed both whole-cell and cell-free biosensors to detect Hg. Genetically modified plasmids containing the merR gene were used to design biosensors. Firefly luciferase (LucFF) and emerald green fluorescent protein (EmGFP) genes were separately introduced as a reporter. Both constructs showed a detection limit of 1 ppb (Hg) in Escherichia coli and the cell-free system. We found that higher concentrations of Hg become detrimental to bacteria. This cytotoxic effect shows an anomalous result in high Hg concentrations. This was also observed in the cell-free system. We found that EmGFP fluorescence was decreased in the cell-free system because of a change in pH and quenching effect by Hg excess. Once the pH was adjusted to 7 and a chelating agent was used, the EmGFP fluorescence was partially restored. These adjustments can only be done in the cell-free system after the GFP expression and not in whole cells where their number has been decreased because of toxicity. Therefore, we suggest the use of the cell-free-system, which not only reduces the total experimental time but also allows us to perform these postexperimental adjustments to achieve higher sensitivity. We would also recommend to perform more measurements at a time with different dilution factors to bring down the Hg concentration within the measurable limits or to use some other chelating agents which can further reduce the excess Hg concentration.

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Heavy metal poisoning: management of intoxication and antidotes

Cited by 34 publications

References 184 publications

Evaluation of Seasonal Variability of Toxic and Essential Elements in Urine Analyzed by Inductively Coupled Plasma Mass Spectrometry

Evaluation of Seasonal Variability of Toxic and Essential Elements in Urine Analyzed by Inductively Coupled Plasma Mass Spectrometry

Quantitative analysis of heavy metals in medicinal plants collected from environmentally diverse locations in India for use in a novel phytopharmaceutical product

Development of a Cell-Free Optical Biosensor for Detection of a Broad Range of Mercury Contaminants in Water: A Plasmid DNA-Based Approach

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