In typical semi-arid areas, the timely and effective monitoring and evaluation of soil heavy metal pollution are of critical importance to prevent soil deterioration and achieve the sustainable use of soil resources. To further understand the degree of soil heavy metal pollution in different functional areas, we studied the soil heavy metal pollution on the northern slope of the eastern Tianshan Mountains in Xinjiang. We collected 104 surface soil samples from typical commercial (A), industrial (B), and agricultural (C) areas with different land-use patterns. The contents of Zn, Cu, Cr, Pb, As, and Hg in the soil of different functional areas were evaluated using the geo-accumulation index, the single-factor pollution index, and potential ecological risk. The results showed that the contents of Pb, As, and Hg in soils of different functional areas exceeded 4.47, 8.03, and 1.5 times the background values of Xinjiang soil, respectively. The average contents of Zn, Cu, and Cr were lower than the background values of Xinjiang soil. Except for As in different functional areas, the contents of the other elements in the different functional areas reached the level of soil environmental quality standards in China (GB15618-2018). The geo-accumulation index of heavy metals in different functional areas was in the order of Area C > Area A > Area B, indicating that Area C was the most polluted. The results of the single-factor pollution index showed that the pollution levels of Pb, As, and Hg were higher, and the pollution levels of Cr, Cu, and Zn were lower. The results of the potential ecological risk index showed that the northwest of Area A was higher, the southeast of Area B was more polluted, and the central and eastern parts of Area C were more polluted. From the perspective of spatial distribution, the spatial distribution characteristics of Zn and Cr elements in different functional areas are consistent, but the spatial distribution characteristics of Cu, Pb, As, and Hg in different functional areas are quite different. The high values of these four elements are mainly distributed in residential areas, factories, and metal smelters. It is necessary to divide the functional areas based on different land-use patterns, and the prevention of soil single-element and heavy metal pollution in different functional areas is reasonable for land resources and provides a scientific basis for the effective planning of quality assurance.