Heavy metals and pesticides in chronic kidney disease – Results from a matched case–control study from a rural population in Shivamogga district in South India

Anupama, YJ; Kıran, Sibel; Hegde, ShrikanthN

doi:10.4103/ijn.ijn_325_18

Cited by 18 publications

(8 citation statements)

References 38 publications

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“…The results of the present study are in accordance to with the epidemiological studies conducted to find an association between CKD and exposure to heavy metals [38,1] but these results are not in compliance with the studies conducted in India [39].…”

Section: Fig 1 Shows the Mechanism Of Increasing Creatinine Level In Bloodsupporting

confidence: 70%

Effect of Heavy Metals on Creatinine Level in Human Blood Samples of Inhabitants Living in the Vicinity of Hudiara Drain, Lahore, Pakistan

Jadoon

Sharif

Ali

et al. 2021

JPRI

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Aims: Modern industrialization, anthropogenic and industrial activities have increased the risk of human exposure to heavy metals and in turn effecting human health badly. Hundreds of millions of people are globally affected by heavy metal toxicity through contaminated water in one way or. another. In order to find a correlation between the heavy metal concentrations and serum creatinine level, a study was conducted on the inhabitants living near the Hudiara drain suffering from kidney diseases. Study Design: The subjects (n=498) were selected from the vicinity of polluted Hudiara drain to conduct this matched case–control study in 2019-2020. Instrumental techniques were used for the determination of heavy metals and creatinine was determined by using Kit. The correlation between heavy metals and creatinine was checked. Place and Duration of Study: To determine heavy metals and creatinine in blood, samples were collected from the habitants of Hudiara drain and the control group 100Km far from Hudiara drain. Methodology: Blood samples of male subjects with and tested for heavy metals in the blood using atomic absorption spectrophotometer and creatinine level using Creatinine Elisa Kit. The study was conducted in 2020 and included n= 498 healthy volunteers (control) and n=498 effected (suffering from chronic kidney disease). Results: The ANOVA shows the significant difference between two groups i.e. control group and affected group in all traits of the respondents (weight, age, heavy metal values and serum creatinine level). Pearson’s correlation coefficient was calculated for heavy metals and creatinine subjects’ blood samples. It was found that heavy metal levels in subjects have a significant correlation with serum creatinine. The study shows that serum creatinine level has no significant correlation with age, so is independent of age. Conclusion: The concentration of heavy metal contaminants (Cd, Hg, Pb) in the blood of the inhabitants of Hudiara drain flowing in Lahore city, Pakistan is highly polluted by industrial effluents. The effects of higher concentration of heavy metals in the inhabitants of Hudiara drain have been determined in serum creatinine levels. It was observed that high serum creatinine values are found in subjects suffering from CKD.

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Section: Fig 1 Shows the Mechanism Of Increasing Creatinine Level In Bloodsupporting

confidence: 70%

Effect of Heavy Metals on Creatinine Level in Human Blood Samples of Inhabitants Living in the Vicinity of Hudiara Drain, Lahore, Pakistan

Jadoon

Sharif

Ali

et al. 2021

JPRI

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“… 50 , 51 Although some association of heavy metals have been made with increased risk of CKDu, such findings have been inconsistent. 23 , 24 Thus, it is unsurprising that elemental analysis found that urinary levels of heavy metals were relatively low and did not increase significantly over the harvest. 40 , 41 , 42 , 43 It is important to emphasize that the agricultural company where these workers were employed had implemented a program to reduce worker exposure to heavy metal contaminated water through routine QC testing for metals in their supplied drinking water.…”

Section: Discussionmentioning

confidence: 99%

“…Current literature has yet to demonstrate a conclusive link, with many studies providing contradictory results and meta-analyses not finding any statistically significant risks. 19 , 20 , 21 , 22 , 23 , 24 A more recent hypothesis centers on a putative role for silica nanoparticles. Sugarcane stalks are comprised primarily of naturally occurring amorphous silica, which can be released during routine crop burning.…”

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confidence: 99%

Exposome and Metabolome Analysis of Sugarcane Workers Reveals Predictors of Kidney Injury

Stem,

Brindley,

Rogers

et al. 2024

Kidney International Reports

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“…Similarly, Diyabalanage et al found no evidence of heavy metal toxicity in hair and nails of CKDu patients, compared to controls [73]. A study from the Shivamogga district of South India also did not find an association between the blood and urine levels of heavy metals and CKD [74].…”

Section: Methodsmentioning

confidence: 99%

Chronic kidney disease of unknown aetiology: A comprehensive review of a global public health problem

Rao,

Bangera,

Nagaraju

et al. 2023

Tropical Med Int Health

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The term chronic kidney disease of unknown aetiology (CKDu) refers to chronic kidney disease (CKD) in the absence of diabetes, long-standing hypertension, glomerulonephritis, obstructive uropathy or other apparent causes. An increasing number of CKDu cases have been reported from Latin America, Sri Lanka, India and others over the last two decades. These regional nephropathies share the following common attributes: (a) they affect low-to-middle income countries with tropical climates, (b) involve predominantly rural agricultural communities, (c) male predilection, (d) absence of significant proteinuria and hypertension, and (e) chronic tubulointerstitial nephritis on kidney biopsy. The current body of literature suggests that CKDu may be caused by heat stress, agrochemicals, contaminated drinking water or heavy metals; however, considerable regional disparities in CKDu research make it difficult to establish a common causal link. In the absence of a definite aetiology, specific preventive and therapeutic interventions are lacking. Improvement of working conditions of farmers and labourers, provision of safe drinking water and changes in agricultural practices are some of the measures that have been implemented; however, there is lack of data to assess their impact on the incidence and progression of CKDu. There is a need for a concerted global effort to address the current knowledge gaps, and to develop effective and sustainable strategies to tackle this devastating disease.K E Y W O R D S agrochemicals, chronic kidney disease of uncertain aetiology, chronic renal insufficiency, endemic nephropathy, epidemiology, groundwater, interstitial nephritis, public health measures, risk factors Indu Ramachandra Rao and Ashika Bangera contributed equally to this work.

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Heavy metals and pesticides in chronic kidney disease – Results from a matched case–control study from a rural population in Shivamogga district in South India

Cited by 18 publications

References 38 publications

Effect of Heavy Metals on Creatinine Level in Human Blood Samples of Inhabitants Living in the Vicinity of Hudiara Drain, Lahore, Pakistan

Effect of Heavy Metals on Creatinine Level in Human Blood Samples of Inhabitants Living in the Vicinity of Hudiara Drain, Lahore, Pakistan

Exposome and Metabolome Analysis of Sugarcane Workers Reveals Predictors of Kidney Injury

Chronic kidney disease of unknown aetiology: A comprehensive review of a global public health problem

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