Heavy metals exposure is associated with early liver dysfunction among rural residents aged 40–75 years in southwest China

Yang, Zhao; Li, Xiaomeng; Tian, Lin; Song, Yang; Zhang, Yu; Chen, Jinyao; Zhang, Lishi

doi:10.1002/jat.4276

Cited by 16 publications

(4 citation statements)

References 44 publications

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“…The liver is one of the main target organs of arsenic poisoning [ 6 ]. Previous studies have shown that chronic arsenic exposure can cause liver injury, hepatitis, liver fibrosis, cirrhosis, liver cancer, and other related malignant diseases [ 7 , 8 ]. Population epidemiological investigations and experimental studies have confirmed that arsenic can cause liver damage.…”

Section: Introductionmentioning

confidence: 99%

The Molecular Mechanism of Hepatic Lipid Metabolism Disorder Caused by NaAsO2 through Regulating the ERK/PPAR Signaling Pathway

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Chronic arsenic exposure is a risk factor for human fatty liver disease, and the ERK signaling pathway plays an important role in the regulation of liver lipid metabolism. However, whether ERK plays a role in the progression of arsenic-induced liver lipid metabolism disorder and the specific mechanism remain unclear. Here, by constructing a rat model of liver lipid metabolism disorder induced by chronic arsenic exposure, we demonstrated that ERK might regulate arsenic-induced liver lipid metabolism disorders through the PPAR signaling pathway. Arsenic could upregulate the expression of PPARγ and CD36 in the rat liver, decrease the expression of PPARα and CPT-1 in the rat liver, increase the organ coefficient of the rat liver, decrease the content of TG in rat serum, and promote fat deposition in the rat liver. In the arsenic-induced rat model of hepatic lipid metabolism disorder, we found that the expression of p-ERK was increased. In order to further explore whether the ERK signaling pathway was involved in arsenic-induced liver lipid metabolism disorder, we exposed L-02 cells to different arsenic concentrations, and the results showed that arsenic significantly increased the expression of P-ERK in L-02 cells in a dose-dependent manner. We further treated L-02 cells with ERK inhibitors and found that the expression of TG, PPARα, and CPT-1 in L-02 cells increased, while the expression of P-ERK, PPARγ, and CD36 decreased. In conclusion, ERK may be involved in arsenic-induced liver lipid metabolism disorder by regulating the PPAR signaling pathway. These findings are expected to provide a new targeting strategy for arsenic-induced liver lipid metabolism disorder.

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Section: Introductionmentioning

confidence: 99%

The Molecular Mechanism of Hepatic Lipid Metabolism Disorder Caused by NaAsO2 through Regulating the ERK/PPAR Signaling Pathway

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Due to their persistent nature, high toxicity, bioavailability in the open environment, and the potential for greater bioaccumulation and biomagnification have posed severe health risks to humans, animals, and plants [7]. For instance, lead (Pb) can adversely affect the human central nervous system (CNS); can cause abdominal pain, irritability, sleeplessness, and headache; and can cause behavioral abnormalities and learning issues in children under the age of five due to higher susceptibility [8]. A higher concentration of zinc (Zn) may cause infertility, CNS disorder, and kidney disease.…”

Section: Introductionmentioning

confidence: 99%

“…These multiple route exposu (inhalation, dermal absorption, and direct ingestion) data are necessary to thoroughly sess the dumpsite's deleterious impacts on human health. Moreover, the contaminati of the soil-plant continuum with heavy metals such as Cr, Ni, Fe, Pb, and Zn has also be in focus in recent studies [7][8][9][10][11][12]. Taking these problems into consideration and to find o a sustainable solution in the form of screening various plant species to act as hyperacc mulators for different heavy metals, the current study was conducted to screen hyper cumulator plants growing around the solid waste dumpsite of Peshawar and to ass HM concentrations in the dumpsite's soil and plants and their associated risks to hum health.…”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation of Heavy Metals in a Soil–Plant System from an Open Dumpsite and the Associated Health Risks through Multiple Routes

