Heavy metal toxicity: An update of chelating therapeutic strategies

Kim, Jong-Joo; Kim, You-Sam; Kumar, Vijay

doi:10.1016/j.jtemb.2019.05.003

Cited by 444 publications

(252 citation statements)

References 89 publications

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“…Heavy metals can accumulate in the food chain and cause major human health problems if not managed and treated properly. Kim et al classified heavy metals into two groups based on their toxicity: essential and non-essential heavy metals [1]. Essential heavy metals including Cu, Fe, Co, and Zn are relatively less toxic at low concentration levels.…”

Section: Introductionmentioning

confidence: 99%

“…Heavy metals severely affect the human nervous system and can cause headache, hypertension, fatigue, anaemia, and even cancer [3,4]. Lead and Cu(II) are listed on the United States Environmental Protection Agency (USEPA) priority control pollutants list due to their persistence and irreversible toxic characteristics [1]. Rapid industrialisation increases the levels of heavy metal contamination in the environment [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Optimisation and Modelling of Pb(II) and Cu(II) Biosorption onto Red Algae (Gracilaria changii) by Using Response Surface Methodology

Isam

Baloo

Kutty

et al. 2019

Water

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The removal of Pb (II) and Cu (II) ions by using marine red macroalgae (Gracilaria changii) as a biosorbent material was evaluated through the batch equilibrium technique. The effect of solution pH on the removal of metal ions was investigated within the range of 2–7. The response surface methodology (RSM) technique involving central composite design (CCD) was utilised to optimise the three main sorption parameters, namely initial metal ion concentration, contact time, and biosorbent dosage, to achieve maximum ion removal. The models’ adequacy of response was verified by ANOVA. The optimum conditions for removal of Pb (II) and Cu (II) were as follows: pH values of 4.5 and 5, initial concentrations of 40 mg/L, contact times of 115 and 45 min, and biosorbent dosage of 1 g/L, at which the maximum removal percentages were 96.3% and 44.77%, respectively. The results of the adsorption isotherm study showed that the data fitted well with the Langmuir’s model for Pb (II) and Cu (II). The results of the adsorption kinetic study showed that the data fitted well with the pseudo-second order model for Pb (II) and Cu (II). In conclusion, red alga biomass exhibits great potential as an efficient low-cost sorbent for removal of metal ions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optimisation and Modelling of Pb(II) and Cu(II) Biosorption onto Red Algae (Gracilaria changii) by Using Response Surface Methodology

Isam

Baloo

Kutty

et al. 2019

Water

View full text Add to dashboard Cite

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“…Essential heavy metals homeostasis is wisely regulated through protein transporters responsible for their uptake, distribution, storage, and excretion. Metal accumulation in the human body leads to damage to many organs, especially the nervous, respiratory, and reproductive systems [45]. In fact, metal accumulation induces ROS production, which results in membrane lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Antioxidant Potential of Seaweed Extracts for Enrichment of Convenience Food

et al. 2020

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In recent years, there has been a growing interest in natural antioxidants as replacements of synthetic compounds because of increased safety concerns and worldwide trend toward the usage of natural additives in foods. One of the richest sources of natural antioxidants, nowadays largely studied for their potential to decrease the risk of diseases and to improve oxidative stability of food products, are edible brown seaweeds. Nevertheless, their antioxidant mechanisms are slightly evaluated and discussed. The aims of this study were to suggest possible mechanism(s) of Fucus vesiculosus antioxidant action and to assess its bioactivity during the production of enriched rye snacks. Chemical and cell-based assays indicate that the efficient preventive antioxidant action of Fucus vesiculosus extracts is likely due to not only the high polyphenol content, but also their good Fe 2+ -chelating ability. Moreover, the data collected during the production of Fucus vesiculosus-enriched rye snacks show that this seaweed can increase, in appreciable measure, the antioxidant potential of enriched convenience cereals. This information can be used to design functional foods enriched in natural antioxidant ingredients in order to improve the health of targeted consumers.

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“…In another study, it was observed that dietary supplementation with a galactooligosaccharide produced an increase in fecal excretion of lead, a decrease in plasma and tissue concentration of the metal in mice. This effect was not observed when the microbiota of the mice was modified with antibiotics [39]. On the other hand, the probiotic strain Lactobacillus plantarum CCFM8661, prevented the absorption of lead in mice by intestinal sequestration, also significantly induced bile acid synthesis, improved bile flow and bile glutathione excretion, and increased bile acid excretion in feces of mice, the outflow of bile lead and improved fecal excretion of lead.…”

Section: Toxicokinetics and Heavy Metal Toxicodynamicsmentioning

confidence: 95%

Role of the Microbiome as the First Metal Detoxification Mechanism

Monroy-Torres¹,

Hernández-Luna²,

Ramírez-Gómez³

et al. 2020

Prebiotics and Probiotics - Potential Benefits in Nutrition and Health

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Exposure to environmental toxins in water, soil and air are increasing with health effects, mainly in older ages and physiological states (childhood and pregnancy). The role of the microbiota has been widely studied with effects on the maintenance of health but this is only possible with a diet that promotes it. The traditional Mexican diet is rich in fiber, which has prebiotic effects and has found a higher excretion of arsenic and fluoride in adolescents who maintained a diet high in fiber derived from traditional foods. After several descriptive studies in the state of Guanajuato, since 2004, first with arsenic in drinking water in population of several communities, in 2015, it is achieved through an intervention study with a supplementation of several vitamins and minerals in population adolescent, a greater urinary arsenic and fluoride excretion, as well as a greater consumption of traditional foods such as beans, bananas, orange and quelites. Food is key to maintain a function of the microbiota, so its review and study should be encouraged.

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Heavy metal toxicity: An update of chelating therapeutic strategies

Cited by 444 publications

References 89 publications

Optimisation and Modelling of Pb(II) and Cu(II) Biosorption onto Red Algae (Gracilaria changii) by Using Response Surface Methodology

Optimisation and Modelling of Pb(II) and Cu(II) Biosorption onto Red Algae (Gracilaria changii) by Using Response Surface Methodology

Characterization of Antioxidant Potential of Seaweed Extracts for Enrichment of Convenience Food

Role of the Microbiome as the First Metal Detoxification Mechanism

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