Heavy silicone oil (Densiron-68) for the treatment of persistent macular holes

Rizzo, Stanislao; Genovesi-Ebert, Federica; Vento, Andrea; Cresti, Federica; Miniaci, Sofia; Romagnoli, Maria Chiara

doi:10.1007/s00417-009-1131-5

Cited by 61 publications

(55 citation statements)

References 48 publications

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“…These encouraging anatomical results after Densiron are supported by others [9,10] . However, the use of Densiron implies the burden of another surgery to remove the silicone oil and debates about possible retinal harm due to Densiron are ongoing.…”

Section: Mh Closure Ratessupporting

confidence: 73%

“…These persistent MHs have a poor visual outcome. Strategies to treat these persistent MHs include revitrectomy with gas [6,7] , use of heavy silicone oil [8][9][10] , application of autologous platelet concentrate (APC) or serum [11][12][13][14] , and most recently ILM or lens capsule flap translocation [15,16] or surgical induction of macular detachment [17] . The usefulness of these different methods and healing adjuvants still remains controversial and studies are often small, have a rather short follow-up or lack optical coherencewith revitrectomy with gas plus APC or whole blood (WB).…”

Section: Introductionmentioning

confidence: 99%

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Persistent Full-Thickness Idiopathic Macular Hole: Anatomical and Functional Outcome of Revitrectomy with Autologous Platelet Concentrate or Autologous Whole Blood

Purtskhvanidze¹,

Frühsorger²,

Bartsch³

et al. 2017

Ophthalmologica

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Purpose: To evaluate long-term outcome after revitrectomy with autologous platelet concentrate (APC) or whole blood (WB) in persistent idiopathic macular hole (MH) after vitrectomy with internal limiting membrane (ILM) peeling. Procedures: Retrospective study of 75 eyes with persistent MH after vitrectomy with ILM peeling and gas. All patients underwent revitrectomy with gas and APC (n = 61) or WB (n = 14). Main outcome measures were anatomical closure rate and postoperative best-corrected visual acuity (BCVA). Results: Closure rate after revitrectomy was 85.2% (52/61) in the APC group and 7.1% (1/14) in the WB group. Median follow-up was 58 (range 3-147) months. Median BCVA (logMAR) in patients with finally closed MHs was 0.4 ± 0.3. Patients with defects of the ellipsoid zone had significantly worse postoperative BCVA. Morphological MH configuration (atrophic or elevated edges) did not correlate with final closure rate. Conclusions: Revitrectomy with APC and gas is a very effective treatment in persistent MH after vitrectomy with ILM peeling and gas.

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Section: Mh Closure Ratessupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Persistent Full-Thickness Idiopathic Macular Hole: Anatomical and Functional Outcome of Revitrectomy with Autologous Platelet Concentrate or Autologous Whole Blood

Purtskhvanidze¹,

Frühsorger²,

Bartsch³

et al. 2017

Ophthalmologica

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“…In such cases, as well as in cases with idiopathic MH that fail to close after PPV and ILM, very few treatment options are left. Such patients are usually submitted to extended ILM peeling [23], with or without heavy silicone oil implantation [24]. The technique presented in this study can be used in these circumstances, alone or as an adjuvant to extended ILM peeling, increasing the likelihood of successful anatomical and functional outcomes.…”

Section: Discussionmentioning

confidence: 99%

Autologous Internal Limiting Membrane Fragment Transplantation for Large, Chronic, and Refractory Macular Holes

et al. 2015

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Objective: To evaluate a technique of autologous internal limiting membrane (ILM) fragment transplantation for the treatment of large, chronic, and/or refractory macular holes (MH). Design: This was a 6-month prospective interventional case series. Method: Ten eyes of 10 patients with MH underwent pars plana vitretomy (PPV) and ILM peeling followed by transplantation of an autologous ILM fragment to the MH. Six patients had primary MH with an internal diameter greater than 500 µm and a duration of more than 18 months, including 1 patient with nonproliferative diabetic retinopathy previously treated with panretinal photocoagulation. Four eyes with MH had previously been submitted to PPV (i.e. 1 for retinal detachment and 3 to attempt to close large MH). One of the latter also displayed juxtapapillary choroidal neovascularization due to age-related macular degeneration. The primary and secondary outcomes were MH closure and improvement of the best corrected visual acuity (BCVA), respectively. Results: Complete MH closure was achieved in all cases. A statistically significant improvement in the average BCVA was observed after 6 months of follow-up (p = 0.018; paired t test). The BCVA improved in 8 eyes (80%), and in 6 of those eyes it improved by ≥15 letters. In 1 patient, the BCVA remained unchanged after the surgery, but the visual field reportedly improved. One patient experienced a slight worsening (0.16 logMAR). Two cases developed atrophy of the retinal pigment epithelium despite MH closure and BCVA improvement. Conclusion: Treatment with autologous ILM fragment transplantation seems to be an efficient alternative for large, chronic, and refractory MH.

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“…However, it causes complications, such as emulsification and inflammatory reaction. 29 Some very recent results are encouraging, 30 but most clinicians are awaiting results from ongoing heavy silicone oil trials. 12 Hydrogels and smart hydrogels seem to remain as the best candidates as long-term vitreous substitutes because they show excellent transparency and good biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

A Novel Artificial Vitreous Substitute - Foldable Capsular Vitreous Body

Gao¹

2012

Advances in Ophthalmology

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Heavy silicone oil (Densiron-68) for the treatment of persistent macular holes

Abstract: Retreatment with Densiron-68 filling was safe and achieved encouraging anatomic and functional results.

Cited by 61 publications

References 48 publications

Persistent Full-Thickness Idiopathic Macular Hole: Anatomical and Functional Outcome of Revitrectomy with Autologous Platelet Concentrate or Autologous Whole Blood

Persistent Full-Thickness Idiopathic Macular Hole: Anatomical and Functional Outcome of Revitrectomy with Autologous Platelet Concentrate or Autologous Whole Blood

Autologous Internal Limiting Membrane Fragment Transplantation for Large, Chronic, and Refractory Macular Holes

A Novel Artificial Vitreous Substitute - Foldable Capsular Vitreous Body

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