Heavy metals accumulation and endocrine disruption in Prochilodus argenteus from a polluted neotropical river

Paschoalini, Alessandro Loureiro; Savassi, Lourenço Almeida; Arantes, Fábio Pereira; Rizzo, Elizete; Bazzoli, Nilo

doi:10.1016/j.ecoenv.2018.11.047

Cited by 63 publications

(29 citation statements)

References 101 publications

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“…Although several studies focused on the ability of heavy metals and POPs to alter the functionality of the endocrine system (Beszterda & Franski, 2018;Buha et al, 2018;Kranthi Kumar, Uma Devi, & Neeraja, 2018;Paschoalini, Savassi, Arantes, Rizzo, & Bazzoli, 2019;Saxena, Purchase, Mulla, Saratale, & Bharagava, 2020), their involvement in cancer development is also increasingly emerging (Cao, Fan, Li, & Xiao, 2019;Leng et al, 2016;Rehman, Fatima, Waheed, & Akash, 2018).…”

Section: Introductionmentioning

confidence: 99%

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Forte

Indovina

Costa

et al. 2019

Journal Cellular Physiology

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In Italy, in the eastern area of the Campania region, the illegal dumping and burning of waste have been documented, which could potentially affect the local population's health. In particular, toxic waste exposure has been suggested to associate with increased cancer development/mortality in these areas, although a causal link has not yet been established. In this pilot study, we evaluated blood levels of toxic heavy metals and persistent organic pollutants (POPs) in 95 patients with different cancer types residing in this area and in 27 healthy individuals. While we did not find any significant correlation between the blood levels of POPs and the provenance of the patients, we did observe high blood concentrations of heavy metals in some municipalities, including Giugliano, where many illegal waste disposal sites have previously been documented. Our results showed that patients with different cancer types from Giugliano had higher blood levels of heavy metals than healthy controls. Despite the obvious limitations of this exploratory study, our preliminary observations encourage further research assessing the possible association between exposure to hazardous waste, increased blood metals, and increased risk of cancer.

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Section: Introductionmentioning

confidence: 99%

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Forte

Indovina

Costa

et al. 2019

Journal Cellular Physiology

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“…Therefore, the histopathological alterations noted in the fish tissues in this study, are the effect of pollutants at the histological level. Liver histopathology and macrophage aggregates which have been used by the United States National Marine Fisheries Services, is being proposed by the WHO-FAO to be included in monitoring programmes in other countries [17,18]. The changes in the liver observed in this study such as inflammation, nuclear abnormality, irregular shaped hepatocytes, and increased nuclear vacuolation have been associated with fish exposed to hydrocarbons [19, 20, 21].…”

Section: Fig 6 -Histology Of Liver Of the African Catfish (Clarias Gmentioning

confidence: 94%

Histopathological Biomarkers of Exposure to Monocyclic Aromatic Hydrocarbons in Clarias Ggariepinus (African Catfish)

Doherty

Adeola

Aneyo

et al. 2019

JST

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“…Human exposure to heavy metals has increased significantly in the last decades as a result of a parallel increment in the use of these metals in industrial processes [ 1 ] and products [ 2 , 3 ]. Therefore, considerable attention has been focused on environmental pollution and the biological effects of these elements [ 4 , 5 ], including mercury (Hg) [ 6 ]. Hg contamination is extensive in all environmental compartments such as soil, air and water [ 7 , 8 ] and human exposure to Hg has increased with modern industrialization due to its anthropogenic emissions from fuel combustion, municipal incinerators and chemical industries.…”

Section: Introductionmentioning

confidence: 99%

Novel Insights into Mercury Effects on Hemoglobin and Membrane Proteins in Human Erythrocytes

et al. 2020

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Mercury (Hg) is a global environmental pollutant that affects human and ecosystem health. With the aim of exploring the Hg-induced protein modifications, intact human erythrocytes were exposed to HgCl2 (1–60 µM) and cytosolic and membrane proteins were analyzed by SDS-PAGE and AU-PAGE. A spectrofluorimetric assay for quantification of Reactive Oxygen Species (ROS) generation was also performed. Hg2+ exposure induces alterations in the electrophoretic profile of cytosolic proteins with a significant decrease in the intensity of the hemoglobin monomer, associated with the appearance of a 64 kDa band, identified as a mercurized tetrameric form. This protein decreases with increasing HgCl2 concentrations and Hg-induced ROS formation. Moreover, it appears resistant to urea denaturation and it is only partially dissociated by exposure to dithiothreitol, likely due to additional protein–Hg interactions involved in aggregate formation. In addition, specific membrane proteins, including band 3 and cytoskeletal proteins 4.1 and 4.2, are affected by Hg2+-treatment. The findings reported provide new insights into the Hg-induced possible detrimental effects on erythrocyte physiology, mainly related to alterations in the oxygen binding capacity of hemoglobin as well as decreases in band 3-mediated anion exchange. Finally, modifications of cytoskeletal proteins 4.1 and 4.2 could contribute to the previously reported alteration in cell morphology.

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Heavy metals accumulation and endocrine disruption in Prochilodus argenteus from a polluted neotropical river

Cited by 63 publications

References 101 publications

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Histopathological Biomarkers of Exposure to Monocyclic Aromatic Hydrocarbons in Clarias Ggariepinus (African Catfish)

Novel Insights into Mercury Effects on Hemoglobin and Membrane Proteins in Human Erythrocytes

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