et al. 2022

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Screening various plant species to act as hyperaccumulators and associated health risks could serve as a sustainable solution for the bioremediation heavy metals (HMs). For the first time, the present study explored the phytoremediation potential of native plants, soil enrichment, and human health risks associated with the contamination of HMs in soil and plant samples collected from a municipal solid-waste open dump site. Soil and plant samples (n = 18 + 18) from the dumpsite and (n = 18) from the control site were analyzed for selected HMs, i.e., Chromium (Cr), Lead (Pb), Nickel (Ni), Iron (Fe), and Zinc (Zn). The phytoremediation potential of plants was assessed using the bioaccumulation factor (BAF), bioaccumulation coefficient (BAC), and translocation factor (TF), while soil pollution levels were evaluated using the contamination factor (CF), geoaccumulation index (Igeo), enrichment factor (EF), potential ecological risk index (PERI), and human health risk indices. The results revealed that based on TF and BAC values, Alhagi maurorum Medic., Astragalus creticus Lam., Cichorium intybus L., Berberis lycium Royle, and Datura stramonium L. were hyperaccumulators for Cr while Parthenium hysterophorus L. was a promising species for both Ni and Cr. Similarly, CF values for Fe, Ni, Pb, and Cr were >6, thereby showing very high contamination, while Igeo values for Fe, Ni, Pb, and Cr were (class 6, >5), showing that the soil was extremely polluted. Furthermore, EF values for Fe, Ni, Pb, Cr, and Zn were 2 < EF ≤ 5, depicting moderate enrichment, while PERI values were in the range of 91.31–195.84, employing moderate ecological risks (95 < PERI < 190) from the dumpsite’s soil. Moreover, for non-carcinogenic exposure, none of the analyzed metals exceeded the threshold limit HRI values > 1 in both adults and children. Likewise, in the case of carcinogenic effects, the CRI values were lower than the tolerable limits (1 × 10−6–1 × 10−4) in both adults and children. Moreover, almost all studied plants could be utilized for the phytoextraction of mentioned HMs. In future, the present study can help in the implementation of public policies to ensure sustainability and developmental activities in contaminated sites. Based on these results, it is concluded that there is a dire need of monitoring solid waste dumpsites due to various types of potential risks associated with the contamination of HMs. Moreover, to minimize the potential health problems arising from the dumpsite, it is substantive that special attention should be paid to work on sustainable and eco-friendly remedial measures.

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“…Based on urinary Zn levels, we have two hypotheses. One is Zn deficiency ( 55 ): the absorption of Fe in the body also inhibits the absorption of Zn, and the content of Zn excreted in urine increases. In addition, the study population was over 60 years old, and the reduction of Fe accumulation and Zn absorption due to aging may be associated with HUA risk ( 56 ).…”

Section: Discussionmentioning

confidence: 99%

The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China

Huang

Gao²,

Feng³

et al. 2023

Front. Public Health

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ObjectiveIndependent and interactive effects of multiple metals levels in urine on the risk of hyperuricemia (HUA) in the elderly were investigated.MethodsA total of 6,508 individuals from the baseline population of the Shenzhen aging-related disorder cohort were included in this study. We detected urinary concentrations of 24 metals using inductively coupled plasma mass spectrometry, fitted unconditional logistic regression models, and the least absolute shrinkage and selection operator regression models for the selection of metals as well as unconditional stepwise logistic regression models and restricted cubic spline logistic regression models for assessing the associations of urinary metals and HUA risk, and finally applied generalized linear models to determine the interaction with urinary metals on the risk of HUA.ResultsUnconditional stepwise logistic regression models showed the association between urinary vanadium, iron, nickel, zinc, or arsenic and HUA risk (all P < 0.05). We revealed a negative linear dose–response relationship between urinary iron levels and HUA risk (Poverall < 0.001, Pnonliner = 0.682), a positive linear dose–response relationship between urinary zinc levels and HUA risk (Poverall < 0.001, Pnonliner = 0.513), and an additive interaction relationship between urinary low-iron and high-zinc levels and HUA risk (RERI = 0.31, 95% CI: 0.03–0.59; AP = 0.18, 95%CI: 0.02–0.34; S = 1.76, 95%CI: 1.69–3.49).ConclusionUrinary vanadium, iron, nickel, zinc, or arsenic levels were associated with HUA risk, and the additive interaction of low-iron (<78.56 μg/L) and high-zinc (≥385.39 μg/L) levels may lead to a higher risk of HUA.

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Heavy metals exposure is associated with early liver dysfunction among rural residents aged 40–75 years in southwest China

Cited by 16 publications

References 44 publications

The Molecular Mechanism of Hepatic Lipid Metabolism Disorder Caused by NaAsO2 through Regulating the ERK/PPAR Signaling Pathway

The Molecular Mechanism of Hepatic Lipid Metabolism Disorder Caused by NaAsO2 through Regulating the ERK/PPAR Signaling Pathway

Bioaccumulation of Heavy Metals in a Soil–Plant System from an Open Dumpsite and the Associated Health Risks through Multiple Routes

The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China

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